Gene: PCDH8

5100
ARCADLIN|PAPC
protocadherin 8
protein-coding
13q14.3
Ensembl:ENSG00000136099 MIM:603580 Vega:OTTHUMG00000016979 UniprotKB:O95206
NC_000013.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.318e-2 (AD)  6.060e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBLN40.914
VSTM2A0.896
IGSF30.889
NDST30.885
LAMP50.884
CUX20.884
LRRTM10.882
PIP5K1B0.88
DGKB0.879
CDH220.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.612
TGFB3-0.573
SEPT10-0.57
VRK2-0.569
MYL3-0.557
FAM114A1-0.555
SGMS2-0.553
ZFP57-0.551
BCAS1-0.548
WIPF1-0.548

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PCDH8 mRNA"27291303
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PCDH8 mRNA"20206263
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of PCDH8 mRNA24140754
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of PCDH8 mRNA22634333
C016601afimoxifeneafimoxifene results in increased expression of PCDH8 mRNA19901195
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCDH8 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of PCDH8 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCDH8 mRNA16483693
C015001arsenitearsenite results in increased methylation of PCDH8 promoter23974009
C487081belinostatbelinostat results in increased expression of PCDH8 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCDH8 mRNA27195522
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PCDH8 mRNA19619570
D004958EstradiolEstradiol results in increased expression of PCDH8 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of PCDH8 mRNA24465770
D002104CadmiumCadmium affects the expression of PCDH8 mRNA21120746
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDH8 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PCDH8 mRNA26272509
D003042CocaineCocaine results in increased expression of PCDH8 mRNA18000554
D003042CocaineCocaine results in increased expression of PCDH8 protein18000554
D003471CuprizoneCuprizone results in increased expression of PCDH8 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PCDH8 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PCDH8 mRNA]27941970
D019422Dietary SucroseDietary Sucrose results in increased expression of PCDH8 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PCDH8 mRNA25242112
C118739entinostatentinostat results in increased expression of PCDH8 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C061365flusilazoleflusilazole affects the expression of PCDH8 mRNA22634333
C412815GW 4064GW 4064 results in increased expression of PCDH8 mRNA26655953
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDH8 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCDH8 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PCDH8 mRNA26272509
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PCDH8 mRNA20864626
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PCDH8 mRNA26924002
D009532NickelNickel results in decreased expression of PCDH8 mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PCDH8 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PCDH8 mRNA26705709
D010936Plant ExtractsPlant Extracts results in decreased expression of PCDH8 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of PCDH8 mRNA24780913
D012999SomanSoman results in increased expression of PCDH8 mRNA19281266
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PCDH8 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCDH8 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PCDH8 mRNA19901195
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCDH8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PCDH8 mRNA19465110
D014212TretinoinTretinoin results in increased expression of PCDH8 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH8 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PCDH8 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of PCDH8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PCDH8 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of PCDH8 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PCDH8 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PCDH8 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PCDH8 gene25560391
C025643vinclozolinvinclozolin results in increased expression of PCDH8 mRNA22615374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001756somitogenesis-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007267cell-cell signaling-TAS9787079  
GO:0007268chemical synaptic transmission-IEA-  
GO:0016331morphogenesis of embryonic epithelium-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS9787079  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9787079  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0042734presynaptic membrane-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18000554Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (2007 Nov 14)Mash DCPLoS One