Gene: GEMIN4

50628
HC56|HCAP1|HHRF-1|NEDMCR|p97
gem nuclear organelle associated protein 4
protein-coding
17p13.3
Ensembl:ENSG00000179409 MIM:606969 Vega:OTTHUMG00000177495 UniprotKB:P57678
NG_046938.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.791e-1 (AD)  7.863e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH10.902
DHX330.901
GBF10.898
KPNA60.895
KAT70.895
COG10.894
ATG70.893
TMEM1310.891
MTOR0.891
SUGP20.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.47
OR4F29-0.412
SH2D1A-0.396
HEY2-0.366
CTNNA3-0.365
KLRC2-0.356
COPZ2-0.345
CSAG1-0.344
RAI14-0.344
MTRNR2L9-0.337

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of GEMIN4 mRNA"19561079
D020106AcrylamideAcrylamide results in increased expression of GEMIN4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GEMIN4 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GEMIN4 mRNA19770486
D000393Air PollutantsGEMIN4 gene SNP affects the susceptibility to Air Pollutants26724585
D000393Air PollutantsGEMIN4 SNP affects the reaction [Air Pollutants affects the expression of ICAM1 protein]21600003
D000393Air PollutantsGEMIN4 SNP affects the reaction [Air Pollutants affects the expression of VCAM1 protein]21600003
D001280AtrazineAtrazine results in decreased expression of GEMIN4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GEMIN4 mRNA19770486
D004958EstradiolEstradiol affects the expression of GEMIN4 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of GEMIN4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GEMIN4 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of GEMIN4 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of GEMIN4 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of GEMIN4 mRNA24247028
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of GEMIN4 mRNA20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of GEMIN4 mRNA20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GEMIN4 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of GEMIN4 mRNA]20847119
C100187chloropicrinchloropicrin results in decreased expression of GEMIN4 mRNA26352163
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of GEMIN4 mRNA21356183
C018021cobaltous chloridecobaltous chloride results in decreased expression of GEMIN4 mRNA19320972|1937684
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of GEMIN4 mRNA21356183
D003300CopperCopper results in decreased expression of GEMIN4 mRNA21356183
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of GEMIN4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of GEMIN4 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of GEMIN4 mRNA19167446
D003703DemecolcineDemecolcine results in decreased expression of GEMIN4 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GEMIN4 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GEMIN4 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of GEMIN4 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of GEMIN4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of GEMIN4 mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GEMIN4 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GEMIN4 mRNA23649840
D005485FlutamideFlutamide results in increased expression of GEMIN4 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of GEMIN4 mRNA20655997|2364984
C492448ICG 001ICG 001 results in increased expression of GEMIN4 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of GEMIN4 mRNA28201806
C045463leflunomideleflunomide results in decreased expression of GEMIN4 mRNA28988120
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GEMIN4 mRNA16507785
D008727MethotrexateMethotrexate affects the expression of GEMIN4 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GEMIN4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GEMIN4 mRNA23649840
C022838nickel chloridenickel chloride results in decreased expression of GEMIN4 mRNA17312168
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of GEMIN4 mRNA20971185
D052638Particulate MatterGEMIN4 SNP affects the reaction [Particulate Matter affects the expression of ICAM1 protein]21600003
D052638Particulate MatterGEMIN4 SNP affects the reaction [Particulate Matter affects the expression of VCAM1 protein]21600003
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of GEMIN4 mRNA20847119
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of GEMIN4 mRNA20847119
D012834SilverSilver results in decreased expression of GEMIN4 mRNA26014281
D012969Sodium FluorideSodium Fluoride results in increased expression of GEMIN4 protein28918527
D012999SomanSoman results in decreased expression of GEMIN4 mRNA19281266
D053260SootGEMIN4 gene SNP affects the susceptibility to Soot20211803|2672458
D013431SulfatesGEMIN4 SNP affects the reaction [Sulfates affects the expression of ICAM1 protein]21600003
D013431SulfatesGEMIN4 SNP affects the reaction [Sulfates affects the expression of VCAM1 protein]21600003
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of GEMIN4 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of GEMIN4 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GEMIN4 mRNA21570461
D019284ThapsigarginThapsigargin results in decreased expression of GEMIN4 mRNA24247028
D013849ThimerosalThimerosal results in decreased expression of GEMIN4 mRNA16870260
C012589trichostatin Atrichostatin A affects the expression of GEMIN4 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GEMIN4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GEMIN4 mRNA"26179874
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of GEMIN4 mRNA]20847119
D014520UrethaneUrethane results in decreased expression of GEMIN4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GEMIN4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GEMIN4 mRNA22083351|2915479
D014635Valproic AcidValproic Acid results in increased methylation of GEMIN4 gene29154799
D001335Vehicle EmissionsGEMIN4 gene SNP affects the susceptibility to Vehicle Emissions26724585
C025643vinclozolinvinclozolin results in increased expression of GEMIN4 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10725331  11714716  12869526  17353931  19750007  21988832  
23752268  
GO ID GO Term Qualifier Evidence PubMed
GO:0000387spliceosomal snRNP assembly-IBA21873635  
GO:0000387spliceosomal snRNP assembly-IDA18984161  
GO:0000387spliceosomal snRNP assembly-TAS-  
GO:0006364rRNA processing-IEA-  
GO:0051170import into nucleus-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-TAS10725331  
GO:0005829cytosol-IDA18984161  20513430  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016604nuclear body-IDA-  
GO:0030532small nuclear ribonucleoprotein complex-TAS10725331  
GO:0032797SMN complex-IBA21873635  
GO:0032797SMN complex-IDA18984161  
GO:0034719SMN-Sm protein complex-IBA21873635  
GO:0034719SMN-Sm protein complex-IDA18984161  
GO:0070062extracellular exosome-HDA19056867  
GO:0097504Gemini of coiled bodies-IEA-  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-191859snRNP AssemblyTAS
R-HSA-194441Metabolism of non-coding RNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25495208Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. (2015 Mar)Gedik HDNA Cell Biol