Gene: CALY

50632
DRD1IP|NSG3
calcyon neuron specific vesicular protein
protein-coding
10q26.3
Ensembl:ENSG00000130643 MIM:604647 Vega:OTTHUMG00000019310 UniprotKB:Q9NYX4
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.019e-1 (AD)  3.851e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BSCL20.941
CDK50.941
TMEM59L0.939
MAPRE30.938
SLC22A170.937
PGP0.935
DUSP260.933
P4HTM0.933
PIANP0.931
SPINT20.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.534
REST-0.501
RAI14-0.499
KCNJ15-0.488
TFPI2-0.485
FZD10-0.482
TFPI-0.469
CNN2-0.467
FOLR3-0.466

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00714ApomorphineSmall Molecule58-00-4Approved|InvestigationalTarget
DB00831TrifluoperazineSmall Molecule117-89-5Approved|InvestigationalTarget
DB05419ADX-10061Small Molecule-InvestigationalTarget
DB05432DAS-431 IVSmall Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CALY mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CALY mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CALY mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CALY mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CALY mRNA"25510870
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CALY mRNA16483693
D004958EstradiolEstradiol results in decreased expression of CALY mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of CALY mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CALY gene20938992
D003042CocaineCocaine results in increased expression of CALY mRNA20171207
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CALY mRNA27392435
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CALY mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CALY gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of CALY mRNA19167457
D005947GlucoseCALY protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]21124846
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CALY mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of CALY mRNA16807920
D007854LeadLead affects the expression of CALY mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CALY gene20938992
C028007nickel monoxidenickel monoxide results in decreased expression of CALY mRNA19167457
D010100OxygenCALY protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]21124846
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CALY mRNA"25510870
D011374ProgesteroneProgesterone results in decreased expression of CALY mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of CALY mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CALY mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CALY mRNA17942748
D014635Valproic AcidValproic Acid affects the expression of CALY mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CALY mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of CALY gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16595675  
GO:0032051clathrin light chain binding-IBA21873635  
GO:0032051clathrin light chain binding-IDA16595675  
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-IEA-  
GO:0007212dopamine receptor signaling pathway-IEA-  
GO:0016197endosomal transport-IBA21873635  
GO:0045807positive regulation of endocytosis-IMP16595675  
GO:0048268clathrin coat assembly-IBA21873635  
GO:0048268clathrin coat assembly-IDA16595675  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IBA21873635  
GO:0005887integral component of plasma membrane-IDA14534309  
GO:0016021integral component of membrane-IBA21873635  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0031410cytoplasmic vesicle-IDA14534309  16595675  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21415033Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. (2011 May 1)Li DAm J Epidemiol