Gene: PAK2

5062
PAK65|PAKgamma
p21 (RAC1) activated kinase 2
protein-coding
3q29
Ensembl:ENSG00000180370 MIM:605022 Vega:OTTHUMG00000155534 UniprotKB:Q13177
NG_009227.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.721e-1 (AD)  4.749e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCTD30.906
SH3GLB10.897
CTNNA10.895
STAG20.893
SMC30.891
ATL30.887
TCEA10.885
HPS50.883
AP3B10.881
PRPF40A0.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.59
OR4F5-0.564
ADRA1D-0.386
ABCC12-0.373
FBLN7-0.354
CHRNA2-0.348
CRH-0.336
NKX6-3-0.335
GSG1-0.329
BHLHA9-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PAK2 protein"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PAK2 protein]"21705713
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of PAK2 mRNA19643169
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PAK2 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to PAK2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PAK2 protein]26598702
C0293704-toluidine4-toluidine results in decreased expression of PAK2 mRNA27638505
D000082AcetaminophenAcetaminophen results in increased expression of PAK2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PAK2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of PAK2 mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PAK2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PAK2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of PAK2 mRNA12420312
D001151ArsenicArsenic affects the methylation of PAK2 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PAK2 protein]26598702
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAK2 mRNA"19150397|2001819
D004958EstradiolEstradiol results in decreased expression of PAK2 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PAK2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PAK2 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in decreased expression of PAK2 mRNA17720352
D002104CadmiumCadmium results in increased expression of PAK2 mRNA26187450
D002110CaffeineCaffeine results in increased activity of PAK2 protein19325779
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]"20230807
D002220CarbamazepineCarbamazepine affects the expression of PAK2 mRNA24752500
D002953Citrinin[Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein18767140
D002953CitrininCitrinin results in increased activity of PAK2 protein18767140
D002994ClofibrateClofibrate results in decreased expression of PAK2 mRNA16081524
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of PAK2 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of PAK2 mRNA19549813
D003474CurcuminCurcumin results in decreased cleavage of PAK2 protein15095415
D016572CyclosporineCyclosporine results in increased expression of PAK2 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PAK2 mRNA17361019|2126653
D002945CisplatinPAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP3 protein]21499899
D002945CisplatinPAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP6 protein]21499899
D002945CisplatinPAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP7 protein]21499899
D004008DiclofenacDiclofenac affects the expression of PAK2 mRNA24752500
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PAK2 mRNA"22485181
D004221DisulfiramDisulfiram results in decreased expression of PAK2 mRNA20530235
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PAK2 mRNA17942748
C544151jinfukangjinfukang results in decreased expression of PAK2 mRNA27392435
D008727MethotrexateMethotrexate results in increased expression of PAK2 mRNA21678067
C005219methyl cellosolvemethyl cellosolve results in increased expression of PAK2 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PAK2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PAK2 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]"20230807
D015741MetriboloneMetribolone results in decreased expression of PAK2 protein17152098
C568507N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of PAK2 protein"21888390
D009532NickelNickel results in increased expression of PAK2 mRNA24768652
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]"20230807
C030110oxaliplatinoxaliplatin results in decreased expression of PAK2 mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PAK2 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of PAK2 mRNA23999411
D052638Particulate MatterParticulate Matter results in decreased expression of PAK2 mRNA17987463
D052638Particulate MatterParticulate Matter results in increased expression of PAK2 mRNA24769257
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PAK2 mRNA23948077
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PAK2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PAK2 mRNA19162173
C059514resveratrolresveratrol results in increased expression of PAK2 protein25505154
C010327salinomycinsalinomycin results in decreased expression of PAK2 mRNA19682730
C061133tamibarotenetamibarotene affects the expression of PAK2 mRNA15498508
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PAK2 mRNA17942748
D013752TetracyclineTetracycline results in increased expression of PAK2 mRNA16917069
D013893ThiramThiram results in decreased expression of PAK2 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PAK2 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PAK2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PAK2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of PAK2 mRNA15498508
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PAK2 mRNA23537331
D014635Valproic AcidValproic Acid affects the expression of PAK2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PAK2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of PAK2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PAK2 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PAK2 gene25560391
D014810Vitamin EVitamin E results in increased expression of PAK2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS10748018  
GO:0004674protein serine/threonine kinase activity-EXP10075701  11278486  17060906  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA11121037  11805089  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI10607567  16374509  16527308  16787945  16837009  17353931  
18716323  19240112  19264842  19435845  20696164  20936779  
21516116  21555521  22705156  25416956  26496610  
GO:0005524ATP binding-IEA-  
GO:0019901protein kinase binding-IPI11121037  
GO:0030296protein tyrosine kinase activator activity-IDA11121037  
GO:0031267small GTPase binding-IPI8625410  
GO:0042802identical protein binding-IPI16837009  
GO:0045296cadherin binding-HDA25468996  
GO:0048365Rac GTPase binding-IBA21873635  
GO:0048365Rac GTPase binding-IPI8625410  
GO ID GO Term Qualifier Evidence PubMed
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0006468protein phosphorylation-IDA11805089  
GO:0006469negative regulation of protein kinase activity-TAS10748018  
GO:0006915apoptotic process-IEA-  
GO:0007165signal transduction-TAS7744004  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0016310phosphorylation-IDA21555521  
GO:0016477cell migration-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA11121037  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0031295T cell costimulation-TAS-  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0040008regulation of growth-IEA-  
GO:0043066negative regulation of apoptotic process-IMP21555521  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0046777protein autophosphorylation-IDA11805089  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA11121037  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060996dendritic spine development-IEA-  
GO:0061098positive regulation of protein tyrosine kinase activity-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:2001238positive regulation of extrinsic apoptotic signaling pathway-IMP19240112  
GO:2001271negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis-IBA21873635  
GO:2001271negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis-IDA21555521  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA25468996  
GO:0005829cytosol-IDA8625410  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164944Nef and signal transductionTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-202403TCR signalingTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-211728Regulation of PAK-2p34 activity by PS-GAP/RHG10IEA
R-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradationIEA
R-HSA-211736Stimulation of the cell death response by PAK-2p34IEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-2871796FCERI mediated MAPK activationIEA
R-HSA-373755Semaphorin interactionsTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389359CD28 dependent Vav1 pathwayTAS
R-HSA-3928664Ephrin signalingTAS
R-HSA-397014Muscle contractionTAS
R-HSA-399954Sema3A PAK dependent Axon repulsionTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-428540Activation of RAC1IEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5218920VEGFR2 mediated vascular permeabilityTAS
R-HSA-5357801Programmed Cell DeathIEA
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5621575CD209 (DC-SIGN) signalingTAS
R-HSA-5627123RHO GTPases activate PAKsTAS
R-HSA-5627123RHO GTPases activate PAKsIEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-75153Apoptotic execution phaseIEA
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29092026COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression. (2018 Jan 15)Nedeljkovic IHum Mol Genet