Gene info: ID 5095

Gene: PCCA

GENE ID: 5095

Synonyms: -

Description: propionyl-CoA carboxylase subunit alpha

Gene type: protein-coding

Location: 13q32.3

dbXrefs: Ensembl:ENSG00000175198 MIM:232000 Vega:OTTHUMG00000017284 UniprotKB:P05165

RefSeq: NG_008768.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.701e-1 (AD) 8.996e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs681561	chr13:100246275 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg26574777	chr13:100927476	PCCA		1.100e-14	Smoking	27651444
cg15559940	chr13:101171765	PCCA		5.700e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPT1	0.905
RBBP4	0.896
RPA1	0.892
LARS	0.892
VPS45	0.889
WDR48	0.886
SLC39A9	0.885
PEX19	0.883
DHX9	0.878
KPNB1	0.877

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.73
OR4F29	-0.677
OR6C74	-0.244
MTRNR2L6	-0.239
TNFRSF13B	-0.232
KLRB1	-0.231
MTRNR2L10	-0.216
C8orf74	-0.211
CLEC6A	-0.209
MTRNR2L9	-0.206

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PCCA protein"	27604104
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PCCA mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PCCA mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in decreased expression of PCCA mRNA	25704631\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of PCCA mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of PCCA protein	21329376
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PCCA protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PCCA mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PCCA mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of PCCA mRNA	21757418
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of PCCA protein	26597043
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PCCA mRNA	22521957
D001280	Atrazine	Atrazine results in increased expression of PCCA mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PCCA mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PCCA mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PCCA mRNA	19770486\|2071347
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PCCA mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PCCA mRNA"	26238291
D004958	Estradiol	Estradiol affects the expression of PCCA mRNA	23557687
C044887	beta-methylcholine	beta-methylcholine affects the expression of PCCA mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of PCCA mRNA	23557687
C006780	bisphenol A	bisphenol A results in increased expression of PCCA mRNA	25181051
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PCCA mRNA	23650126
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PCCA mRNA	20938992
C041167	chromium nitrate	chromium nitrate results in increased expression of PCCA protein	22144121
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PCCA mRNA	24386269
D016572	Cyclosporine	Cyclosporine results in decreased expression of PCCA mRNA	20106945
D013759	Dronabinol	Dronabinol results in increased expression of PCCA mRNA	16616335
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PCCA mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PCCA mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of PCCA mRNA	23625948
C000944	dicrotophos	dicrotophos results in decreased expression of PCCA mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of PCCA mRNA	18042831
D004237	Diuron	Diuron results in decreased expression of PCCA mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in decreased expression of PCCA mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of PCCA protein	26873546
D004726	Endosulfan	Endosulfan results in decreased expression of PCCA protein	26722802
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PCCA mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PCCA mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PCCA mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCCA mRNA	17942748
D005485	Flutamide	Flutamide results in decreased expression of PCCA mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PCCA mRNA	20938992
D019833	Genistein	Genistein results in increased expression of PCCA mRNA	26865667
D005897	Glafenine	Glafenine results in decreased expression of PCCA mRNA	24136188
C410337	K 7174	K 7174 results in increased expression of PCCA mRNA	24086573
C005095	malachite green	malachite green results in increased expression of PCCA protein	22446826
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PCCA mRNA	20938992
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of PCCA protein	19716841
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of PCCA mRNA	25729387
D017239	Paclitaxel	Paclitaxel results in decreased expression of PCCA protein	15907983
D000073878	Palm Oil	Palm Oil results in decreased expression of PCCA mRNA	18042831
D010695	Phlorhizin	Phlorhizin results in decreased expression of PCCA mRNA	22538082
C006253	pirinixic acid	pirinixic acid results in increased expression of PCCA mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in increased expression of PCCA mRNA	23557933
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PCCA mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PCCA mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of PCCA protein	22144121
D011374	Progesterone	Progesterone results in decreased expression of PCCA mRNA	23018184
D011374	Progesterone	Progesterone results in increased expression of PCCA mRNA	23018184
D011374	Progesterone	Progesterone results in decreased expression of PCCA mRNA	21540246
D011374	Progesterone	Progesterone results in increased expression of PCCA mRNA	20726854
D011794	Quercetin	Quercetin results in decreased expression of PCCA mRNA	21632981
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PCCA mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in decreased expression of PCCA mRNA	21297353
C016104	sodium bichromate	sodium bichromate affects the expression of PCCA mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in decreased expression of PCCA mRNA	25993096
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCCA mRNA	17942748
C009495	titanium dioxide	titanium dioxide results in decreased expression of PCCA mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of PCCA mRNA	25729387
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of PCCA protein	24685621
D014415	Tunicamycin	Tunicamycin results in increased expression of PCCA mRNA	22378314
D014415	Tunicamycin	Tunicamycin results in decreased expression of PCCA mRNA	17127020
D014635	Valproic Acid	Valproic Acid affects the expression of PCCA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PCCA gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of PCCA mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of PCCA gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of PCCA mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of PCCA mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PCCA mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004658	propionyl-CoA carboxylase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	20725044
GO:0005524	ATP binding	-	IEA	-
GO:0009374	biotin binding	-	TAS	3460076
GO:0019899	enzyme binding	-	IPI	19157941
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006768	biotin metabolic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00280	Valine, leucine and isoleucine degradation
hsa00630	Glyoxylate and dicarboxylate metabolism
hsa00640	Propanoate metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-196780	Biotin transport and metabolism	TAS
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-3296482	Defects in vitamin and cofactor metabolism	TAS
R-HSA-3323169	Defects in biotin (Btn) metabolism	TAS
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-71032	Propionyl-CoA catabolism	TAS
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	TAS
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal