Gene: TAS2R16

50833
BGLPT|T2R16
taste 2 receptor member 16
protein-coding
7q31.32|7q31
Ensembl:ENSG00000128519 MIM:604867 Vega:OTTHUMG00000157090 UniprotKB:Q9NYV7
NG_011980.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.737e-1 (AD)  5.561e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDY2A0.967
OR5F10.967
TSPY30.967
OR5M10.967
OR5T20.967
KRTAP6-20.967
OR4C120.967
KRTAP27-10.967
OR5W20.967
MAGEB50.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM221-0.292
FUT9-0.278
DBP-0.265
ADCY2-0.26
NOG-0.26
CORO2B-0.26
SLC1A4-0.259
PCDH9-0.259
TM7SF2-0.254
C1orf53-0.252

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0478324-((diethylamino)sulfonyl)benzoic acid4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [salicin results in increased activity of TAS2R16 protein]21629661
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TAS2R16 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TAS2R16 mRNA21298039
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TAS2R16 mRNA"17331233
C006780bisphenol Abisphenol A results in decreased expression of TAS2R16 mRNA25181051
C069837fullerene C60fullerene C60 results in decreased expression of TAS2R16 mRNA19167457
D011339ProbenecidProbenecid binds to and results in decreased activity of TAS2R16 protein21629661
D011339ProbenecidProbenecid inhibits the reaction [salicin results in increased activity of TAS2R16 protein]21629661
C005696salicin4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [salicin results in increased activity of TAS2R16 protein]21629661
C005696salicinProbenecid inhibits the reaction [salicin results in increased activity of TAS2R16 protein]21629661
C005696salicinsalicin results in increased activity of TAS2R16 protein21629661
C017947sodium arsenitesodium arsenite affects the methylation of TAS2R16 gene28589171
D014635Valproic AcidValproic Acid results in decreased methylation of TAS2R16 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0005515protein binding-IPI16720576  
GO:0033038bitter taste receptor activity-IBA21873635  
GO:0033038bitter taste receptor activity-IDA16720576  20022913  
GO ID GO Term Qualifier Evidence PubMed
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IBA21873635  
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IDA16720576  20022913  
GO:0007186G-protein coupled receptor signaling pathway-IC16720576  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA16720576  
GO:0005802trans-Golgi network-IDA16720576  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA16720576  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IC20022913  
KEGG ID KEGG Term
hsa04742Taste transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18524836Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. (2008 Sep)Mangold JEJ Med Genet
16961766The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)Edenberg HJAddict Biol
17250611Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. (2007 Feb)Wang JCAlcohol Clin Exp Res