Gene: PC

5091
PCB
pyruvate carboxylase
protein-coding
11q13.2
Ensembl:ENSG00000173599 MIM:608786 Vega:OTTHUMG00000167099 UniprotKB:P11498
NG_008319.1
PubMed
CD|OD|ND|AD
143   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.757e-2 (AD)  9.866e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDOC0.896
CRAT0.896
ITM2C0.893
CKB0.885
OGDH0.883
LRRC8A0.882
BCKDHA0.869
TRIM80.864
ACO20.861
RXRA0.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.725
OR4F29-0.681
GADL1-0.437
GSDMA-0.408
FER1L6-0.404
GALR1-0.396
DPPA4-0.389
LY9-0.383
CD3G-0.382
GZMK-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PC protein"21673325
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PC protein"27604104
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PC mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PC mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PC mRNA"20959002|2750937
D000082AcetaminophenAcetaminophen results in increased expression of PC protein16538041
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PC mRNA22100608|2715375
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of PC protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PC mRNA28522335
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PC protein26597043
D000638AmiodaroneAmiodarone affects the expression of PC mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of PC mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PC mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PC mRNA25929836
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of PC mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PC mRNA21632981|2231617
D001629BezafibrateBezafibrate results in increased expression of PC mRNA11527545
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of PC mRNA15912405
C006780bisphenol Abisphenol A results in increased methylation of PC gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PC mRNA16799861
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PC mRNA23741332
C055494caffeic acid phenethyl ester[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein28223344
C055494caffeic acid phenethyl esterGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein]28223344
D002220CarbamazepineCarbamazepine results in decreased expression of and results in decreased activity of PC protein12840165
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PC mRNA16239168
D002857ChromiumChromium results in decreased activity of PC protein1245476
D002994ClofibrateClofibrate results in increased expression of PC protein19952500
D002997ClomipramineClomipramine affects the expression of PC mRNA18355885
D003300CopperCopper results in decreased expression of PC mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of PC mRNA20106945|2556210
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PC mRNA26924002
D004026DieldrinDieldrin results in increased expression of PC mRNA20438755
D004041Dietary Fats[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein28223344
D004041Dietary FatsGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein]28223344
D004041Dietary Fats[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein28223344
D004041Dietary Fatstauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein]28223344
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PC mRNA17072980
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of PC mRNA26924002
D004237DiuronDiuron results in increased expression of PC mRNA25152437
C071192entacaponeentacapone binds to PC protein19783845
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PC protein20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PC mRNA17108234
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PC mRNA17557909
C082360fipronilfipronil results in decreased expression of PC mRNA23962444
D005459FluoridesFluorides results in decreased expression of PC protein19497429
D005485FlutamideFlutamide results in decreased expression of PC mRNA24793618
C039281furanfuran results in decreased expression of PC mRNA25539665
D005839GentamicinsGentamicins results in decreased expression of PC protein22061828
D005947GlucosePC protein results in increased oxidation of Glucose23504317
D005947GlucoseGlucose affects the expression of PC mRNA24349266
C412815GW 4064GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein]28223344
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PC mRNA24349266
D007099ImipramineImipramine affects the expression of PC mRNA18355885
D019266Iron, Dietary"Iron, Dietary affects the expression of PC mRNA"15637178
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of PC mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PC mRNA24796395
D007654KetoconazoleKetoconazole affects the expression of PC mRNA18355885
C039798manganese sulfatemanganese sulfate results in decreased expression of PC mRNA23714145
D008627Mercuric ChlorideMercuric Chloride affects the expression of PC mRNA20353558
D008701MethapyrileneMethapyrilene results in decreased expression of PC mRNA16393664
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PC protein27012723
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of PC mRNA16525678
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of PC mRNA24128854
D015735MifepristoneMifepristone results in decreased expression of PC mRNA17584828
D015735MifepristoneMifepristone results in decreased expression of PC mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PC mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of PC mRNA21515302
C051752nefazodonenefazodone results in decreased expression of PC mRNA24136188
D009532NickelNickel results in decreased expression of PC mRNA25583101
D009534NiclosamideNiclosamide results in increased expression of PC mRNA22576131
C012655nimesulidenimesulide results in decreased expression of PC mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of PC protein19716841
C097760N-palmitoylsphingosine[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein]28223344
C464660obeticholic acidobeticholic acid results in decreased expression of PC mRNA27939613
D019301Oleic AcidOleic Acid results in decreased expression of PC mRNA24349266
D010433PentylenetetrazolePentylenetetrazole affects the expression of PC mRNA21503142
D010695PhlorhizinPhlorhizin results in decreased expression of PC mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of PC mRNA11527545
C045950propiconazolepropiconazole results in decreased expression of PC mRNA19423681
C015586propiverinepropiverine binds to PC protein29273565
D011441PropylthiouracilPropylthiouracil results in decreased expression of PC mRNA24780913
C059514resveratrolresveratrol results in decreased expression of PC mRNA23525482
C089730rosiglitazonerosiglitazone affects the expression of PC mRNA21515302
D012643SeleniumSelenium results in increased expression of PC mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of PC mRNA16882884
C017947sodium arsenitesodium arsenite affects the expression of PC mRNA19590694
C017947sodium arsenitesodium arsenite results in increased expression of PC protein24866292
C017947sodium arsenitesodium arsenite results in increased expression of PC protein24866292
C016104sodium bichromatesodium bichromate results in decreased expression of PC mRNA25993096
D013311StreptozocinStreptozocin results in increased expression of PC protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of PC protein]19634143
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein]28223344
C501413tesaglitazartesaglitazar results in increased expression of PC mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PC mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PC mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PC mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PC mRNA16054898|1846511
D013849ThimerosalThimerosal results in decreased expression of PC mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of PC mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PC mRNA28065790
C066340tolcaponetolcapone binds to PC protein19783845
D014212TretinoinTretinoin results in decreased expression of PC mRNA23724009
C032910triadimefontriadimefon results in decreased expression of PC mRNA19423681
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of PC protein]19634143
C057693troglitazonetroglitazone results in increased expression of PC protein18495193
C057693troglitazonetroglitazone results in decreased expression of PC protein21315101
C406224valdecoxibvaldecoxib results in decreased expression of PC mRNA24136188
D014635Valproic AcidValproic Acid results in increased methylation of PC gene29154799
C111237vorinostatvorinostat results in decreased expression of PC mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004736pyruvate carboxylase activity-TAS-  
GO:0005515protein binding-IPI23861867  
GO:0005524ATP binding-IEA-  
GO:0009374biotin binding-IEA-  
GO:0042802identical protein binding-IPI18297087  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006090pyruvate metabolic process-IEA-  
GO:0006094gluconeogenesis-IEA-  
GO:0006094gluconeogenesis-TAS-  
GO:0006629lipid metabolic process-IEA-  
GO:0006768biotin metabolic process-TAS-  
GO:0010629negative regulation of gene expression-IMP23861867  
GO:0019074viral RNA genome packaging-IMP23861867  
GO:0044791positive regulation by host of viral release from host cell-IMP23861867  
GO:0044794positive regulation by host of viral process-IMP23861867  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA23861867  
GO:0005739mitochondrion-IDA16729965  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196780Biotin transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3323169Defects in biotin (Btn) metabolismTAS
R-HSA-3371599Defective HLCS causes multiple carboxylase deficiencyTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28417751Incidence of pancreatic cancer in Greenland 2000-2010. (2012 Jan)Kirkegaard JInt J Circumpolar Health
25461408The variant rs8048002 T>C in intron 3 of the MHC2TA gene is associated with risk of developing acute coronary syndrome. (2015 Feb)Vargas-Alarcon GCytokine
26679360c-Jun, pc-Jun, and p27 are differently expressed in oral leukoplakias in smokers and never-smokers. (2016 Jan)Lima JSOral Surg Oral Med Oral Pathol Oral Radiol
23890140Role of adipocytokines and its correlation with endocrine pancreatic function in patients with pancreatic cancer. (2013 Jul-Aug)Gasiorowska APancreatology
29234928Alterations in acetylcholinesterase and butyrylcholinesterase activities in chronic obstructive pulmonary disease: relationships with oxidative and inflammatory markers. (2017 Dec 12)Ben Anes AMol Cell Biochem
29626481Nicotine induces aberrant hypermethylation of tumor suppressor genes in pancreatic epithelial ductal cells. (2018 May 23)Jin TBiochem Biophys Res Commun
8236135Protein C activity in healthy volunteers--influence of age, sex, smoking and oral contraceptives. (1993 Aug 2)Tait RCThromb Haemost
24341484Effect of combined mutations in the enhancer II and basal core promoter of hepatitis B virus on development of hepatocellular carcinoma in Qidong, China. (2014 Nov)Qu LSHepatol Res
28206989IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFalpha, NR2B, and pC/EBPbeta in the periaqueductal gray in rats. (2017 Apr)Yi HGene Ther
29225000[Validity of the abdominal ecography in primary care for detection of aorta abdominal aneurism in male between 65 and 75 years]. (2017 Dec 7)Bravo-Merino LAten Primaria
26366560RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. (2015)Ojelade SAPLoS One
18006939Assessment of the relation between biomarkers for smoking and biomarkers for acrylamide exposure in humans. (2007 Nov)Vesper HWCancer Epidemiol Biomarkers Prev
21441790Polymorphisms and pancreatic cancer risk: a meta-analysis. (2011 May)Mazaki TEur J Cancer Prev
27574557Utility of different serum fibrosis markers in diagnosing patients with chronic pancreatitis and pancreatic adenocarcinoma. (2016 Aug 15)Kozak AWorld J Gastrointest Oncol
18767931Previous sport activity during childhood and adolescence is associated with increased cortical bone size in young adult men. (2009 Jan)Nilsson MJ Bone Miner Res
7625591Evaluation of the effect of alcohol consumption on erythrocyte lipids and vitamins in a healthy population. (1995 Apr)Simonetti PAlcohol Clin Exp Res
7788664Organophosphate exposure in pesticide formulation and packaging factories in Harare, Zimbabwe. (1995 Feb)Matchaba-Hove RBCent Afr J Med
26493267Randomized phase II study of paclitaxel/carboplatin intercalated with gefitinib compared to paclitaxel/carboplatin alone for chemotherapy-naive non-small cell lung cancer in a clinically selected population excluding patients with non-smoking adenocarcinoma or mutated EGFR. (2015 Oct 22)Choi YJBMC Cancer
29317599DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. (2018 Jan 10)O'Donnell KJTransl Psychiatry
24755888A phase II randomized trial evaluating gefitinib intercalated with pemetrexed/platinum chemotherapy or pemetrexed/platinum chemotherapy alone in unselected patients with advanced non-squamous non-small cell lung cancer. (2014 Jul)Yu HCancer Biol Ther
17288168[Apoptosis of alveolar lymphocytes in sarcoidosis and in control group is more frequent in smokers than in nonsmoking persons]. (2006)Kopinski PPrzegl Lek
7804013Detection by the CAGE of alcoholism or heavy drinking in primary care outpatients and the general population. (1994)Chan AWJ Subst Abuse
26924531Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. (2016 Mar 3)Galinsky KJAm J Hum Genet
24585446Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population. (2015 Sep)Zhu BMol Carcinog
21861928Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells. (2011 Aug 24)Shih RHJ Neuroinflammation
21604947Radical retropubic prostatectomy: a review of outcomes and side-effects. (2011 Jun)Hugosson JActa Oncol
7909277Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer. (1994 May 1)Ebina MCancer Res
26315791Risk Factors for Thrombosis Development in Mexican Patients. (2015 Nov)Zavala-Hernandez CAnn Vasc Surg
14576750Tracing the Mediterranean diet through principal components and cluster analyses in the Greek population. (2003 Nov)Costacou TEur J Clin Nutr
23226539Airway hyperresponsiveness and quality of life in Western red cedar asthmatics removed from exposure. (2012)He JQPLoS One
23193966Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent spontaneous miscarriage in a Tunisian population. (2013 Jan)Messaoudi SGenet Test Mol Biomarkers
16115339Dietary patterns among older Europeans: the EPIC-Elderly study. (2005 Jul)Bamia CBr J Nutr
17433903Inherited thrombophilia in arterial disease: a selective review. (2007 Apr)de Moerloose PSemin Hematol
27978870[Expression and Clinical Significance of PD-1 and PD-L1 in Pulmonary Carcinoids]. (2016 Dec 20)Li MZhongguo Fei Ai Za Zhi
26291032Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. (2015 Nov)Reichel MBiochim Biophys Acta
28577939Cigarette smoke extract induces EGFR-TKI resistance via promoting EGFR signaling pathway and ROS generation in NSCLC cell lines. (2017 Jul)Zhang LLung Cancer
25691252Death receptor 4 variants enhanced prostate cancer risk in North Indian population. (2015 Jul)Mittal RDTumour Biol
11268819Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. (2001)Lieber CSAm J Addict
15003802Genome screen for a combined bone phenotype using principal component analysis: the Framingham study. (2004 Mar)Karasik DBone
24421262Lack of heritability of exhaled volatile compound pattern: an electronic nose twin study. (2014 Mar)Tarnoki DLJ Breath Res
27436845Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors. (2016 Sep 16)Al Mheid ICirc Res
15938221[Risk factors for chronic noncontiguous diseases: twelve-week prospective study]. (2004 Nov-Dec)Lapcevic MSrp Arh Celok Lek
25174478[Association between pancreatic cancer risk and the interaction of U2AF65 gene polymorphisms and smoking]. (2014 Jun)Tian JZhonghua Liu Xing Bing Xue Za Zhi
22614008Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. (2013 Mar 14)Momi NOncogene
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget
18499698Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. (2008 Jun)Suzuki HCarcinogenesis
29514830Progenitor Cells and Clinical Outcomes in Patients With Acute Coronary Syndromes. (2018 May 25)Samman Tahhan ACirc Res
26726887Screening for Chronic Obstructive Pulmonary Disease: Validity and Reliability of a Portable Device in Non-Specialized Healthcare Settings. (2016)Represas-Represas CPLoS One
25726048Demographics, epidemiology, and inheritance of pancreatic ductal adenocarcinoma. (2015 Feb)Yeo TPSemin Oncol
22678356Airway hyperresponsiveness is negatively associated with obesity or overweight status in patients with asthma. (2012)Kwon JWInt Arch Allergy Immunol
15183530Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer. (2004 Jul 16)Granja FCancer Lett
29771029[Related factors of benign paroxysmal positional vertigo:investigation of 310 patients]. (2016 May 5)Liu YLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
22785600The matrix metalloproteinase 2-1575 gene polymorphism is associated with the risk of developing myocardial infarction in Mexican patients. (2012)Perez-Hernandez NJ Atheroscler Thromb
24676794Genetic variants of NQO1 gene increase bladder cancer risk in Indian population and meta-analysis. (2014 Jul)Mandal RKTumour Biol
26371700Pemetrexed plus platinum versus pemetrexed alone in non-small cell lung cancer patients who have progressed after first-line EGFR TKIs. (2015 Nov)Lee SJLung Cancer
2030921Acute effect of passive smoking on lung function and airway responsiveness in asthmatic children. (1991)Oldigs MPediatr Pulmonol
11959031Comparative study of the effects of short- and long-term ethanol treatment and alcohol withdrawal on phospholipid biosynthesis in rat hepatocytes. (2002 Mar)Carrasco MPComp Biochem Physiol B Biochem Mol Biol
26920155Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians. (2016 Jun)Fawzy MSBiochem Genet
19929430Gender-related tumor necrosis factor-alpha responses in naive volunteers with Toll-like receptor 4 polymorphisms exposed in a swine confinement facility. (2009 Dec)Senthilselvan AJ Interferon Cytokine Res
23293117Penile cancer: current therapy and future directions. (2013 May)Sonpavde GAnn Oncol
24616605Platelet activity and sensitivity to agonists after exhaustive treadmill exercise. (2003 Mar)Hilberg TJ Sports Sci Med
17204725Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. (2007 Apr 15)Lazarus SCAm J Respir Crit Care Med
25911935[Genetic aspects of pancreatic cancer]. (2014)Grigor'eva INEksp Klin Gastroenterol
29162857Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)Mamsen LSSci Rep
29650325Improving the genetic signature of prostate cancer, the somatic mutations. (2018 Jun)Martinez-Gonzalez LJUrol Oncol
19150414Genetic predisposition and environmental risk factors to pancreatic cancer: A review of the literature. (2009 Mar-Jun)Landi SMutat Res
9085717Factors affecting the discriminant function analysis of blood chemistry profiles. (1997 Mar-Apr)Welte JWAlcohol
3662082Accuracy of response of six pulse oximeters to profound hypoxia. (1987 Oct)Severinghaus JWAnesthesiology
25916125[Pancreatitis, pancreatic cancer and obesity: hypothesis and facts]. (2014)Grigor'eva INEksp Klin Gastroenterol
16323173Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinoma. (2006 Jan 1)Enokida HCancer
18813773[Prefrontal activity and weekend alcoholism in the young]. (2008)Garcia-Moreno LMAdicciones
21092251Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus. (2010)Anania CArthritis Res Ther
23372645Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers. (2013)Verdugo RAPLoS One
26898612Cigarette smoke extract exposure induces EGFR-TKI resistance in EGFR-mutated NSCLC via mediating Src activation and EMT. (2016 Mar)Li DLung Cancer
29325019Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation. (2018 Mar 15)Zaghlool SBHum Mol Genet
14977086Epidermal growth factor receptor and p53 expression in T1-T2 glottic cancer involving the anterior or posterior commissure. (2004 Jan)Rucci LActa Otolaryngol
27161001Prevalence and factors of elevated alanine aminotransferase in central Taiwan - a retrospective study. (2016 Jun)Lin HFBiomedicine (Taipei)
28246467Familial pancreatic cancer: Concept, management and issues. (2017 Feb 14)Matsubayashi HWorld J Gastroenterol
21558134Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients. (2011)Komenaka IKOncologist
25479908High-risk population in sporadic pancreatic adenocarcinoma: guidelines for screening. (2015 Mar)Bruenderman EHJ Surg Res
24035903The -974C>A (rs3087459) gene polymorphism in the endothelin gene (EDN1) is associated with risk of developing acute coronary syndrome in Mexican patients. (2014 Jun 1)Vargas-Alarcon GGene
26719230Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial. (2016 Apr 2)Zalcman GLancet
15191940Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. (2004 Aug)Kondo TArterioscler Thromb Vasc Biol
16307748Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension. (2006 Sep)Su JAtherosclerosis
16163053Certain background factors exhibit an association with an increased risk for pancreatic calcification among Japanese male alcoholics. (2005 Oct)Nakamura YPancreas
11439293Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. (2001 Jun)Ciccone MInt J Obes Relat Metab Disord
29376046Stages of Biological Development across Age: An Analysis of Canadian Health Measure Survey 2007-2011. (2017)Chao YSFront Public Health
21295903Variability in the performing of spirometry and its consequences in the treatment of COPD in primary care. (2011 May)Monteagudo MArch Bronconeumol
24369272Plasma activity of endothelial lipase impacts high-density lipoprotein metabolism and coronary risk factors in humans. (2014)Sun LJ Atheroscler Thromb
26163088Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial. (2015 Jul)Yahya NRadiother Oncol
20178008Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers. (2010 Sep)Fong PYJ Gastrointest Cancer
7075112Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine. (1982 May)Cook CEClin Pharmacol Ther
15183459Benzo[a]pyrene diol epoxide up-regulates COX-2 expression through NF-kappaB in rat astrocytes. (2004 Jul 15)Weng MWToxicol Lett
19051043Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. (2009 Jul)Dalamaga MCancer Causes Control
18760323Coping with urbanization: a cardiometabolic risk? The THUSA study. (2008 Dec)Malan LBiol Psychol
20484889Comparison of plasma levels of natural anticoagulants (protein C and protein S) among Jordanian smokers and non-smokers. (2010)Al-Sweedan SAActa Haematol
19500157SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. (2009 Aug)Hoft NRGenes Brain Behav
15886801Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage. Results of a multicentre case-control study. (2005 May)Krause MThromb Haemost
21339699Differing age related trajectories of dysfunction in several organ systems in opiate dependence. (2012 Feb)Reece ASAging Clin Exp Res
25386423Study of Auditory, Visual Reaction Time and Glycemic Control (HBA1C) in Chronic Type II Diabetes Mellitus. (2014 Sep)M MJ Clin Diagn Res
22536533Metabolic Syndrome Derived from Principal Component Analysis and Incident Cardiovascular Events: The Multi Ethnic Study of Atherosclerosis (MESA) and Health, Aging, and Body Composition (Health ABC). (2012)Agarwal SCardiol Res Pract
24800806Prehypertension-associated elevation in circulating lysophosphatidlycholines, Lp-PLA2 activity, and oxidative stress. (2014)Kim MPLoS One
6852274Disposition of phencyclidine and its pyrolytic products in mice exposed to smoke. (1983 Jun)Martin BRFed Proc
26677206Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity. (2016 Feb)Jansen RJCancer Epidemiol Biomarkers Prev
19596366[Cost of arterial hypertension according to levels of morbidity in primary care setting]. (2009 Sep 5)Sicras-Mainar AMed Clin (Barc)
21624643Thrombin generation in chronic obstructive pulmonary disease: dependence on plasma factor composition. (2011 Oct)Undas AThromb Res
26221375Association analysis of genetic variants of adiponectin gene and risk of pancreatic cancer. (2015)Yang JPInt J Clin Exp Med
19713246Acquired and inherited risk factors for developing venous thromboembolism in cancer patients receiving adjuvant chemotherapy: a prospective trial. (2010 Apr)Mandala MAnn Oncol
19213780Superoxide dismutases, lung function and bronchial responsiveness in a general population. (2009 May)Siedlinski MEur Respir J
23123068Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults. (2013 Jun)Goncalves LSArch Oral Biol
26339134HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients. (2015)Sippert EAMediators Inflamm
15741445Airway function and markers of airway inflammation in patients with treated hypothyroidism. (2005 Mar)Birring SSThorax
28638788Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer. (2017 Jun 10)Tchio Mantho CIWorld J Clin Oncol
20647474New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts. (2010 Sep 1)Li DClin Cancer Res
15186941Aberrant antibody responses to oxidized LDL and increased intimal thickening in apoE-/- mice exposed to cigarette smoke. (2004 Jul)Tani SAtherosclerosis
19154546Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. (2009 Apr)Hypponen EAllergy
21743088Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset--a prospective cohort study. (2011 Oct)Ajeganova SRheumatology (Oxford)
6983320Bronchial reactivity, smoking, and alpha1-antitrypsin. A population-based study of middle-aged men. (1982 Nov)Kabiraj MUAm Rev Respir Dis
23535363Interferon-gamma promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma. (2013 Jun)Ouyang BToxicol Sci
29268567Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population. (2017 Dec 21)Kim SHCancer Res Treat
22663941Incidence of pancreatic cancer in Greenland 2000-2010. (2012 May 22)Kirkegaard JInt J Circumpolar Health
24411318Synergistic effect of ALOX5AP polymorphisms and cigarette smoking on the risk of atherosclerotic cerebral infarction in a Northern Han Chinese population. (2014 Jun)Yao QJ Clin Neurosci
27988841SO4(=) uptake and catalase role in preconditioning after H2O2-induced oxidative stress in human erythrocytes. (2017 Feb)Morabito RPflugers Arch
25169084[Effects of polymorphisms in XRCC1 and APE1 on vinyl chloride-induced chromosome damage]. (2014 May)Wang JZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
25084000Interaction of Serum microRNAs and Serum Folate With the Susceptibility to Pancreatic Cancer. (2015 Jan)Tian YPancreas
11192332Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy. (2000 Dec)Lieber CSCrit Rev Clin Lab Sci
8729117Polyunsaturation in cell membranes and lipid bilayers and its effects on membrane proteins. (1996 Mar)Slater SJLipids
16733891[Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China]. (2006 Apr)Lu LPZhongguo Yi Xue Ke Xue Yuan Xue Bao
20838719Cardiovascular function and psychological distress in urbanised black South Africans: the SABPA study. (2010 Jul-Aug)Mashele NCardiovasc J Afr
23579732Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence. (2013)Suchankova PPLoS One
22850545Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. (2012)Nakao MJ Epidemiol
27203547Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. (2016 Aug 2)Mitsui YOncotarget
26154566Targeting NK-1 Receptors to Prevent and Treat Pancreatic Cancer: a New Therapeutic Approach. (2015 Jul 6)Munoz MCancers (Basel)
18668269Oral manifestations as predictors of immune suppression in a HIV-/AIDS-infected population in south India. (2009 Jun)Sharma GClin Oral Investig
12671737Genetic determinants of variation in the plasma levels of the C4b-binding protein (C4BP) in Spanish families. (2003 Mar)Esparza-Gordillo JImmunogenetics
25704955Chronic nicotine exposure mediates resistance to EGFR-TKI in EGFR-mutated lung cancer via an EGFR signal. (2015 Apr)Togashi YLung Cancer
26300289The interleukin-1beta-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients. (2015 Nov)Vargas-Alarcon GImmunol Lett
3914938Biotransformation of phencyclidine. (1985-1986)Holsztynska EJDrug Metab Rev
29477594Morphological changes in the cerebellum as a result of ethanol treatment and cigarette smoke exposure: A study on astrogliosis, apoptosis and Purkinje cells. (2018 Apr 13)Wallauer MMNeurosci Lett
29288362Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets. (2018 Feb)Goonesekere NCWJ Cancer Res Clin Oncol
27424921Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C. (2016 Nov)Hanaki TBiochim Biophys Acta
24909166Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages. (2015 Apr 16)Kumar SOncogene
20460356The thrombotic profile of treatment-naive HIV-positive Black South Africans with acute coronary syndromes. (2011 Jun)Becker ACClin Appl Thromb Hemost