Gene: PBX1

5087
CAKUHED
PBX homeobox 1
protein-coding
1q23.3
Ensembl:ENSG00000185630 MIM:176310 Vega:OTTHUMG00000034307 UniprotKB:P40424
NG_028246.2
PubMed|SNP Mapped
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.944e-1 (AD)  1.805e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10494422chr1:164811778 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs10494419chr1:164642664 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22238122chr1:164546143PBX1Gene body4.778e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABI20.943
NRXN10.943
IPO90.942
ARHGEF90.941
FAM217B0.936
RAB11FIP20.935
TMEM132B0.935
SMARCA20.934
PDPK10.933
ASTN10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.52
CSAG1-0.46
PGF-0.418
SGMS2-0.416
SPINK8-0.414
TNFRSF12A-0.412
SFN-0.408
TFPI2-0.408
PDZK1IP1-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PBX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PBX1 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of PBX1 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of PBX1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PBX1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PBX1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PBX1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PBX1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PBX1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PBX1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of PBX1 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of PBX1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of PBX1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PBX1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PBX1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PBX1 mRNA20106945
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PBX1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PBX1 mRNA"19150397
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PBX1 mRNA17404688
D004958EstradiolEstradiol results in decreased expression of PBX1 mRNA20068009
C006780bisphenol Abisphenol A results in increased expression of PBX1 mRNA20678512|2927551
C006780bisphenol Abisphenol A affects the expression of PBX1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PBX1 mRNA29097150
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PBX1 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of PBX1 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PBX1 mRNA16934159
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PBX1 mRNA27858113
C031180chrysenechrysene results in decreased expression of PBX1 mRNA26377693
D003033Coal TarCoal Tar results in decreased expression of PBX1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of PBX1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of PBX1 mRNA24386269
D003042CocaineCocaine results in decreased expression of PBX1 mRNA17898221
D003042CocaineCocaine results in increased expression of PBX1 mRNA17898221
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PBX1 mRNA20971185
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of PBX1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of PBX1 mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of PBX1 mRNA22045034
D000069439DasatinibDasatinib results in increased expression of PBX1 mRNA20579391
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of PBX1 mRNA]21095227
C014347decitabinedecitabine results in decreased expression of PBX1 mRNA27915011
D002945CisplatinPBX1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in decreased expression of PBX1 mRNA22023808
D002117CalcitriolCalcitriol results in increased expression of PBX1 mRNA16002434
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PBX1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PBX1 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PBX1 mRNA23649840
C061365flusilazoleflusilazole affects the expression of PBX1 mRNA22634333
D017313FenretinideFenretinide results in increased expression of PBX1 mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of PBX1 mRNA"26377693
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PBX1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PBX1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PBX1 mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of PBX1 mRNA18548127
D008942MitoxantronePBX1 protein affects the susceptibility to Mitoxantrone16217747
C523799MRK 003PBX1 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of PBX1 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PBX1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PBX1 mRNA"25554681
D009532NickelNickel results in decreased expression of PBX1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of PBX1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of PBX1 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PBX1 mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PBX1 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of PBX1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PBX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PBX1 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of PBX1 mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of PBX1 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of PBX1 mRNA]17950772
D010894PiroxicamPiroxicam results in increased expression of PBX1 mRNA21858171
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PBX1 mRNA17404688
C045950propiconazolepropiconazole results in decreased expression of PBX1 mRNA16730040|2127805
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of PBX1 mRNA19167446
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PBX1 mRNA25351596
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of PBX1 mRNA]21095227
C009277sodium arsenatesodium arsenate affects the splicing of PBX1 mRNA27751817
C009277sodium arsenatesodium arsenate results in increased expression of PBX1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of PBX1 mRNA12760830|2271453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PBX1 mRNA21570461|2405805
D013853ThioacetamideThioacetamide results in decreased expression of PBX1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PBX1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PBX1 mRNA20133372
D014212TretinoinTretinoin results in increased expression of PBX1 mRNA21934132|2383079
D014212TretinoinTretinoin affects the expression of PBX1 mRNA22262565
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PBX1 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of PBX1 mRNA23527032|2493525
D014635Valproic AcidValproic Acid results in increased expression of PBX1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of PBX1 mRNA22045034
D014638VanadatesVanadates results in increased expression of PBX1 mRNA22714537
D002762CholecalciferolCholecalciferol results in increased expression of PBX1 mRNA17170073

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingcontributes_toIDA9079637  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IDA10052460  12412021  
GO:0003700DNA-binding transcription factor activity-NAS10500199  
GO:0005515protein binding-IPI10052460  14701856  15684392  20553494  25609649  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006694steroid biosynthetic process-IEA-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0007548sex differentiation-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IEA-  
GO:0030278regulation of ossification-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0035019somatic stem cell population maintenance-TAS-  
GO:0035162embryonic hemopoiesis-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0048536spleen development-IEA-  
GO:0048538thymus development-IEA-  
GO:0048706embryonic skeletal system development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA18973687  28270404  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA18973687  
GO:0090575RNA polymerase II transcription factor complex-IDA9079637  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27891191Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood. (2016)Agha GClin Epigenetics
23688269Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. (2013 May 20)Mo MLJ Exp Clin Cancer Res