Gene: PAX1

5075
HUP48|OFC2
paired box 1
protein-coding
20p11.22
Ensembl:ENSG00000125813 MIM:167411 Vega:OTTHUMG00000032034 UniprotKB:P15863
NG_047065.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.742e-3 (AD)  7.574e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELSPBP10.349
IRX30.348
OXT0.333
HMX10.318
DAPL10.317
CEACAM70.317
NKX2-40.314
LHX50.314
C5orf380.314
C15orf320.313

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROG3-0.246
PTCRA-0.226
DQX1-0.224
CPO-0.218
MYBPHL-0.216
ALDOB-0.215
TDRD6-0.208
NUF2-0.206
CGB7-0.203
BRCA1-0.203

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PAX1 mRNA22230336
D000447AldehydesAldehydes results in increased expression of PAX1 mRNA25014914
D001151ArsenicArsenic affects the methylation of PAX1 gene25304211
C015001arsenitearsenite results in increased methylation of PAX1 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of PAX1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PAX1 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of PAX1 mRNA26079696
D003300CopperCopper deficiency results in increased expression of PAX1 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of PAX1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PAX1 mRNA21592394
D004726EndosulfanEndosulfan results in decreased expression of PAX1 mRNA26615145
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PAX1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAX1 mRNA17942748
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PAX1 mRNA"20188158
D009532NickelNickel results in increased expression of PAX1 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PAX1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PAX1 mRNA27935865
C046012pentanalpentanal results in increased expression of PAX1 mRNA26079696
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PAX1 mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in increased expression of PAX1 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of PAX1 mRNA26079696
C017947sodium arsenitesodium arsenite affects the methylation of PAX1 gene28589171
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PAX1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PAX1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PAX1 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAX1 mRNA17942748
D014212TretinoinTretinoin affects the expression of PAX1 mRNA8674422
D014212TretinoinTretinoin results in increased expression of PAX1 mRNA15576409
D014212TretinoinTretinoin affects the expression of PAX1 mRNA9894676
D014635Valproic AcidValproic Acid results in decreased expression of PAX1 mRNA8948545
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PAX1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PAX1 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PAX1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0005515protein binding-IPI11423130  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS9671740  
GO:0001756somitogenesis-IEA-  
GO:0006366transcription by RNA polymerase II-TAS1358810  
GO:0008283cell proliferation-IEA-  
GO:0043367CD4-positive, alpha-beta T cell differentiation-IEA-  
GO:0043374CD8-positive, alpha-beta T cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048538thymus development-IEA-  
GO:0060017parathyroid gland development-IEA-  
GO:0060349bone morphogenesis-IEA-  
GO:0061056sclerotome development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23907469DNA methylation of PAX1 as a biomarker for oral squamous cell carcinoma. (2014 Apr)Huang YKClin Oral Investig
27865370Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. (2016 Nov)Cheng SJOral Oncol
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics