Gene: IL22

50616
IL-21|IL-22|IL-D110|IL-TIF|ILTIF|TIFIL-23|TIFa|zcyto18
interleukin 22
protein-coding
12q15
Ensembl:ENSG00000127318 MIM:605330 Vega:OTTHUMG00000169119 UniprotKB:Q9GZX6
NC_000012.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.050e-1 (AD)  3.895e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPO110.699
BPIFB30.657
OPN1MW0.652
SLC22A110.651
CALCB0.646
GSC0.642
C9orf1350.638
C10orf1260.636
CENPCP10.628
CA60.614

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF605-0.319
GPR17-0.317
TESPA1-0.311
TCHP-0.31
ABCA9-0.305
CHRM1-0.303
ZNF248-0.303
FUT9-0.3
KCNS1-0.3
SCN4B-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL22 mRNA"25614096
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased secretion of IL22 mRNA25203682
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of IL22 mRNA25203682
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine affects the reaction [IL22 protein inhibits the reaction [Bucladesine results in increased abundance of Glucose]]"26064446
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [IL22 protein results in decreased abundance of Glucose]"26064446
C1118556-formylindolo(3,2-b)carbazole"[6-formylindolo(3,2-b)carbazole binds to and results in increased activity of AHR protein] which results in increased secretion of IL22 protein"25203682
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of IL22 mRNA"25203682|2571667
D000082Acetaminophen[Acetaminophen co-treated with IL22 protein] results in increased expression of SERPINA3C mRNA23375450
D000082Acetaminophen[Acetaminophen co-treated with IL22 protein] results in increased expression of SOCS3 mRNA23375450
D000082AcetaminophenIL22 protein inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]23375450
D000082AcetaminophenIL22 protein inhibits the reaction [Acetaminophen results in increased expression of TNF protein]23375450
D000082AcetaminophenIL22 protein promotes the reaction [Acetaminophen results in increased expression of LCN2 mRNA]23375450
D000082AcetaminophenIL22 protein promotes the reaction [Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]23375450
D000111AcetylcysteineIL22 protein promotes the reaction [Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]23375450
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL22 mRNA"23499868
D039741Antigens, Dermatophagoides"oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL22 mRNA]"23499868
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL22 mRNA24449571
C525519augustic acidaugustic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of IL22 mRNA25716673
C006780bisphenol Abisphenol A results in decreased expression of IL22 mRNA25181051
D002248Carbon MonoxideCarbon Monoxide results in increased expression of IL22 mRNA21444764
D002248Carbon MonoxideHMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]21444764
D002248Carbon Monoxidetin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]21444764
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IL22 protein15122762
D002251Carbon TetrachlorideIL22 protein results in decreased susceptibility to Carbon Tetrachloride16212920
D003300CopperCopper deficiency results in increased expression of IL22 mRNA26033743
C113861corosolic acidcorosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
C113861corosolic acidcorosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
C007262deoxynivalenoldeoxynivalenol promotes the reaction [nivalenol results in increased expression of IL22 mRNA]27915442
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL22 mRNA23326479|2791544
D003994Bucladesine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine affects the reaction [IL22 protein inhibits the reaction [Bucladesine results in increased abundance of Glucose]]"26064446
D003994BucladesineIL22 protein inhibits the reaction [Bucladesine results in increased abundance of Glucose]26064446
D003994BucladesineIL22 protein inhibits the reaction [Bucladesine results in increased expression of G6PC protein]26064446
D003994BucladesineIL22 protein inhibits the reaction [Bucladesine results in increased expression of PPARGC1A protein]26064446
D003994BucladesineSTAT3 gene mutant form affects the reaction [IL22 protein inhibits the reaction [Bucladesine results in increased expression of G6PC protein]]26064446
D004041Dietary FatsIL22 protein affects the reaction [Dietary Fats affects the expression of CRTC2 mRNA]26064446
D004041Dietary FatsIL22 protein affects the reaction [Dietary Fats affects the expression of G6PC mRNA]26064446
D004137Dinitrochlorobenzene"[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL22 mRNA"23499868
D004137Dinitrochlorobenzene"oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL22 mRNA]"23499868
D005947Glucose"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine affects the reaction [IL22 protein inhibits the reaction [Bucladesine results in increased abundance of Glucose]]"26064446
D005947Glucose"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [IL22 protein results in decreased abundance of Glucose]"26064446
D005947GlucoseIL22 protein inhibits the reaction [Bucladesine results in increased abundance of Glucose]26064446
D005947GlucoseIL22 protein inhibits the reaction [Pyruvic Acid results in increased abundance of Glucose]26064446
D005947GlucoseIL22 protein inhibits the reaction [Streptozocin results in increased abundance of Glucose]26064446
D005947GlucoseIL22 protein results in decreased abundance of Glucose26064446
D005947GlucoseSTAT3 gene mutant form inhibits the reaction [IL22 protein results in decreased abundance of Glucose]26064446
C056493imiquimodimiquimod results in increased secretion of IL22 protein26149470
C056493imiquimod(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL22 protein]26149470
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL22 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL22 protein]26149470
D007840LatexLatex analog results in increased expression of IL22 mRNA24768652
D008070LipopolysaccharidesIL22 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]23375450
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of IL22 mRNA]23999131
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL22 mRNA23999131
D008070LipopolysaccharidesTetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL22 mRNA]23999131
C412811maslinic acidmaslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D009532NickelNickel results in increased expression of IL22 mRNA24768652|2558310
C038405nivalenoldeoxynivalenol promotes the reaction [nivalenol results in increased expression of IL22 mRNA]27915442
C038405nivalenolnivalenol results in increased expression of IL22 mRNA27915442
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
C052658oleanolic acid 3-acetate"oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL22 mRNA]"23499868
D052638Particulate MatterParticulate Matter results in increased expression of IL22 mRNA27341501
D010476PerfumePerfume results in increased expression of IL22 mRNA24768652
D015232DinoprostoneDinoprostone results in decreased expression of IL2219273625
D010936Plant ExtractsPlant Extracts results in increased expression of IL22 protein22491429
D019289Pyruvic AcidIL22 protein inhibits the reaction [Pyruvic Acid results in increased abundance of Glucose]26064446
D012822Silicon Dioxide[[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which co-treated with Silicon Dioxide] results in increased secretion of IL22 protein22273745
D012834SilverSilver results in increased expression of IL22 mRNA19429238
D019821SimvastatinSimvastatin results in decreased secretion of IL22 protein21856936
D012972Sodium HydroxideIL22 SNP affects the susceptibility to Sodium Hydroxide27206134
D013311StreptozocinIL22 protein inhibits the reaction [Streptozocin results in increased abundance of Glucose]26064446
D013605T-2 ToxinT-2 Toxin results in increased expression of IL22 mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of IL22 protein21525997
D013749TetrachlorodibenzodioxinLipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of IL22 mRNA]23999131
D013749Tetrachlorodibenzodioxin[[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which co-treated with Silicon Dioxide] results in increased secretion of IL22 protein22273745
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased secretion of IL22 protein22273745
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL22 mRNA]23999131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL22 mRNA16102516|2399913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL22 mRNA27913140
D013755Tetradecanoylphorbol Acetateaugustic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D013755Tetradecanoylphorbol Acetatecorosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D013755Tetradecanoylphorbol Acetatecorosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D013755Tetradecanoylphorbol Acetatemaslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D013755Tetradecanoylphorbol AcetateOleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA]26513295
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IL22 mRNA26513295
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL22 mRNA25613284
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]21444764
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL22 mRNA"26743178
D014635Valproic AcidValproic Acid results in decreased methylation of IL22 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI12513909  18599299  18675809  20462497  
GO:0045518interleukin-22 receptor binding-NAS10875937  
GO ID GO Term Qualifier Evidence PubMed
GO:0006953acute-phase response-NAS11481447  
GO:0006954inflammatory response-NAS10954742  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0051384response to glucocorticoid-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8854691Interleukin-20 family signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27769811Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis. (2016 Dec)Xue JGastroenterology
29623515DNA methylation-based subclassification of psoriasis in the Chinese Han population. (2018 Apr 5)Zhou FFront Med
23036591Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)Kazantseva MGArthritis Res Ther