Gene info: ID 5087

Gene: PBX1

GENE ID: 5087

Synonyms: CAKUHED

Description: PBX homeobox 1

Gene type: protein-coding

Location: 1q23.3

dbXrefs: Ensembl:ENSG00000185630 MIM:176310 Vega:OTTHUMG00000034307 UniprotKB:P40424

RefSeq: NG_028246.2

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.944e-1 (AD) 1.805e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10494422	chr1:164811778 (GRCh38.p7)	A>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs10494419	chr1:164642664 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg22238122	chr1:164546143	PBX1	Gene body	4.778e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABI2	0.943
NRXN1	0.943
IPO9	0.942
ARHGEF9	0.941
FAM217B	0.936
RAB11FIP2	0.935
TMEM132B	0.935
SMARCA2	0.934
PDPK1	0.933
ASTN1	0.931

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.559
OR4F29	-0.52
CSAG1	-0.46
PGF	-0.418
SGMS2	-0.416
SPINK8	-0.414
TNFRSF12A	-0.412
SFN	-0.408
TFPI2	-0.408
PDZK1IP1	-0.398

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"	25510870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PBX1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PBX1 mRNA"	27188386
D000079	Acetaldehyde	Acetaldehyde affects the expression of PBX1 mRNA	22634333
D000082	Acetaminophen	Acetaminophen results in decreased expression of PBX1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of PBX1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of PBX1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PBX1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PBX1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PBX1 mRNA	19770486
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PBX1 mRNA	24449571
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of PBX1 mRNA"	25351596
D001280	Atrazine	Atrazine results in increased expression of PBX1 mRNA	22378314
C547126	AZM551248	AZM551248 results in increased expression of PBX1 mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of PBX1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PBX1 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PBX1 mRNA	20106945
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PBX1 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PBX1 mRNA"	19150397
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of PBX1 mRNA	17404688
D004958	Estradiol	Estradiol results in decreased expression of PBX1 mRNA	20068009
C006780	bisphenol A	bisphenol A results in increased expression of PBX1 mRNA	20678512\|2927551
C006780	bisphenol A	bisphenol A affects the expression of PBX1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of PBX1 mRNA	29097150
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PBX1 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of PBX1 mRNA	26079696
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PBX1 mRNA	16934159
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA	27858113
C031180	chrysene	chrysene results in decreased expression of PBX1 mRNA	26377693
D003033	Coal Tar	Coal Tar results in decreased expression of PBX1 mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PBX1 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PBX1 mRNA	24386269
D003042	Cocaine	Cocaine results in decreased expression of PBX1 mRNA	17898221
D003042	Cocaine	Cocaine results in increased expression of PBX1 mRNA	17898221
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of PBX1 mRNA	20971185
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of PBX1 mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of PBX1 mRNA	20106945
C093628	cyproconazole	cyproconazole results in increased expression of PBX1 mRNA	22045034
D000069439	Dasatinib	Dasatinib results in increased expression of PBX1 mRNA	20579391
C014347	decitabine	decitabine inhibits the reaction [Smoke results in decreased expression of PBX1 mRNA]	21095227
C014347	decitabine	decitabine results in decreased expression of PBX1 mRNA	27915011
D002945	Cisplatin	PBX1 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in decreased expression of PBX1 mRNA	22023808
D002117	Calcitriol	Calcitriol results in increased expression of PBX1 mRNA	16002434
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PBX1 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PBX1 mRNA	29097150
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of PBX1 mRNA	23649840
C061365	flusilazole	flusilazole affects the expression of PBX1 mRNA	22634333
D017313	Fenretinide	Fenretinide results in increased expression of PBX1 mRNA	28973697
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of PBX1 mRNA"	26377693
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PBX1 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PBX1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PBX1 mRNA	23649840
C008493	methylselenic acid	methylselenic acid results in increased expression of PBX1 mRNA	18548127
D008942	Mitoxantrone	PBX1 protein affects the susceptibility to Mitoxantrone	16217747
C523799	MRK 003	PBX1 results in increased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in increased expression of PBX1 mRNA	15674844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PBX1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PBX1 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of PBX1 mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in decreased expression of PBX1 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of PBX1 mRNA	22714537
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of PBX1 mRNA	20971185
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"	25510870
D010634	Phenobarbital	Phenobarbital affects the expression of PBX1 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PBX1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of PBX1 mRNA	26272509
D010672	Phenytoin	Phenytoin results in increased expression of PBX1 mRNA	20345932
C006253	pirinixic acid	pirinixic acid results in increased expression of PBX1 mRNA	17950772\|1830175
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of PBX1 mRNA]	17950772
D010894	Piroxicam	Piroxicam results in increased expression of PBX1 mRNA	21858171
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of PBX1 mRNA	17404688
C045950	propiconazole	propiconazole results in decreased expression of PBX1 mRNA	16730040\|2127805
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of PBX1 mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of PBX1 mRNA	25351596
D012906	Smoke	decitabine inhibits the reaction [Smoke results in decreased expression of PBX1 mRNA]	21095227
C009277	sodium arsenate	sodium arsenate affects the splicing of PBX1 mRNA	27751817
C009277	sodium arsenate	sodium arsenate results in increased expression of PBX1 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in increased expression of PBX1 mRNA	12760830\|2271453
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PBX1 mRNA	21570461\|2405805
D013853	Thioacetamide	Thioacetamide results in decreased expression of PBX1 mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PBX1 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of PBX1 mRNA	20133372
D014212	Tretinoin	Tretinoin results in increased expression of PBX1 mRNA	21934132\|2383079
D014212	Tretinoin	Tretinoin affects the expression of PBX1 mRNA	22262565
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of PBX1 mRNA	19042947
D014635	Valproic Acid	Valproic Acid results in decreased expression of PBX1 mRNA	23527032\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of PBX1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of PBX1 mRNA	22045034
D014638	Vanadates	Vanadates results in increased expression of PBX1 mRNA	22714537
D002762	Cholecalciferol	Cholecalciferol results in increased expression of PBX1 mRNA	17170073

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	contributes_to	IDA	9079637
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003677	DNA binding	-	IDA	10052460 12412021
GO:0003700	DNA-binding transcription factor activity	-	NAS	10500199
GO:0005515	protein binding	-	IPI	10052460 14701856 15684392 20553494 25609649
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001658	branching involved in ureteric bud morphogenesis	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0006694	steroid biosynthetic process	-	IEA	-
GO:0007221	positive regulation of transcription of Notch receptor target	-	TAS	-
GO:0007548	sex differentiation	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0009952	anterior/posterior pattern specification	-	IEA	-
GO:0009954	proximal/distal pattern formation	-	IEA	-
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	-	IEA	-
GO:0030278	regulation of ossification	-	IEA	-
GO:0030325	adrenal gland development	-	IEA	-
GO:0030326	embryonic limb morphogenesis	-	IEA	-
GO:0035019	somatic stem cell population maintenance	-	TAS	-
GO:0035162	embryonic hemopoiesis	-	IEA	-
GO:0045665	negative regulation of neuron differentiation	-	IEA	-
GO:0048536	spleen development	-	IEA	-
GO:0048538	thymus development	-	IEA	-
GO:0048706	embryonic skeletal system development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	18973687 28270404
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	18973687
GO:0090575	RNA polymerase II transcription factor complex	-	IDA	9079637

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-157118	Signaling by NOTCH	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	TAS
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	IEA
R-HSA-5619507	Activation of HOX genes during differentiation	IEA
R-HSA-9012852	Signaling by NOTCH3	TAS
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27891191	Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood. (2016)	Agha G	Clin Epigenetics
23688269	Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. (2013 May 20)	Mo ML	J Exp Clin Cancer Res