Gene: AK3

50808
AK3L1|AK6|AKL3L|AKL3L1|FIX
adenylate kinase 3
protein-coding
9p24.1
Ensembl:ENSG00000147853 MIM:609290 Vega:OTTHUMG00000019472 UniprotKB:Q9UIJ7
NG_028041.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.564e-1 (AD)  6.685e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX50.9
DARS0.892
HADHA0.887
ANP32E0.881
SRI0.874
GLUD10.873
PEX20.871
SEPT20.869
HSDL20.867
PON20.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.637
OR4F29-0.635
OPRD1-0.333
RHO-0.325
KCNG2-0.308
HTR6-0.302
CALHM1-0.298
COL22A1-0.289
LHFPL5-0.288
ADRA1D-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of AK3 mRNA"19162173
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of AK3 mRNA25596134
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AK3 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AK3 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK3 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of AK3 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of AK3 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of AK3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AK3 mRNA]17585979
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of AK3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AK3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AK3 mRNA24449571
D016589AstemizoleAstemizole results in increased expression of AK3 mRNA20221588
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AK3 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of AK3 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of AK3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AK3 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AK3 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AK3 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AK3 mRNA18804290
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of AK3 mRNA25596134
D002746ChlorpromazineChlorpromazine results in decreased expression of AK3 mRNA25596134
C059262cidofovircidofovir results in increased expression of AK3 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of AK3 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of AK3 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of AK3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AK3 mRNA]17585979
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of AK3 mRNA18078969
C018021cobaltous chloridecobaltous chloride results in increased expression of AK3 mRNA19376846
D003042CocaineCocaine affects the expression of AK3 mRNA20187946
D003300CopperCopper results in decreased expression of AK3 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of AK3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of AK3 mRNA25562108|2559613
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AK3 mRNA28628672
D002945CisplatinCisplatin results in increased expression of AK3 mRNA25596134
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of AK3 mRNA23625948
D004237DiuronDiuron results in decreased expression of AK3 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of AK3 mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of AK3 mRNA15033991
D000431EthanolEthanol results in decreased expression of AK3 mRNA17920746
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of AK3 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of AK3 mRNA24793618
D005839GentamicinsGentamicins results in increased expression of AK3 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of AK3 mRNA24136188
D006046GoldGold results in decreased expression of AK3 mRNA25523186
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of AK3 mRNA18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AK3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AK3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AK3 mRNA28628672
D008687MetforminMetformin results in decreased expression of AK3 mRNA25596134
C059539midostaurinmidostaurin results in increased expression of AK3 mRNA20980353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AK3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AK3 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of AK3 mRNA24136188
C022838nickel chloridenickel chloride results in increased expression of AK3 mRNA17312168
D009538NicotineNicotine results in increased expression of AK3 mRNA17456735
D010100OxygenOxygen deficiency results in decreased expression of AK3 mRNA25596134
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of AK3 mRNA23948077
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of AK3 mRNA28973697
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AK3 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of AK3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AK3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AK3 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of AK3 mRNA23811191
C035988procymidoneprocymidone results in increased expression of AK3 mRNA15686871
C045950propiconazolepropiconazole results in decreased expression of AK3 mRNA21278054
D011794QuercetinQuercetin results in increased expression of AK3 mRNA21565894
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of AK3 mRNA16079270
D012524SarinSarin results in decreased expression of AK3 mRNA19522546
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of AK3 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AK3 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of AK3 protein28918527
D013739TestosteroneTestosterone results in decreased expression of AK3 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AK3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AK3 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AK3 protein16548065
D013752TetracyclineTetracycline results in decreased expression of AK3 mRNA24489787
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AK3 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of AK3 mRNA22378314
D014212TretinoinTretinoin results in increased expression of AK3 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of AK3 mRNA15901671
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of AK3 mRNA17982090
D014303TrinitrotolueneTrinitrotoluene affects the expression of AK3 mRNA21346803
C057693troglitazonetroglitazone results in increased expression of AK3 mRNA28973697
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of AK3 mRNA18078969
D014415TunicamycinTunicamycin results in decreased expression of AK3 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of AK3 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of AK3 mRNA17963808
C025643vinclozolinvinclozolin results in increased expression of AK3 mRNA15686871|2257069
D014750VincristineVincristine results in decreased expression of AK3 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of AK3 mRNA19244175
D015032ZincZinc results in decreased expression of AK3 protein15984569
C088658zoledronic acidzoledronic acid results in decreased expression of AK3 mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004017adenylate kinase activityNOTIDA11485571  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0046899nucleoside triphosphate adenylate kinase activity-EXP218813  
GO:0046899nucleoside triphosphate adenylate kinase activity-IDA11485571  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS-  
GO:0016310phosphorylation-IEA-  
GO:0046033AMP metabolic process-IDA11485571  
GO:0046039GTP metabolic process-IDA11485571  
GO:0046041ITP metabolic process-IDA11485571  
GO:0046051UTP metabolic process-IDA11485571  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-ISS11485571  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21698293Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance. (2011)Chang XPLoS One