Gene: ARHGEF3

50650
GEF3|STA3|XPLN
Rho guanine nucleotide exchange factor 3
protein-coding
3p14.3
Ensembl:ENSG00000163947 MIM:612115 Vega:OTTHUMG00000158857 UniprotKB:Q9NR81
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.356e-1 (AD)  4.505e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11916112chr3:56890683 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18482892chr3:56833426ARHGEF31.500e-10Smoking27651444
cg18482892chr3:56833426ARHGEF31.150e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO340.964
PRPS20.959
MAP2K40.952
BTBD100.95
SYNJ10.949
AMPH0.949
NELL20.948
TMEM2460.948
CNST0.947
BHLHB90.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.518
MYL3-0.478
ASB4-0.477
MYOM1-0.476
COPZ2-0.471
YES1-0.462
CSAG1-0.461
MBNL3-0.459
RAI14-0.452
CHST14-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ARHGEF3 mRNA"21354444
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARHGEF3 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ARHGEF3 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ARHGEF3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ARHGEF3 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ARHGEF3 mRNA"15215175
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of ARHGEF3 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ARHGEF3 mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ARHGEF3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ARHGEF3 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ARHGEF3 protein20106945
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ARHGEF3 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ARHGEF3 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of ARHGEF3 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ARHGEF3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARHGEF3 mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of ARHGEF3 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of ARHGEF3 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ARHGEF3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ARHGEF3 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of ARHGEF3 mRNA24752500
D007631ChlordeconeARHGEF3 gene SNP affects the susceptibility to Chlordecone25622337
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ARHGEF3 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ARHGEF3 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ARHGEF3 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ARHGEF3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ARHGEF3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ARHGEF3 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of ARHGEF3 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of ARHGEF3 mRNA21198554
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ARHGEF3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of ARHGEF3 mRNA23625948
D004008DiclofenacDiclofenac affects the expression of ARHGEF3 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ARHGEF3 mRNA26924002
D002117CalcitriolCalcitriol results in decreased expression of ARHGEF3 mRNA16002434
C118739entinostatentinostat results in increased expression of ARHGEF3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGEF3 mRNA22079256
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNA16996129
D005557FormaldehydeFormaldehyde results in decreased expression of ARHGEF3 mRNA20655997
D005839GentamicinsGentamicins results in increased expression of ARHGEF3 mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGEF3 mRNA25613284
D007854LeadLead affects the expression of ARHGEF3 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ARHGEF3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARHGEF3 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of ARHGEF3 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARHGEF3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARHGEF3 mRNA"25554681
D009532NickelNickel results in decreased expression of ARHGEF3 mRNA23195993
D010634PhenobarbitalPhenobarbital affects the expression of ARHGEF3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ARHGEF3 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of ARHGEF3 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of ARHGEF3 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGEF3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARHGEF3 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ARHGEF3 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of ARHGEF3 mRNA18070364
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARHGEF3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ARHGEF3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ARHGEF3 mRNA19073995
D012834SilverSilver results in decreased expression of ARHGEF3 mRNA26014281
C017947sodium arsenitesodium arsenite affects the methylation of ARHGEF3 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGEF3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARHGEF3 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGEF3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGEF3 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ARHGEF3 mRNA23411599
D014212TretinoinTretinoin results in increased expression of ARHGEF3 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of ARHGEF3 mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ARHGEF3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ARHGEF3 mRNA23179753|2352703
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARHGEF3 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF3 mRNA"27188386
D019287Zinc SulfateZinc Sulfate results in decreased expression of ARHGEF3 mRNA12756304
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNA16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007266Rho protein signal transduction-TAS10873612  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal