Gene: PAX6

5080
AN|AN2|ASGD5|D11S812E|FVH1|MGDA|WAGR
paired box 6
protein-coding
11p13
Ensembl:ENSG00000007372 MIM:607108 Vega:OTTHUMG00000041447 UniprotKB:P26367
NG_008679.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.489e-1 (AD)  5.136e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21764190chr11:31835534PAX6Promoter5.929e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP20.928
ARHGEF260.926
BMPR1B0.923
STOX10.922
SOX90.921
SLC1A30.905
RFX20.901
CHDH0.899
CLDN100.897
GJA10.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP27-0.479
CACNA1F-0.459
TRABD2A-0.455
SLIT3-0.451
SAMD5-0.447
QRFPR-0.446
AGMAT-0.435
ADTRP-0.434
OSBPL10-0.431
COL19A1-0.431

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PAX6 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PAX6 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PAX6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
D000079AcetaldehydeAcetaldehyde results in decreased expression of PAX6 mRNA22634333
D019342Acetic AcidAcetic Acid affects the expression of PAX6 protein21296659
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PAX6 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PAX6 mRNA16483693
D001151ArsenicArsenic results in decreased expression of PAX6 mRNA24019935
C015001arsenitearsenite results in increased methylation of PAX6 promoter23974009
D001554BenzeneBenzene results in decreased expression of PAX6 mRNA15120971|1512265
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PAX6 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of PAX6 mRNA25051057
C006780bisphenol Abisphenol A results in increased expression of PAX6 mRNA17785945
C006780bisphenol Abisphenol A affects the methylation of PAX6 promoter27334623
C006780bisphenol Abisphenol A affects the expression of PAX6 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of PAX6 mRNA25963729
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA]25963729
C006780bisphenol Abisphenol A results in decreased expression of PAX6 mRNA17268083
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of PAX6 protein21296659
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PAX6 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of PAX6 mRNA26079696
D002104CadmiumCadmium results in increased expression of PAX6 mRNA24482418
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PAX6 mRNA23741332
D002118CalciumCalcium affects the expression of PAX6 mRNA15913539
D002220CarbamazepineCarbamazepine results in decreased expression of PAX6 mRNA22634333
D002235CarbofuranCarbofuran results in decreased expression of PAX6 mRNA28982980
C473710Chir 98014Chir 98014 results in decreased expression of PAX6 mRNA22723015
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PAX6 mRNA16934159
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PAX6 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PAX6 gene20938992
D003471CuprizoneCuprizone results in increased expression of PAX6 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA]25963729
D003474CurcuminCurcumin results in increased expression of PAX6 mRNA25963729
D016572CyclosporineCyclosporine results in increased expression of PAX6 mRNA20106945|2556210
C093628cyproconazolecyproconazole results in increased expression of PAX6 mRNA22045034
D003561CytarabineCytarabine results in decreased expression of PAX6 protein21198554
D003561CytarabineCytarabine results in increased expression of PAX6 mRNA21198554
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PAX6 mRNA23640034
C014347decitabinedecitabine results in increased expression of PAX6 mRNA16367923
D003976DiazinonDiazinon results in decreased methylation of PAX6 gene22964155
D004008DiclofenacDiclofenac results in increased expression of PAX6 mRNA26934552
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PAX6 protein25280772
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PAX6 mRNA"27840820
D004317DoxorubicinDoxorubicin results in increased expression of PAX6 mRNA16404146
C118739entinostatentinostat results in decreased expression of PAX6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]26420483
D005013EthosuximideEthosuximide results in increased expression of PAX6 mRNA26420483
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PAX6 exon16303964
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PAX6 gene16724327
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PAX6 intron16303964
D005472FluorouracilFluorouracil results in increased expression of PAX6 protein21296659
C061365flusilazoleflusilazole results in increased expression of PAX6 mRNA22634333
D005492Folic AcidFolic Acid results in increased expression of PAX6 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PAX6 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of PAX6 mRNA19167457
D005947GlucoseGlucose results in decreased expression of PAX6 mRNA21818840
D006582HexachloropheneHexachlorophene results in decreased expression of PAX6 mRNA25943520
D006582HexachloropheneHexachlorophene results in decreased expression of PAX6 protein25943520
C538724HhAntag691HhAntag691 results in increased expression of PAX6 mRNA27585885
D017313FenretinideFenretinide results in decreased expression of PAX6 protein17110918
C082359imidaclopridimidacloprid results in decreased expression of PAX6 mRNA27444676
C515747isosteviolisosteviol results in increased expression of PAX6 mRNA22479612
D007854LeadLead results in decreased expression of PAX6 mRNA24519525
C008261lead acetatelead acetate results in increased expression of PAX6 mRNA22609695
D008344Maneb[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA23017109
C042720mercuric bromidemercuric bromide results in decreased expression of PAX6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PAX6 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PAX6 mRNA22555245|2800136
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PAX6 mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PAX6 mRNA22555245
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PAX6 mRNA"20188158
D010100OxygenOxygen deficiency results in decreased expression of PAX6 mRNA24236059
D019308Palmitic AcidPalmitic Acid results in increased expression of PAX6 mRNA22479612
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of PAX6 mRNA26272509
D010269Paraquat[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA23017109
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased activity of PAX6 protein27589886
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PAX6 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PAX6 mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of PAX6 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of PAX6 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PAX6 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PAX6 mRNA19073995
D012834SilverSilver results in decreased expression of PAX6 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of PAX6 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of PAX6 mRNA28595984
D013605T-2 ToxinT-2 Toxin results in increased expression of PAX6 mRNA26314264
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PAX6 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PAX6 mRNA19465110
D014212TretinoinTretinoin results in decreased expression of PAX6 mRNA21934132
D014212TretinoinTretinoin results in increased expression of PAX6 mRNA16604517
D014212TretinoinTretinoin results in increased expression of PAX6 protein15996115
D014212Tretinoin[Tretinoin co-treated with SIX3 protein] results in increased expression of PAX6 mRNA16341014
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PAX6 mRNA22723015|2493525
C030665triphenyltintriphenyltin results in decreased expression of PAX6 mRNA19031914
D014520UrethaneUrethane results in increased expression of PAX6 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAX6 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PAX6 mRNA22723015|2317975
D014635Valproic AcidValproic Acid results in increased expression of PAX6 mRNA24849673
D014635Valproic AcidValproic Acid affects the expression of PAX6 mRNA17292431|2204503
D014638VanadatesVanadates results in decreased expression of PAX6 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PAX6 gene25560391
D015032ZincZinc deficiency results in decreased expression of PAX6 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20592023  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA20592023  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-TAS10441571  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS10441571  10747901  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0005515protein binding-IPI16098226  
GO:0008134transcription factor binding-ISS-  
GO:0019901protein kinase binding-ISS-  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:0035035histone acetyltransferase binding-ISS-  
GO:0070410co-SMAD binding-IEA-  
GO:0070412R-SMAD binding-IPI17251190  
GO:0071837HMG box domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000132establishment of mitotic spindle orientation-IEA-  
GO:0001568blood vessel development-IMP7550230  
GO:0001654eye development-TAS10747901  
GO:0001709cell fate determination-IEA-  
GO:0001764neuron migration-IEA-  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0002088lens development in camera-type eye-IEA-  
GO:0003309type B pancreatic cell differentiation-IEA-  
GO:0003322pancreatic A cell development-IMP20592023  
GO:0006366transcription by RNA polymerase II-IMP20592023  
GO:0007224smoothened signaling pathway-IEA-  
GO:0007411axon guidance-IEA-  
GO:0007417central nervous system development-TAS10747901  
GO:0007435salivary gland morphogenesis-IEA-  
GO:0007601visual perception-TAS10441571  
GO:0009611response to wounding-IEP17982423  
GO:0009786regulation of asymmetric cell division-IEA-  
GO:0009887animal organ morphogenesis-TAS10441571  
GO:0009950dorsal/ventral axis specification-IEA-  
GO:0010628positive regulation of gene expression-IMP20592023  
GO:0016567protein ubiquitination-IEA-  
GO:0021778oligodendrocyte cell fate specification-IEA-  
GO:0021796cerebral cortex regionalization-IEA-  
GO:0021798forebrain dorsal/ventral pattern formation-IEA-  
GO:0021902commitment of neuronal cell to specific neuron type in forebrain-IEA-  
GO:0021905forebrain-midbrain boundary formation-IEA-  
GO:0021912regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification-IEA-  
GO:0021913regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification-IEA-  
GO:0021918regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment-IEA-  
GO:0021983pituitary gland development-IEA-  
GO:0021986habenula development-IEA-  
GO:0023019signal transduction involved in regulation of gene expression-IEA-  
GO:0030216keratinocyte differentiation-IEA-  
GO:0030334regulation of cell migration-IEA-  
GO:0030858positive regulation of epithelial cell differentiation-IEA-  
GO:0032808lacrimal gland development-IEA-  
GO:0033365protein localization to organelle-IEA-  
GO:0042462eye photoreceptor cell development-IEA-  
GO:0042593glucose homeostasis-IMP11756345  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IMP20592023  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048505regulation of timing of cell differentiation-IEA-  
GO:0048596embryonic camera-type eye morphogenesis-IEA-  
GO:0048663neuron fate commitment-NAS17291498  
GO:0048708astrocyte differentiation-IEA-  
GO:0050680negative regulation of epithelial cell proliferation-IEA-  
GO:0050768negative regulation of neurogenesis-ISS-  
GO:0060041retina development in camera-type eye-IEA-  
GO:0061072iris morphogenesis-IMP7550230  
GO:0061303cornea development in camera-type eye-IMP7550230  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2000178negative regulation of neural precursor cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA20592023  
GO:0005634nucleus-IDA17291498  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA17291498  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-210745Regulation of gene expression in beta cellsIEA
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)TAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27252060ER Stress-induced Aberrant Neuronal Maturation and Neurodevelopmental Disorders. (2016)Kawada KYakugaku Zasshi
22199344Clinical significance of hypermethylation status in NSCLC: evaluation of a 30-gene panel in patients with advanced disease. (2011 Dec)Pesek MAnticancer Res