Gene info: ID 50807

Gene: ASAP1

GENE ID: 50807

Synonyms: AMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14P

Description: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Gene type: protein-coding

Location: 8q24.21-q24.22

dbXrefs: Ensembl:ENSG00000153317 MIM:605953 Vega:OTTHUMG00000164772 UniprotKB:Q9ULH1

RefSeq: NG_030354.1

Retrived from: SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: CD|AD

# Publications: 0

Sherlock p-value : 7.957e-1 (AD) 8.875e-2 (ND) (Frontal_Cortex)

Pascal p-value : 2.054e-1 (AD) 2.581e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10956525	chr8:130430605 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs112765450	chr8:130424403 (GRCh38.p7)	G>A	cocaine dependence	SNV(Single Nucleotide Variation)
rs7004884	chr8:130123023 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18582010	chr8:131415376	ASAP1		1.500e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RALGAPB	0.911
BICD2	0.907
TNFAIP1	0.907
TP53BP1	0.907
UBR1	0.903
ATP2A2	0.902
UBE3A	0.901
KPNA6	0.9
CPSF6	0.9
RPS6KA3	0.9

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.58
OR4F29	-0.533
S100A1	-0.318
COPZ2	-0.314
CTNNA3	-0.31
MYOM1	-0.305
ASB4	-0.297
HEY2	-0.292
MYL3	-0.286
APOM	-0.28

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ASAP1 mRNA"	21346803
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ASAP1 mRNA"	20816883
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP1 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ASAP1 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of ASAP1 gene	27153756
D001151	Arsenic	Arsenic affects the methylation of ASAP1 gene	25304211
D001152	Arsenicals	Arsenicals results in increased methylation of ASAP1 promoter	26039340
D001280	Atrazine	Atrazine results in decreased expression of ASAP1 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ASAP1 mRNA	20064835\|2163298
C006780	bisphenol A	bisphenol A results in decreased expression of ASAP1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ASAP1 gene	28505145
D000069286	Bortezomib	Bortezomib results in decreased expression of ASAP1 mRNA	20977926
D002220	Carbamazepine	Carbamazepine affects the expression of ASAP1 mRNA	24752500
D003042	Cocaine	Cocaine results in decreased expression of ASAP1 mRNA	17898221
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ASAP1 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of ASAP1 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of ASAP1 mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ASAP1 mRNA	23640034
D004008	Diclofenac	Diclofenac affects the expression of ASAP1 mRNA	24752500
C000944	dicrotophos	dicrotophos results in increased expression of ASAP1 mRNA	28302478
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of ASAP1 mRNA"	23811387
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ASAP1 mRNA	22079256
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of ASAP1 mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of ASAP1 mRNA	23649840
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ASAP1 mRNA	25613284
C410337	K 7174	K 7174 results in increased expression of ASAP1 mRNA	24086573
C045463	leflunomide	leflunomide results in increased expression of ASAP1 mRNA	28988120
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of ASAP1 mRNA"	24972896
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ASAP1 mRNA	23649840
D009285	Naphthoquinones	Naphthoquinones results in increased expression of ASAP1 mRNA	23811387
D009532	Nickel	Nickel results in increased expression of ASAP1 mRNA	24768652\|2558310
D016912	Levonorgestrel	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ASAP1 mRNA	19074003
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of ASAP1 mRNA	25729387
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of ASAP1 mRNA	18593933
D010433	Pentylenetetrazole	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of ASAP1 mRNA	21503142
C006253	pirinixic acid	pirinixic acid results in increased expression of ASAP1 mRNA	23811191
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ASAP1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ASAP1 mRNA	22079256
D012989	Soil Pollutants	Soil Pollutants results in increased expression of ASAP1 mRNA	19695345
C010792	testosterone undecanoate	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ASAP1 mRNA	19074003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ASAP1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ASAP1 mRNA	25613284
D014050	Toluene	Toluene results in increased expression of ASAP1 mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of ASAP1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of ASAP1 mRNA	25729387
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of ASAP1 mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in decreased expression of ASAP1 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased expression of ASAP1 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in increased methylation of ASAP1 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ASAP1 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of ASAP1 gene	25560391
D020888	Vigabatrin	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of ASAP1 mRNA	21503142
C025643	vinclozolin	vinclozolin results in increased expression of ASAP1 mRNA	23034163
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP1 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of ASAP1 mRNA	27188386
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of ASAP1 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001786	phosphatidylserine binding	-	IEA	-
GO:0005096	GTPase activator activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12029088 15090612 16636290 17255943 17474147 18786926 19380743 20936779 21706016 21988832
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	-	IEA	-
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	-	IEA	-
GO:0045296	cadherin binding	-	HDA	25468996
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0043547	positive regulation of GTPase activity	-	IEA	-
GO:0060271	cilium assembly	-	IBA	21873635
GO:0060271	cilium assembly	-	IMP	20393563
GO:0061000	negative regulation of dendritic spine development	-	IEA	-
GO:0071803	positive regulation of podosome assembly	-	IBA	21873635
GO:0071803	positive regulation of podosome assembly	-	IEA	-
GO:1903527	positive regulation of membrane tubulation	-	IBA	21873635
GO:1903527	positive regulation of membrane tubulation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002102	podosome	-	IBA	21873635
GO:0002102	podosome	-	IEA	-
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0031253	cell projection membrane	-	IBA	21873635
GO:0031253	cell projection membrane	-	IEA	-
GO:0043197	dendritic spine	-	IEA	-

KEGG ID	KEGG Term
hsa04144	Endocytosis
hsa04666	Fc gamma R-mediated phagocytosis

Reactome ID	Reactome Term	Evidence
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5617833	Cilium Assembly	IEA
R-HSA-5620916	VxPx cargo-targeting to cilium	TAS
R-HSA-5620916	VxPx cargo-targeting to cilium	IEA
R-HSA-5620920	Cargo trafficking to the periciliary membrane	TAS
R-HSA-5620920	Cargo trafficking to the periciliary membrane	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal