Gene: PALM

5064
-
paralemmin
protein-coding
19p13.3
Ensembl:ENSG00000099864 MIM:608134 Vega:OTTHUMG00000181785 UniprotKB:O75781
NC_000019.10
PubMed
0   ANCO-SNPs
OD|ND|AD
5   
5.822e-1 (AD)  1.330e-1 (ND)   (Frontal_Cortex)
7.735e-1 (AD)  1.778e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19925025chr19:710823PALMGene body3.993e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBD30.946
BTBD20.939
NSMF0.935
ST6GALNAC60.932
DVL10.929
GIT10.924
ZNF3580.922
PPP1R16A0.911
NELFB0.906
PDZD40.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.831
OR4F29-0.797
CNTF-0.232
ANXA13-0.228
C9orf135-0.224
AGTR1-0.22
PROKR1-0.22
DTHD1-0.22
TFPI2-0.216
VRK2-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PALM mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PALM mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of PALM mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PALM mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PALM mRNA16483693
D001151ArsenicArsenic results in increased methylation of PALM promoter21291286
D001280AtrazineAtrazine results in decreased expression of PALM mRNA25929836
D004958EstradiolEstradiol results in increased expression of PALM mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PALM mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PALM promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of PALM mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of PALM protein28903499
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PALM mRNA20938992
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PALM mRNA17361019
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PALM promoter23359474
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PALM mRNA27392435
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PALM promoter23359474
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PALM mRNA20938992
D019833GenisteinGenistein results in increased expression of PALM mRNA23019147
C016517indole-3-carbinolindole-3-carbinol affects the expression of PALM mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PALM mRNA27392435
C544151jinfukangjinfukang results in increased expression of PALM mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PALM mRNA25982114
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PALM mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PALM mRNA"20188158
D009532NickelNickel results in decreased expression of PALM mRNA25583101
D010100OxygenOxygen deficiency results in increased expression of PALM mRNA26516004
D012906SmokeSmoke results in decreased expression of PALM mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PALM mRNA21570461
C024746tobacco tartobacco tar results in decreased expression of PALM mRNA19559774
D014635Valproic AcidValproic Acid results in increased methylation of PALM gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PALM gene25560391
D019287Zinc SulfateZinc Sulfate results in decreased expression of PALM mRNA27215404
C088658zoledronic acidzoledronic acid results in decreased expression of PALM mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16386234  
GO:0031750D3 dopamine receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007194negative regulation of adenylate cyclase activity-IBA21873635  
GO:0007194negative regulation of adenylate cyclase activity-IDA16386234  
GO:0008360regulation of cell shape-IEA-  
GO:0023052signaling-IBA21873635  
GO:0051491positive regulation of filopodium assembly-IBA21873635  
GO:0051491positive regulation of filopodium assembly-IDA14978216  
GO:0060074synapse maturation-IEA-  
GO:0060160negative regulation of dopamine receptor signaling pathway-IDA16386234  
GO:0071257cellular response to electrical stimulus-IEA-  
GO:0072659protein localization to plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA16386234  
GO:0014069postsynaptic density-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016327apicolateral plasma membrane-IEA-  
GO:0030424axon-IEA-  
GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane-TAS9813098  
GO:0031410cytoplasmic vesicle-TAS9813098  
GO:0031527filopodium membrane-IDA14978216  
GO:0032591dendritic spine membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23286246Perturbation of cellular immune functions in cigarette smokers and protection by palm oil vitamin E supplementation. (2013 Jan 3)Jubri ZNutr J
29808515Dynamic lateral organization of opioid receptors (kappa, muwt and muN40D ) in the plasma membrane at the nanoscale level. (2018 May 28)Rogacki MKTraffic
10528821Patterns of alcohol consumption in the Seychelles Islands (Indian Ocean). (1999 Sep-Oct)Perdrix JAlcohol Alcohol
18028530Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment. (2008 Jan)Tidey JWAlcohol Clin Exp Res
28339973Day-to-Day Variability in Self-Reported Cigarettes Per Day. (2017 Sep 1)Hughes JRNicotine Tob Res