Gene info: ID 5069

Gene: PAPPA

GENE ID: 5069

Description: pappalysin 1

Gene type: protein-coding

Location: 9q33.1

dbXrefs: Ensembl:ENSG00000182752 MIM:176385 Vega:OTTHUMG00000021045 UniprotKB:Q13219

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.778e-2 (AD) 9.120e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNC	0.575
GPR87	0.539
ESR2	0.527
SERPINB8	0.51
FRMD3	0.509
ZNF800	0.507
ZNF587B	0.504
GBE1	0.5
FBN2	0.499
SPOCD1	0.492

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C16orf74	-0.29
RXRG	-0.268
TMEM253	-0.267
TMSB4Y	-0.262
RPS4Y1	-0.258
BTBD17	-0.255
DBP	-0.254
EIF1AY	-0.245
NXNL1	-0.243
FAM69C	-0.237

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C018535	2-ethylhexyldiphenylphosphate	2-ethylhexyldiphenylphosphate results in decreased expression of PAPPA mRNA	28282128
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of PAPPA mRNA"	24172598
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]	24781252
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA]	24781252
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PAPPA gene	27153756
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of PAPPA mRNA	28522335
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of PAPPA mRNA	21298039
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of PAPPA mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PAPPA mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PAPPA mRNA	22521957
C015001	arsenite	arsenite results in increased methylation of PAPPA promoter	23974009
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of PAPPA mRNA"	24160326
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of PAPPA mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PAPPA mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of PAPPA gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PAPPA mRNA	23735875
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PAPPA mRNA"	20382639
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAPPA mRNA"	19150397\|2001819
D004958	Estradiol	PAPPA protein affects the reaction [CGB3 protein results in increased abundance of Estradiol]	20130263
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of PAPPA mRNA	20404318
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of PAPPA mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of PAPPA mRNA	19429434
D004958	Estradiol	Estradiol results in increased expression of PAPPA mRNA	19484750
C006780	bisphenol A	bisphenol A results in increased expression of PAPPA mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of PAPPA mRNA	24066056\|2518105
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PAPPA mRNA	20147733
C018475	butyraldehyde	butyraldehyde results in decreased expression of PAPPA mRNA	26079696
D003513	Cycloheximide	Cycloheximide results in increased expression of PAPPA mRNA	19684285
D003513	Cycloheximide	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PAPPA mRNA	19684285
D003609	Dactinomycin	Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]	16338976
D003609	Dactinomycin	Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA]	16338976
D003907	Dexamethasone	Dexamethasone results in decreased expression of PAPPA mRNA	25047013
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PAPPA mRNA	17361019\|2126653
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of PAPPA mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of PAPPA mRNA	19561079\|2739243
D002117	Calcitriol	Calcitriol results in increased expression of PAPPA mRNA	26485663
D004237	Diuron	Diuron metabolite results in increased expression of PAPPA mRNA	24172598
C118739	entinostat	entinostat results in increased expression of PAPPA mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
D005557	Formaldehyde	Formaldehyde results in decreased expression of PAPPA mRNA	17938736
C069837	fullerene C60	fullerene C60 results in decreased expression of PAPPA mRNA	19167457
C001277	geldanamycin	geldanamycin results in increased expression of PAPPA mRNA	26705709
C056507	gemcitabine	gemcitabine results in decreased expression of PAPPA protein	20531411
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of PAPPA mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PAPPA mRNA	24796395
D007840	Latex	Latex analog results in decreased expression of PAPPA mRNA	24768652
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PAPPA mRNA	26378955
D008345	Manganese	Manganese results in increased expression of PAPPA mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of PAPPA mRNA	17175027
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
D008731	Methoxychlor	Methoxychlor results in increased methylation of PAPPA gene	19589859
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PAPPA mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PAPPA mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PAPPA mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of PAPPA mRNA	18978301
C502362	N-butyrylglucosamine	N-butyrylglucosamine results in increased expression of PAPPA mRNA	16142878
D016912	Levonorgestrel	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PAPPA mRNA	19074003
D010100	Oxygen	Oxygen deficiency results in increased expression of PAPPA mRNA	26516004
C568608	PCI 5002	PCI 5002 results in decreased expression of PAPPA mRNA	18593933
C058305	phenethyl isothiocyanate	PAPPA protein binds to phenethyl isothiocyanate	21838287
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAPPA mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PAPPA mRNA	26272509
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of PAPPA mRNA	21334430
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of PAPPA mRNA	23608068
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of PAPPA mRNA	20660070
D011374	Progesterone	PAPPA protein affects the reaction [CGB3 protein results in increased abundance of Progesterone]	20130263
D011374	Progesterone	Progesterone results in decreased expression of PAPPA mRNA	21273126
D011374	Progesterone	Progesterone results in increased expression of PAPPA mRNA	18497975\|2179573
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PAPPA mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of PAPPA mRNA	27029645
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]	24781252
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of PAPPA mRNA	19429434
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased activity of PAPPA protein]	24781252
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]	16338976\|2478125
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of PAPPA protein]	16338976
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA]	16338976\|2478125
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of PAPPA protein]	16338976
C059514	resveratrol	resveratrol results in decreased expression of PAPPA mRNA	24781252
C059514	resveratrol	resveratrol results in decreased expression of PAPPA protein	24781252
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of PAPPA mRNA"	24160326
C009277	sodium arsenate	sodium arsenate results in decreased expression of PAPPA mRNA	21795629
D018038	Sodium Selenite	Sodium Selenite results in increased expression of PAPPA mRNA	24383545
D013256	Steroids	PAPPA protein affects the chemical synthesis of Steroids	20130263
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PAPPA mRNA	26378955
C010792	testosterone undecanoate	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PAPPA mRNA	19074003
C010792	testosterone undecanoate	testosterone undecanoate results in decreased expression of PAPPA mRNA	19074003
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PAPPA mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PAPPA mRNA	19684285\|2615948
C009495	titanium dioxide	titanium dioxide results in increased expression of PAPPA mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PAPPA mRNA	28111298
D014212	Tretinoin	Tretinoin results in decreased expression of PAPPA mRNA	21934132
C032910	triadimefon	triadimefon results in decreased expression of PAPPA mRNA	26705709
C012589	trichostatin A	trichostatin A results in increased expression of PAPPA mRNA	24935251\|2670570
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of PAPPA mRNA	28282128
C057693	troglitazone	troglitazone results in increased expression of PAPPA mRNA	19140230
D017974	Uranium Compounds	Uranium Compounds results in increased expression of PAPPA mRNA	19654044
D014635	Valproic Acid	Valproic Acid results in decreased expression of PAPPA mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased expression of PAPPA mRNA	23179753\|2493525
D014638	Vanadates	Vanadates results in increased expression of PAPPA mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of PAPPA gene	25560391
C088658	zoledronic acid	zoledronic acid results in decreased expression of PAPPA mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004222	metalloendopeptidase activity	-	EXP	11513734
GO:0004222	metalloendopeptidase activity	-	TAS	-
GO:0008237	metallopeptidase activity	-	IDA	10077652
GO:0008237	metallopeptidase activity	-	NAS	10913121
GO:0008270	zinc ion binding	-	NAS	10077652 10913121

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IEA	-
GO:0007565	female pregnancy	-	NAS	10077652 10913121
GO:0032354	response to follicle-stimulating hormone	-	IEA	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0051384	response to glucocorticoid	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	10077652
GO:0005576	extracellular region	-	NAS	10913121
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18946222	Comparison of the new PRC software with the established algorithm of the FMF UK for the detection of trisomy 21 and 18/13. (2008)	Luthgens K	Fetal Diagn Ther
26106266	Combination of PAPPA, fhCGbeta, AFP, PlGF, sTNFR1, and Maternal Characteristics in Prediction of Early-onset Preeclampsia. (2015)	Yliniemi A	Clin Med Insights Reprod Health