Gene: PCDH9

5101
-
protocadherin 9
protein-coding
13q21.32
Ensembl:ENSG00000184226 MIM:603581 Vega:OTTHUMG00000017040 UniprotKB:Q9HC56
NG_011876.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.576e-3 (AD)  1.186e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9540953chr13:66949126 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17791001chr13:66946882 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1982305chr13:66334267 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23126342chr13:67801125PCDH93.100e-12Smoking27651444
cg23126342chr13:67801125PCDH91.850e-8Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM20.908
MEGF90.879
NCAM10.869
PHYHIPL0.869
EXOC6B0.868
EPS150.866
OSBPL1A0.859
FBXW110.858
JAKMIP20.855
CLASP20.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.599
OR4F5-0.594
FCER2-0.468
DPPA4-0.464
SIX1-0.462
FOXI2-0.445
TRIM10-0.439
ABCA13-0.438
TFPI2-0.433
PDE6G-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of PCDH9 mRNA23792671
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCDH9 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PCDH9 mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCDH9 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCDH9 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCDH9 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCDH9 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PCDH9 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PCDH9 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PCDH9 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCDH9 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of PCDH9 mRNA21757418
D001151ArsenicArsenic affects the methylation of PCDH9 gene25304211
C015001arsenitearsenite results in increased expression of PCDH9 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of PCDH9 mRNA]18929588
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of PCDH9 mRNA"18687144
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PCDH9 mRNA"20382639
D004958EstradiolEstradiol affects the expression of PCDH9 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PCDH9 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of PCDH9 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PCDH9 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of PCDH9 mRNA26079696
D002509CephaloridineCephaloridine results in decreased expression of PCDH9 mRNA18500788
D019327Copper SulfateCopper Sulfate results in decreased expression of PCDH9 mRNA19020976
C030973cupric oxidecupric oxide results in decreased expression of PCDH9 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of PCDH9 mRNA20106945|2798913
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PCDH9 mRNA]27941970
D002945CisplatinCisplatin results in increased expression of PCDH9 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PCDH9 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PCDH9 mRNA17005392
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PCDH9 mRNA"27840820
C118739entinostatentinostat results in decreased expression of PCDH9 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCDH9 mRNA29097150
D005557FormaldehydeFormaldehyde results in increased expression of PCDH9 mRNA20655997
C042720mercuric bromidemercuric bromide results in increased expression of PCDH9 mRNA26272509
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PCDH9 mRNA23179753|2800136
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PCDH9 mRNA24810058
D009532NickelNickel results in decreased expression of PCDH9 mRNA25583101
D010100OxygenOxygen deficiency results in decreased expression of PCDH9 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PCDH9 mRNA"25510870
C046012pentanalpentanal results in decreased expression of PCDH9 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PCDH9 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PCDH9 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PCDH9 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PCDH9 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of PCDH9 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PCDH9 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PCDH9 mRNA22300531
C017947sodium arsenitesodium arsenite affects the methylation of PCDH9 gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of PCDH9 mRNA23274088
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of PCDH9 gene26864933
D014212TretinoinTretinoin results in increased expression of PCDH9 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PCDH9 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in increased expression of PCDH9 mRNA17127020
D014520UrethaneUrethane results in decreased expression of PCDH9 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCDH9 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PCDH9 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PCDH9 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of PCDH9 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PCDH9 mRNA23179753|2438349
C111237vorinostatvorinostat results in increased expression of PCDH9 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007267cell-cell signaling-IBA21873635  
GO:0030900forebrain development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030426growth cone-IEA-  
GO:0044291cell-cell contact zone-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal