Gene: PAX5

5079
ALL3|BSAP
paired box 5
protein-coding
9p13.2
Ensembl:ENSG00000196092 MIM:167414 Vega:OTTHUMG00000019907 UniprotKB:Q02548
NG_033894.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.104e-1 (AD)  4.706e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3824339chr9:36885749 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13959831chr9:36938341PAX54.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAB10.458
PRKG20.448
DACT10.446
CHRNA60.445
ALK0.439
UBD0.438
AFAP10.437
KCNK130.436
DOK60.436
NPR30.435

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD23-0.335
SH2D6-0.294
NRN1L-0.283
IP6K3-0.28
MCM7-0.28
GPIHBP1-0.279
CD22-0.277
SFTPC-0.264
RHBDL2-0.263
BOK-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PAX5 mRNA"23962555
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX5 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PAX5 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of PAX5 mRNA20458559
C015001arsenitearsenite results in increased methylation of PAX5 promoter23974009
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of PAX5 mRNA17404688
C006780bisphenol Abisphenol A affects the expression of PAX5 mRNA23557687
C006780bisphenol Abisphenol A affects the methylation of PAX5 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of PAX5 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PAX5 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PAX5 promoter22457795
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PAX5 mRNA28962523
C118739entinostatentinostat results in increased expression of PAX5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX5 mRNA"27188386
C070081fulvestrantfulvestrant results in increased expression of PAX5 mRNA12154049
C401858GW 7604GW 7604 results in increased expression of PAX5 mRNA12154049
D000068877Imatinib MesylateCDK6 protein inhibits the reaction [Imatinib Mesylate results in increased expression of PAX5 mRNA]21536647
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of PAX5 mRNA21536647
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PAX5 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of PAX5 mRNA18927307
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to PAX5 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PAX5 mRNA24332044
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PAX5 protein24332044
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of PAX5 mRNA25656449
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of PAX5 protein]25656449
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of PAX5 protein]25656449
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of PAX5 protein25656449
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of and results in decreased activity of PAX5 protein14600275
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PAX5 mRNA14600275|1848319
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PAX5 mRNA alternative form18483191
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PAX5 protein18483191
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of PAX5 protein]14600275
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 mRNA]14600275|1848319
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 mRNA alternative form]18483191
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 protein]18483191
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA23017109
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of PAX5 mRNA26518055
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA23017109
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of PAX5 mRNA17404688
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of PAX5 mRNA12154049
D053260SootSoot results in decreased expression of PAX5 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PAX5 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with CD40LG protein] results in increased expression of PAX5 mRNA21807014
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with CD40LG protein] results in increased expression of PAX5 protein21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of PAX5 protein]14600275
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 mRNA]14600275|1848319
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 mRNA alternative form]18483191
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 protein]18483191
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [PRDM1 protein binds to PAX5 promoter]19237549
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PAX5 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of PAX5 promoter25214829
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PAX5 mRNA20133372
D014212TretinoinTretinoin results in increased expression of PAX5 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of PAX5 mRNA16093312
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PAX5 mRNA19042947
D014635Valproic AcidValproic Acid results in increased expression of PAX5 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0005515protein binding-IPI24735925  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-TAS10524622  
GO:0006959humoral immune response-TAS10524629  
GO:0007275multicellular organism development-TAS10524629  
GO:0007283spermatogenesis-IEA-  
GO:0007568aging-IEA-  
GO:0009887animal organ morphogenesis-TAS10524622  
GO:0021670lateral ventricle development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0030534adult behavior-IEA-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO:0050855regulation of B cell receptor signaling pathway-TAS-  
GO:0051573negative regulation of histone H3-K9 methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939245RUNX1 regulates transcription of genes involved in BCR signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29263590Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke. (2017 Nov)Pinello KCVet World
22199344Clinical significance of hypermethylation status in NSCLC: evaluation of a 30-gene panel in patients with advanced disease. (2011 Dec)Pesek MAnticancer Res
25214829Effect of cigarette smoke condensate on gene promoter methylation in human lung cells. (2014)Lyn-Cook LTob Induc Dis
21298317Impact of smoking on inflammation: overview of molecular mechanisms. (2011 May)Goncalves RBInflamm Res