Gene: CLEC4A

50856
CD367|CLECSF6|DCIR|DDB27|HDCGC13P|LLIR
C-type lectin domain family 4 member A
protein-coding
12p13.31
Ensembl:ENSG00000111729 MIM:605306 Vega:OTTHUMG00000168571 UniprotKB:Q9UMR7
NC_000012.12
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.841e-1 (AD)  3.364e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALPK10.721
LTB4R0.694
WAS0.686
PDCD1LG20.683
RNASET20.667
BTK0.665
HLA-DMA0.664
ZNF7000.661
ARHGAP150.661
DENND1C0.66

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.346
KCNG1-0.335
HNF1A-0.328
CPLX3-0.287
HES5-0.27
GGN-0.267
ST8SIA2-0.265
KLHL34-0.261
PCDHA1-0.26
FBXL18-0.26

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CLEC4A mRNA"19095052
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CLEC4A mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of CLEC4A mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CLEC4A gene27153756
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CLEC4A mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CLEC4A mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CLEC4A mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLEC4A mRNA25993096
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of CLEC4A protein23624239
D003471CuprizoneCuprizone results in increased expression of CLEC4A mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of CLEC4A mRNA21865292
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CLEC4A mRNA28628672
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CLEC4A mRNA25380136
D005054EugenolEugenol results in decreased expression of CLEC4A protein23624239
D004397FonofosFonofos results in increased methylation of CLEC4A promoter22847954
D017313FenretinideFenretinide results in decreased expression of CLEC4A mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CLEC4A mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLEC4A mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CLEC4A mRNA28628672
D007854LeadLead affects the expression of CLEC4A mRNA22313790
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLEC4A mRNA28001369
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CLEC4A mRNA25380136
D009532NickelNickel results in decreased expression of CLEC4A protein23624239
D009532NickelNickel results in increased expression of CLEC4A mRNA25583101
C030110oxaliplatinoxaliplatin results in increased expression of CLEC4A mRNA25729387
D010278ParathionParathion results in increased methylation of CLEC4A promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CLEC4A mRNA19095052
D011441PropylthiouracilPropylthiouracil results in increased expression of CLEC4A mRNA24780913
D020123SirolimusSirolimus results in decreased expression of CLEC4A mRNA21865292
C012568terbufosterbufos results in increased methylation of CLEC4A promoter22847954
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLEC4A mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CLEC4A mRNA16141432
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CLEC4A mRNA"26179874
C025643vinclozolinvinclozolin results in decreased expression of CLEC4A mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of CLEC4A mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS10438934  
GO:0005509calcium ion binding-IDA27015765  
GO:0005537mannose binding-IDA27015765  
GO:0030246carbohydrate binding-IDA27015765  
GO ID GO Term Qualifier Evidence PubMed
GO:0001818negative regulation of cytokine production-IDA18258799  
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0002250adaptive immune response-IEA-  
GO:0002470plasmacytoid dendritic cell antigen processing and presentation-IDA18258799  20530286  
GO:0007155cell adhesion-TAS10438934  
GO:0007166cell surface receptor signaling pathway-TAS10438934  
GO:0032720negative regulation of tumor necrosis factor production-IDA18258799  
GO:0036037CD8-positive, alpha-beta T cell activation-IDA20530286  
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I-IDA20530286  
GO:0045087innate immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10438934  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5621480Dectin-2 familyTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal