Gene: PCBP2

5094
HNRNPE2|HNRPE2|hnRNP-E2
poly(rC) binding protein 2
protein-coding
12q13.13
Ensembl:ENSG00000197111 MIM:601210 Vega:OTTHUMG00000169439 UniprotKB:Q15366
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.409e-1 (AD)  8.430e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB7A0.971
ACTB0.952
SRSF90.948
HNRNPK0.946
CAP10.945
EIF3I0.945
C1orf430.943
ACTG10.942
PSMF10.941
GAPDH0.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.898
OR4F29-0.872
OR6C74-0.173
HMHB1-0.166
MTRNR2L6-0.144
VNN3-0.139
FCRL1-0.139
CETP-0.131
MTRNR2L9-0.126
TCL1A-0.124

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PCBP2 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of PCBP2 mRNA"20406850
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PCBP2 mRNA12958071
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PCBP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCBP2 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to PCBP2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PCBP2 protein]26598702
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in decreased expression of PCBP2 protein"22745752
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCBP2 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of PCBP2 mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of PCBP2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PCBP2 mRNA17562736
D001151ArsenicArsenic affects the methylation of PCBP2 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PCBP2 protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of PCBP2 protein25419056
C006632arsenic trioxidearsenic trioxide results in increased expression of PCBP2 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of PCBP2 mRNA"19446018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCBP2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCBP2 protein20097212
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PCBP2 mRNA20504355|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PCBP2 mRNA"20018196
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PCBP2 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of PCBP2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PCBP2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PCBP2 mRNA20678512
C006780bisphenol Abisphenol A affects the expression of PCBP2 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PCBP2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PCBP2 mRNA29097150
C006780bisphenol Abisphenol A results in increased expression of PCBP2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PCBP2 mRNA26079696
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PCBP2 mRNA19840844
C099555CD 437CD 437 results in decreased expression of PCBP2 mRNA12958071
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PCBP2 gene20938992
D003300CopperCopper results in increased expression of PCBP2 protein21146535
D003375CoumestrolCoumestrol results in decreased expression of PCBP2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of PCBP2 mRNA25562108|2798913
D013759DronabinolDronabinol results in decreased expression of PCBP2 mRNA18454173
D013759DronabinolDronabinol results in increased expression of PCBP2 mRNA16597638
D003703DemecolcineDemecolcine results in increased expression of PCBP2 mRNA23649840
D004026DieldrinDieldrin results in decreased expression of PCBP2 mRNA20584760
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PCBP2 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PCBP2 mRNA16954407
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PCBP2 gene20938992
C001277geldanamycingeldanamycin results in increased expression of PCBP2 mRNA26705709
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PCBP2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PCBP2 mRNA23430699
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PCBP2 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PCBP2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCBP2 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PCBP2 mRNA27544571
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PCBP2 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PCBP2 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCBP2 mRNA19840844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PCBP2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PCBP2 mRNA"25554681|2562005
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PCBP2 mRNA19840844
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PCBP2 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PCBP2 protein19954255
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCBP2 mRNA"27188386
C006253pirinixic acidpirinixic acid results in increased expression of PCBP2 mRNA23811191
C045950propiconazolepropiconazole results in decreased expression of PCBP2 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of PCBP2 mRNA26079696
D011794QuercetinQuercetin results in increased expression of PCBP2 mRNA21565894
D012999SomanSoman results in increased expression of PCBP2 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PCBP2 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCBP2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCBP2 mRNA19840844
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PCBP2 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of PCBP2 protein"25852303
D013849ThimerosalThimerosal results in decreased expression of PCBP2 mRNA27188386
D014520UrethaneUrethane results in increased expression of PCBP2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PCBP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PCBP2 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PCBP2 gene25560391
C111237vorinostatvorinostat results in decreased expression of PCBP2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IDA7607214  
GO:0005515protein binding-IPI9234743  10373504  16713569  17183366  19881509  22720776  
25416956  
GO:0019899enzyme binding-IPI19881509  
GO:0031625ubiquitin protein ligase binding-IPI19881509  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0016070RNA metabolic process-TAS-  
GO:0016071mRNA metabolic process-NAS7556077  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0039694viral RNA genome replication-IDA12414943  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP19881509  
GO:0045087innate immune response-IEA-  
GO:0050687negative regulation of defense response to virus-IMP19881509  
GO:0051607defense response to virus-IEA-  
GO:0075522IRES-dependent viral translational initiation-IDA12414943  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA22720776  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA19029303  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27575817Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis. (2016)Navratilova ZPLoS One