Gene: PDE11A

50940
PPNAD2
phosphodiesterase 11A
protein-coding
2q31.2
Ensembl:ENSG00000284741 MIM:604961 Vega:OTTHUMG00000154188 UniprotKB:Q9HCR9
NG_012168.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.823e-1 (AD)  9.858e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2117740chr2:178025602 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25954134chr2:178941694PDE11AGene body6.696e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C5orf640.738
RASSF20.733
CTNNA30.712
LRRCC10.705
POU2AF10.703
ZEB20.702
C2orf880.697
TCEANC20.691
RHBDL20.69
RMDN10.689

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG1L-0.464
ALOXE3-0.46
NHLH1-0.451
PDE4C-0.45
CBFA2T3-0.435
PSPN-0.416
ASGR2-0.41
CA7-0.408
WNT2-0.405
PRSS12-0.404

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00820TadalafilSmall Molecule171596-29-5Approved|InvestigationalTarget
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE11A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE11A mRNA"27188386
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of PDE11A mRNA]24530881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE11A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE11A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PDE11A mRNA29067470
D000242Cyclic AMPPDE11A protein results in increased hydrolysis of Cyclic AMP10725373
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDE11A mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDE11A gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDE11A mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PDE11A mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDE11A mRNA22316170
C006780bisphenol Abisphenol A affects the expression of PDE11A mRNA21786754
C018475butyraldehydebutyraldehyde results in decreased expression of PDE11A mRNA26079696
D002110CaffeineCaffeine results in decreased expression of PDE11A mRNA20864626
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PDE11A mRNA24763279
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDE11A mRNA24386269
C093628cyproconazolecyproconazole results in decreased expression of PDE11A mRNA22664269
D003976DiazinonDiazinon results in increased expression of PDE11A mRNA17452286
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDE11A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PDE11A mRNA27392435
D004176DipyridamoleDipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP]10725373
C061365flusilazoleflusilazole results in decreased expression of PDE11A mRNA22664269
C010974glyphosateglyphosate results in increased expression of PDE11A mRNA28711546
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PDE11A mRNA24763279
D006152Cyclic GMP1-Methyl-3-isobutylxanthine inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP]10725373
D006152Cyclic GMPDipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP]10725373
D006152Cyclic GMPPDE11A protein results in increased hydrolysis of Cyclic GMP10725373
D006152Cyclic GMPzaprinast inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP]10725373
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of PDE11A mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of PDE11A mRNA24530881
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP]10725373
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDE11A mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PDE11A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDE11A mRNA26752646
D008713MethimazoleMethimazole results in increased expression of PDE11A mRNA22504374
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of PDE11A mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDE11A mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDE11A mRNA20864626
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of PDE11A mRNA20864626
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE11A mRNA"27188386
D011441PropylthiouracilPropylthiouracil results in increased expression of PDE11A mRNA22504374
C502851quinocetonequinocetone results in increased expression of PDE11A mRNA27046791
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDE11A mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of PDE11A gene28589171
D014212TretinoinTretinoin results in increased expression of PDE11A mRNA21934132
D014212TretinoinTretinoin results in decreased expression of PDE11A mRNA20488242|2266426
C032910triadimefontriadimefon results in decreased expression of PDE11A mRNA22664269
C012589trichostatin Atrichostatin A results in increased expression of PDE11A mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PDE11A mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE11A mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of PDE11A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PDE11A mRNA23179753|2627250
C011145zaprinastzaprinast inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP]10725373

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004112cyclic-nucleotide phosphodiesterase activity-NAS10906126  
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity-TAS10725373  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-TAS-  
GO:0004118cGMP-stimulated cyclic-nucleotide phosphodiesterase activity-IDA19689430  
GO:0030553cGMP binding-IDA19689430  
GO:0046872metal ion binding-IEA-  
GO:00475553',5'-cyclic-GMP phosphodiesterase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS10725373  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0008152metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392154Nitric oxide stimulates guanylate cyclaseTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418457cGMP effectsTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal