Gene info: ID 50943

Gene: FOXP3

GENE ID: 50943

Description: forkhead box P3

Gene type: protein-coding

Location: Xp11.23

dbXrefs: Ensembl:ENSG00000049768 MIM:300292 Vega:OTTHUMG00000024135 UniprotKB:Q9BZS1

RefSeq: NG_007392.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 48

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCTD13	0.616
TRIM45	0.606
SLC35C2	0.604
FAM160A2	0.598
RNF31	0.595
KREMEN2	0.593
TECTA	0.589
FOXRED2	0.589
ABCB9	0.589
SLC25A10	0.587

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DLEU1	-0.454
CLEC2B	-0.41
SPINK8	-0.404
MS4A6A	-0.394
LY96	-0.384
ANGPT2	-0.379
CD48	-0.379
TNFAIP8	-0.365
C16orf54	-0.364
IKBIP	-0.364

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of FOXP3 protein"	27589886
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 mRNA]	28867437
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 protein]	28867437
C111855	6-formylindolo(3,2-b)carbazole	"6-formylindolo(3,2-b)carbazole results in increased expression of FOXP3 protein"	25716673
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of FOXP3 gene	27153756
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]	26640276
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of FOXP3 mRNA	21298039
D000638	Amiodarone	Amiodarone results in increased expression of FOXP3 mRNA	19774075
D001151	Arsenic	[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA	23962110
D001151	Arsenic	Arsenic results in increased expression of FOXP3 protein	27289040
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of FOXP3 mRNA	23802174
D001374	Azacitidine	[Azacitidine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein	18493985
D001374	Azacitidine	[Azacitidine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 protein	18493985\|1849398
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of FOXP3 mRNA]	22228805
D004958	Estradiol	"Estradiol inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D004958	Estradiol	"[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of FOXP3 mRNA	19693291
D004958	Estradiol	Estradiol results in decreased expression of FOXP3 mRNA	19693291
C006780	bisphenol A	bisphenol A affects the methylation of FOXP3 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of FOXP3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FOXP3 gene	28505145
D001761	Bleomycin	Bleomycin results in increased expression of FOXP3 mRNA	29033951
D019328	Buthionine Sulfoximine	[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA	23986454
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of FOXP3 mRNA	26177832
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of FOXP3 mRNA	24763279
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of FOXP3 mRNA	15591121
C014347	decitabine	[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein	18567616
C014347	decitabine	[[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IFNG protein	18567616
C014347	decitabine	[[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL17A protein	18567616
C014347	decitabine	[[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL2 protein	18567616
C014347	decitabine	[[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of TNF protein	18567616
C014347	decitabine	[decitabine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 mRNA	18567616\|1856761
C014347	decitabine	[decitabine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 protein	18567616\|1856761
C014347	decitabine	[decitabine co-treated with TGFB1 protein] promotes the reaction [KLF10 protein binds to FOXP3 promoter]	19109157
C014347	decitabine	decitabine results in decreased methylation of FOXP3 promoter	19109157
C014347	decitabine	decitabine results in increased expression of FOXP3 mRNA	19109157
C014347	decitabine	decitabine results in increased expression of FOXP3 protein	19109157\|1954574
C014347	decitabine	TGFB1 protein promotes the reaction [decitabine results in increased expression of FOXP3 protein]	19109157
C007262	deoxynivalenol	deoxynivalenol results in increased expression of FOXP3 mRNA	27757495
C451162	Dermatophagoides pteronyssinus antigen p 1	[Ozone co-treated with Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of FOXP3 mRNA	28529118
C451163	Dermatophagoides pteronyssinus antigen p 2	[Ozone co-treated with Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of FOXP3 mRNA	28529118
D016264	Dextran Sulfate	Dextran Sulfate results in increased methylation of FOXP3 gene	21858153
D016264	Dextran Sulfate	Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased methylation of FOXP3 gene]	21858153
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of FOXP3 mRNA	20881082
D016264	Dextran Sulfate	kappa-casein glycomacropeptide inhibits the reaction [Dextran Sulfate results in increased expression of FOXP3 mRNA]	20881082
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of FOXP3 mRNA	20979868
D004041	Dietary Fats	Dietary Fats results in increased expression of FOXP3 mRNA	25016146
D002117	Calcitriol	Calcitriol results in increased expression of FOXP3	21167785
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOXP3 mRNA	17942748
D005620	Freund's Adjuvant	[COL2A1 protein co-treated with Freund's Adjuvant] results in increased expression of FOXP3 mRNA	25481498
D005620	Freund's Adjuvant	norisoboldine promotes the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased expression of FOXP3 mRNA]	25481498
C070081	fulvestrant	fulvestrant results in increased expression of FOXP3 mRNA	20145137
C070081	fulvestrant	TGFB1 protein promotes the reaction [fulvestrant results in increased expression of FOXP3 mRNA]	20145137
C056933	fumonisin B1	fumonisin B1 results in decreased expression of FOXP3 mRNA	27757495
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of FOXP3 mRNA	24763279
D006830	Hydralazine	Hydralazine results in increased expression of FOXP3 protein	19109157
C020251	kappa-casein glycomacropeptide	kappa-casein glycomacropeptide inhibits the reaction [Dextran Sulfate results in increased expression of FOXP3 mRNA]	20881082
D007840	Latex	Latex analog results in increased expression of FOXP3 mRNA	24768652
D007854	Lead	Lead results in decreased expression of FOXP3 mRNA	19921347
C008261	lead acetate	lead acetate results in increased expression of FOXP3 mRNA	20542052
C008261	lead acetate	lead acetate results in increased expression of FOXP3 protein	23058909
C045463	leflunomide	[leflunomide co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA	26640276
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of FOXP3 protein"	22693607
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FOXP3 mRNA	25896969
D008713	Methimazole	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of FOXP3 mRNA	26177832
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3]	20408897
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate affects the expression of FOXP3 mRNA	20594950
D009532	Nickel	Nickel results in increased expression of FOXP3 mRNA	24768652
C464745	norisoboldine	norisoboldine promotes the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased expression of FOXP3 mRNA]	25481498
C464660	obeticholic acid	obeticholic acid results in increased expression of FOXP3 mRNA	27939613
C446402	ovalbumin-alum	ovalbumin-alum results in decreased expression of FOXP3 mRNA	27884791
C446402	ovalbumin-alum	Plant Extracts inhibits the reaction [ovalbumin-alum results in decreased expression of FOXP3 mRNA]	27884791
D010126	Ozone	[Ozone co-treated with Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of FOXP3 mRNA	28529118
D010126	Ozone	Ozone results in increased expression of FOXP3 mRNA	28529118
D052638	Particulate Matter	CARD9 protein affects the reaction [Particulate Matter results in decreased expression of FOXP3 mRNA]	28315386
D052638	Particulate Matter	Particulate Matter results in decreased expression of FOXP3 mRNA	27832168\|2831538
D010476	Perfume	Perfume results in increased expression of FOXP3 mRNA	24768652
D010672	Phenytoin	[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA	23986454
D010672	Phenytoin	Phenytoin results in decreased expression of FOXP3 mRNA	23986454
D010936	Plant Extracts	Plant Extracts inhibits the reaction [ovalbumin-alum results in decreased expression of FOXP3 mRNA]	27884791
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in decreased expression of FOXP3 protein	25048800
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in increased methylation of FOXP3 gene	25048800
D011342	Procainamide	Procainamide results in increased expression of FOXP3 protein	19109157
D011374	Progesterone	"[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D011374	Progesterone	"Progesterone inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of FOXP3 mRNA	19693291
D011374	Progesterone	Progesterone results in decreased expression of FOXP3 mRNA	19693291
D011796	Quinacrine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 mRNA]	28867437
D011796	Quinacrine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 protein]	28867437
D011796	Quinacrine	FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]	28867437
D011796	Quinacrine	FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]	28867437
D011796	Quinacrine	FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]	28867437
D011796	Quinacrine	Quinacrine results in increased expression of FOXP3 mRNA	28867437
D011796	Quinacrine	Quinacrine results in increased expression of FOXP3 protein	28867437
C059514	resveratrol	resveratrol inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]	26640276
C503639	RG108	RG108 results in increased expression of FOXP3 protein	19109157
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FOXP3 mRNA	25895662
D019821	Simvastatin	Simvastatin results in increased expression of FOXP3	20491794
D019821	Simvastatin	IL2 affects the reaction [Simvastatin results in increased expression of FOXP3]	20408897
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3]	20408897
D019821	Simvastatin	Simvastatin affects the methylation of FOXP3 promoter	20408897
D019821	Simvastatin	Simvastatin results in increased expression of FOXP3	20408897
D019821	Simvastatin	Simvastatin results in decreased expression of FOXP3 mRNA	22305382
D020123	Sirolimus	[TGFB1 protein modified form co-treated with Sirolimus] results in increased expression of FOXP3 mRNA	20844194
D020123	Sirolimus	[TGFB1 protein modified form co-treated with Sirolimus] results in increased expression of FOXP3 protein	20844194
D020123	Sirolimus	Sirolimus results in increased expression of FOXP3 mRNA	20844194
C017947	sodium arsenite	sodium arsenite results in increased expression of FOXP3 mRNA	28843991
C061133	tamibarotene	tamibarotene results in decreased expression of FOXP3 mRNA	22077062
D013629	Tamoxifen	Tamoxifen results in increased expression of FOXP3 mRNA	20145137
D013629	Tamoxifen	TGFB1 protein promotes the reaction [Tamoxifen results in increased expression of FOXP3 mRNA]	20145137
D013739	Testosterone	Testosterone results in increased expression of FOXP3 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FOXP3 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOXP3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased methylation of FOXP3 gene]	21858153
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FOXP3 protein	18684927
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FOXP3 mRNA	18694728
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FOXP3 protein	25716673
C009438	tetrandrine	alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]	26640276
C009438	tetrandrine	resveratrol inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]	26640276
C009438	tetrandrine	[tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA	26640276
C009438	tetrandrine	tetrandrine results in increased expression of FOXP3 mRNA	26640276
D014050	Toluene	Toluene affects the expression of FOXP3 mRNA	21601613
D014050	Toluene	Toluene results in decreased expression of FOXP3 mRNA	19571489\|2205703
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of FOXP3 gene	27618143
C012589	trichostatin A	trichostatin A results in increased expression of FOXP3 protein	19545742
C001899	triptolide	triptolide results in decreased expression of FOXP3 mRNA	24949944
D058425	Vaccines, Virus-Like Particle	"Estradiol inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D058425	Vaccines, Virus-Like Particle	"[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D058425	Vaccines, Virus-Like Particle	"Progesterone inhibits the reaction [Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein]"	20130130
D058425	Vaccines, Virus-Like Particle	"Vaccines, Virus-Like Particle results in decreased expression of FOXP3 protein"	20130130
D014635	Valproic Acid	Valproic Acid results in increased methylation of FOXP3 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of FOXP3 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of FOXP3 mRNA	27832168
D014970	Xanthines	Xanthines results in decreased expression of FOXP3	24646699
D015215	Zidovudine	[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA	23962110

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0003677	DNA binding	-	IMP	21458306
GO:0003700	DNA-binding transcription factor activity	-	IDA	11483607
GO:0003700	DNA-binding transcription factor activity	-	NAS	11138001
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IEA	-
GO:0003714	transcription corepressor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	16652169 17377532 18354202 18368049 20676092 23396208 23543754 23973223 24012345 25416956 25910212
GO:0035035	histone acetyltransferase binding	-	IPI	17360565
GO:0042803	protein homodimerization activity	-	IDA	21458306
GO:0042803	protein homodimerization activity	-	IPI	16920951
GO:0042826	histone deacetylase binding	-	IPI	17360565
GO:0043565	sequence-specific DNA binding	-	IDA	11483607 16873067 19276356
GO:0046872	metal ion binding	-	IEA	-
GO:0051059	NF-kappaB binding	-	NAS	16652169
GO:0051525	NFAT protein binding	-	IPI	16873067 21458306

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001782	B cell homeostasis	-	IEA	-
GO:0001816	cytokine production	-	IEA	-
GO:0002262	myeloid cell homeostasis	-	IEA	-
GO:0002362	CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment	-	TAS	18368049
GO:0002456	T cell mediated immunity	-	IEA	-
GO:0002513	tolerance induction to self antigen	-	IEA	-
GO:0002667	regulation of T cell anergy	-	ISS	-
GO:0002669	positive regulation of T cell anergy	-	IEA	-
GO:0002677	negative regulation of chronic inflammatory response	-	IEA	-
GO:0002725	negative regulation of T cell cytokine production	-	IDA	15466453
GO:0002725	negative regulation of T cell cytokine production	-	IMP	23169781
GO:0002851	positive regulation of peripheral T cell tolerance induction	-	IEA	-
GO:0006338	chromatin remodeling	-	NAS	16903909
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	NAS	11138001
GO:0008285	negative regulation of cell proliferation	-	IDA	15652505
GO:0009615	response to virus	-	IEP	20583921
GO:0030111	regulation of Wnt signaling pathway	-	TAS	-
GO:0031064	negative regulation of histone deacetylation	-	IGI	19276356
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IDA	16652169
GO:0032689	negative regulation of interferon-gamma production	-	IDA	15466453
GO:0032689	negative regulation of interferon-gamma production	-	IMP	23169781
GO:0032693	negative regulation of interleukin-10 production	-	IDA	15466453
GO:0032700	negative regulation of interleukin-17 production	-	IMP	18368049
GO:0032703	negative regulation of interleukin-2 production	-	IDA	15466453 17360565 17377532
GO:0032703	negative regulation of interleukin-2 production	-	IMP	23169781
GO:0032713	negative regulation of interleukin-4 production	-	IDA	15466453
GO:0032714	negative regulation of interleukin-5 production	-	IEA	-
GO:0032715	negative regulation of interleukin-6 production	-	IEA	-
GO:0032720	negative regulation of tumor necrosis factor production	-	IEA	-
GO:0032753	positive regulation of interleukin-4 production	-	IEA	-
GO:0032792	negative regulation of CREB transcription factor activity	-	IDA	16652169
GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	-	TAS	18368049
GO:0032914	positive regulation of transforming growth factor beta1 production	-	IEA	-
GO:0033092	positive regulation of immature T cell proliferation in thymus	-	IEA	-
GO:0035066	positive regulation of histone acetylation	-	IMP	19276356
GO:0035067	negative regulation of histone acetylation	-	IEA	-
GO:0042036	negative regulation of cytokine biosynthetic process	-	IDA	11483607
GO:0042110	T cell activation	-	IDA	15466453
GO:0042130	negative regulation of T cell proliferation	-	IDA	15466453
GO:0042130	negative regulation of T cell proliferation	-	IMP	21458306 23169781
GO:0043029	T cell homeostasis	-	NAS	11483607
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IDA	16873067
GO:0045077	negative regulation of interferon-gamma biosynthetic process	-	IEA	-
GO:0045085	negative regulation of interleukin-2 biosynthetic process	-	IMP	16873067
GO:0045589	regulation of regulatory T cell differentiation	-	TAS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	11483607 16920951 17360565 22678915
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	21458306 23169781
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	15466453
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	19276356 21458306 23169781
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	19276356
GO:0046007	negative regulation of activated T cell proliferation	-	NAS	11483607
GO:0048294	negative regulation of isotype switching to IgE isotypes	-	IEA	-
GO:0048302	regulation of isotype switching to IgG isotypes	-	IEA	-
GO:0050710	negative regulation of cytokine secretion	-	IDA	11483607
GO:0050777	negative regulation of immune response	-	IDA	15652505
GO:0050852	T cell receptor signaling pathway	-	IEA	-
GO:2000320	negative regulation of T-helper 17 cell differentiation	-	IMP	23169781

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	11483607 16873067 16920951 22678915 24012345
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	22678915
GO:0032991	protein-containing complex	-	NAS	16903909

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28789387	Urinary levels of prostaglandin E2 are positively correlated with intratumoral infiltration of Foxp3(+) regulatory T cells in non-small cell lung cancer. (2017 Aug)	Shimizu K	Oncol Lett
26808506	Cigarette Smoke Disturbs the Survival of CD8+ Tc/Tregs Partially through Muscarinic Receptors-Dependent Mechanisms in Chronic Obstructive Pulmonary Disease. (2016)	Chen G	PLoS One
22969801	Predictors of immunosuppressive regulatory T lymphocytes in healthy women. (2012)	Hampras SS	J Cancer Epidemiol
24527405	Epigenetic regulation in allergic diseases and related studies. (2014 Jan)	Kuo CH	Asia Pac Allergy
22701274	Erythromycin enhances CD4+Foxp3+ regulatory T-cell responses in a rat model of smoke-induced lung inflammation. (2012)	Bai J	Mediators Inflamm
28705478	Increased innate and adaptive immune responses in induced sputum of young smokers. (2015)	Kislina A	Medicina (Kaunas)
28658564	A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype. (2017 Nov)	Hirai K	Clin Exp Allergy
27502728	Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer. (2016 Nov)	Kinoshita T	Ann Oncol
25867464	Smoking worsens multiple sclerosis prognosis: two different pathways are involved. (2015 Apr 15)	Correale J	J Neuroimmunol
23421612	Increased bronchial density of CD25+Foxp3+ regulatory T cells in occupational asthma: relationship to current smoking. (2013 May)	Sjaheim TB	Scand J Immunol
27841362	PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients. (2016 Nov 14)	Kim HR	Sci Rep
23978443	Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers. (2014 Feb)	Herberth G	J Allergy Clin Immunol
20489056	Hypomorphic Rag mutations can cause destructive midline granulomatous disease. (2010 Aug 26)	De Ravin SS	Blood
29311129	Regulatory T Cells: From Discovery to Autoimmunity. (2018 Jan 8)	Kitz A	Cold Spring Harb Perspect Med
24512045	Chronic ethanol feeding induces subset loss and hyporesponsiveness in skin T cells. (2014 May)	Parlet CP	Alcohol Clin Exp Res
22187950	Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. (2012 Mar)	Hinz D	Allergy
22955940	Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms. Relationship to clinical risk factors. (2012 Nov)	Sagan A	Thromb Haemost
25329073	Treg/IL-17 ratio and Treg differentiation in patients with COPD. (2014)	Jin Y	PLoS One
18642789	[Correlation between FoxP3(+) regulatory T cells and chronic obstructive pulmonary disease]. (2008 Feb 19)	Xiong XZ	Zhonghua Yi Xue Za Zhi
20979845	[Effect of cigarette smoke exposure on the percentage of CD(4)(+)CD(25)(+) regulatory T cells and the expression of transcription factor Foxp3 in asthmatic rats]. (2010 Aug)	Jiang Y	Zhonghua Jie He He Hu Xi Za Zhi
21092638	[CD(4)(+)Foxp3(+) regulatory T cells in inflammation and emphysema after smoking cessation in rats]. (2010 Sep)	Qiu SL	Zhonghua Jie He He Hu Xi Za Zhi
20731586	Role of smoking and type 2 diabetes in the immunobalance of advanced chronic periodontitis. (2011 Mar)	Duarte PM	J Periodontol
25390734	Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis. (2014 Dec 15)	O'Leary SM	Am J Respir Crit Care Med
29515587	T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder. (2018)	Patas K	Front Immunol
25231450	Thyroid autoimmunity. (2014)	Wiersinga WM	Endocr Dev
18252008	Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells? (2008 Feb 6)	Brandsma CA	Respir Res
27153545	Clinicopathological and prognostic significance of regulatory T cells in patients with non-small cell lung cancer: A systematic review with meta-analysis. (2016 Jun 14)	Zhao S	Oncotarget
25480659	DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle? (2016 Feb)	Nielsen CH	Arch Toxicol
21092462	[Change of airway inflammation induced by Th1/Tc1 and the expression of T regulatory cells in smoking cessation rats]. (2010 Sep 28)	HUANG QP	Zhonghua Yi Xue Za Zhi
28332605	Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure. (2017 Mar 23)	Roth-Walter F	Sci Rep
23036591	Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)	Kazantseva MG	Arthritis Res Ther
24274151	Prenatal exposure to cigarette smoke alters later-life antitumor cytotoxic T-lymphocyte (CTL) activity via possible changes in T-regulatory cells. (2013)	Ng SP	J Toxicol Environ Health A
27252415	Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients. (2016 Dec 15)	Parra ER	Clin Cancer Res
20961621	Within-woman change in regulatory T cells from pregnancy to the postpartum period. (2011 Jan)	Wegienka G	J Reprod Immunol
25990808	Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years. (2015 May 20)	Paaso A	J Transl Med
22288596	Bronchoalveolar lavage cell pattern from healthy human lung. (2012 Mar)	Heron M	Clin Exp Immunol
28950145	Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma. (2017 Nov)	Kinoshita T	Eur J Cancer
24779222	[Classification and etiology of hyperthyroidism]. (2014 Mar)	Lacka K	Pol Merkur Lekarski
21784975	Cytokine-induced alterations of alpha7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. (2011 Sep 1)	Galitovskiy V	J Immunol
24691114	Opposing effects of smoking in ulcerative colitis and Crohn's disease may be explained by differential effects on dendritic cells. (2014 May)	Ueno A	Inflamm Bowel Dis
22652413	Increased intraepithelial (CD103+) CD8+ T cells in the airways of smokers with and without chronic obstructive pulmonary disease. (2013 Feb)	Mikko M	Immunobiology
21651772	Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD. (2011 Jun 8)	Roos-Engstrand E	Respir Res
24203779	A novel cytomegalovirus-induced regulatory-type T-cell subset increases in size during older life and links virus-specific immunity to vascular pathology. (2014 May 1)	Terrazzini N	J Infect Dis
22878868	Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis. (2013 Feb 1)	Julian MW	Chest
26604855	The prognostic influence of tumor infiltrating Foxp3(+)CD4(+), CD4(+) and CD8(+) T cells in resected non-small cell lung cancer. (2015)	Jackute J	J Inflamm (Lond)
25097153	Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD). (2014 Dec)	Tan DB	Immunobiology
25001933	[Imbalance in the expression of Foxp3, T-bet and GATA-3 is correlated with inflammation of chronic obstructive pulmonary disease]. (2014 Jul)	Wang C	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
27095786	[Effect of CD40 on Foxp3(+) Treg cell in the lung of cigarette smoke exposure mice]. (2016 Apr 12)	Deng TT	Zhonghua Yi Xue Za Zhi