Gene: SOST

50964
CDD|DAND6|SOST1|VBCH
sclerostin
protein-coding
17q21.31
Ensembl:ENSG00000167941 MIM:605740 Vega:OTTHUMG00000180888 UniprotKB:Q9BQB4
NG_008078.2
PubMed
0   ANCO-SNPs
ND
2   
6.883e-1 (AD)  4.883e-1 (ND)   (Frontal_Cortex)
8.167e-1 (AD)  4.310e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL17REL0.635
MEI10.581
CYP26A10.54
ADTRP0.532
NPFFR20.528
MYH40.525
FOXP20.52
THEMIS0.513
POSTN0.51
GALNT140.498

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3-0.374
AHNAK-0.361
YAP1-0.358
ARHGAP31-0.354
MRO-0.352
SLC2A4-0.346
TMEM100-0.341
RANBP3L-0.341
LPP-0.336
CGNL1-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SOST mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SOST mRNA]22019892
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SOST mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SOST mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SOST mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SOST mRNA16483693
C485817beta-tricalcium phosphatebeta-tricalcium phosphate results in increased expression of SOST mRNA22522029
D001663BilirubinBilirubin results in decreased expression of SOST mRNA20196124
C006780bisphenol Abisphenol A results in increased methylation of SOST promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SOST mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SOST gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of SOST mRNA26079696
D019256Cadmium Chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SOST mRNA]22019892
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SOST mRNA22019892
D002220CarbamazepineCarbamazepine affects the expression of SOST mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SOST mRNA23914054
D003907DexamethasoneDexamethasone inhibits the reaction [BMP2 protein results in increased expression of SOST mRNA]15268896
D003907DexamethasoneDexamethasone inhibits the reaction [BMP4 protein results in increased expression of SOST mRNA]15268896
D003907DexamethasoneDexamethasone inhibits the reaction [BMP6 protein results in increased expression of SOST mRNA]15268896
D004041Dietary FatsDietary Fats results in increased expression of SOST mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of SOST mRNA26033743
D002117CalcitriolCalcitriol promotes the reaction [BMP2 protein results in increased expression of SOST mRNA]15268896
D002117CalcitriolCalcitriol promotes the reaction [BMP4 protein results in increased expression of SOST mRNA]15268896
D002117CalcitriolCalcitriol promotes the reaction [BMP6 protein results in increased expression of SOST mRNA]15268896
C074031exenatideexenatide results in increased expression of SOST mRNA19586609
D004397FonofosFonofos results in increased methylation of SOST promoter22847954
D007854LeadLead results in increased expression of SOST protein23086611
D007854LeadLead results in increased expression of SOST protein23086611
C042720mercuric bromidemercuric bromide results in increased expression of SOST mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
C568376MT19c compoundMT19c compound results in decreased expression of SOST mRNA21781307
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
D010278ParathionParathion results in increased methylation of SOST promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOST mRNA"27188386
D010938Plant OilsPlant Oils results in increased expression of SOST mRNA23370395
C017947sodium arsenitesodium arsenite results in increased expression of SOST mRNA28595984
C012568terbufosterbufos results in increased methylation of SOST promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOST mRNA24035824
D014212TretinoinTretinoin promotes the reaction [BMP2 protein results in increased expression of SOST mRNA]15268896
D014212TretinoinTretinoin promotes the reaction [BMP4 protein results in increased expression of SOST mRNA]15268896
D014212TretinoinTretinoin promotes the reaction [BMP6 protein results in increased expression of SOST mRNA]15268896
D014635Valproic AcidValproic Acid results in increased expression of SOST mRNA23179753|2718838
C029297vinylidene chloridevinylidene chloride results in decreased expression of SOST mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15908424  21471202  21944579  
GO:0008134transcription factor binding-IDA17696759  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0009612response to mechanical stimulus-IEP21723865  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030279negative regulation of ossification-NAS11181578  17696759  
GO:0030514negative regulation of BMP signaling pathway-IDA14633986  
GO:0031333negative regulation of protein complex assembly-IDA15908424  
GO:0045893positive regulation of transcription, DNA-templated-IMP17696759  
GO:0071374cellular response to parathyroid hormone stimulus-IDA17696759  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA15908424  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS-  
GO:2000054negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification-IDA15908424  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0032991protein-containing complex-IEA-  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29243300Antagonists of Wnt/beta-catenin signalling in the periodontitis associated with type 2 diabetes and smoking. (2018 Mar)Miranda TSJ Clin Periodontol
25854266Osteoprotegerin and sclerostin in chronic kidney disease prior to dialysis: potential partners in vascular calcifications. (2015 Aug)Morena MNephrol Dial Transplant