Gene: GLRX2

51022
CGI-133|GRX2
glutaredoxin 2
protein-coding
1q31.2
Ensembl:ENSG00000023572 MIM:606820 Vega:OTTHUMG00000035677 UniprotKB:Q9NS18
NG_029745.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.727e-1 (AD)  3.170e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KHDRBS30.884
MCTS10.879
ATP6V1D0.878
MTX20.875
VDAC30.874
NKIRAS10.873
UBE2T0.873
C3orf140.871
RNF80.87
STMN20.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.506
SLC2A4-0.472
OR4F29-0.472
ASB4-0.471
PARD3B-0.468
IL18RAP-0.446
RREB1-0.428
MAGEA12-0.414
RGS22-0.412
PON3-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of GLRX2 mRNA"20453058
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GLRX2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GLRX2 mRNA"24378064
C4171904-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine"4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine results in increased expression of GLRX2 mRNA"19768707
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C038491allyl sulfideallyl sulfide results in increased expression of GLRX2 mRNA19768707
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLRX2 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of GLRX2 mRNA19371625
C006780bisphenol Abisphenol A affects the expression of GLRX2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GLRX2 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of GLRX2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of GLRX2 mRNA25979313
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of GLRX2 mRNA24690739
D002945CisplatinCisplatin results in decreased expression of GLRX2 mRNA27392435
D002945CisplatinGLRX2 protein affects the susceptibility to Cisplatin16217747
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of GLRX2 mRNA24690739
D004237DiuronDiuron results in increased expression of GLRX2 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLRX2 mRNA22079256
D015025ZearalenoneZearalenone results in increased expression of GLRX2 mRNA19371625
D018120FinasterideFinasteride results in increased expression of GLRX2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of GLRX2 mRNA24136188
D019833GenisteinGenistein results in increased expression of GLRX2 mRNA19371625
D007213IndomethacinIndomethacin results in increased expression of GLRX2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GLRX2 mRNA25613284
C410337K 7174K 7174 results in increased expression of GLRX2 mRNA24086573
C042720mercuric bromidemercuric bromide results in increased expression of GLRX2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
D008751Methylene Blue[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA24556215
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GLRX2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GLRX2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GLRX2 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of GLRX2 mRNA23360888
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GLRX2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GLRX2 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of GLRX2 mRNA24136188
C012655nimesulidenimesulide results in increased expression of GLRX2 mRNA24136188
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GLRX2 mRNA26272509
D010269ParaquatParaquat results in decreased expression of GLRX2 mRNA12732627
D010269ParaquatParaquat results in increased expression of GLRX2 mRNA21371552
D010634PhenobarbitalPhenobarbital results in decreased expression of GLRX2 mRNA19768707
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GLRX2 mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of GLRX2 mRNA22538082
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLRX2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GLRX2 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLRX2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GLRX2 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of GLRX2 mRNA21632981
C059514resveratrolresveratrol results in increased expression of GLRX2 mRNA19371625
D015474IsotretinoinIsotretinoin results in decreased expression of GLRX2 mRNA20436886
D012643SeleniumSelenium affects the activity of GLRX2 protein19351701
D012643SeleniumSelenium affects the expression of GLRX2 protein19351701
C074269Sunphenon"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GLRX2 mRNA"24378064
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLRX2 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLRX2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GLRX2 mRNA25613284
D013893ThiramThiram results in increased expression of GLRX2 mRNA20530235
D014050TolueneToluene affects the expression of GLRX2 mRNA21827849
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GLRX2 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GLRX2 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GLRX2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GLRX2 mRNA23179753|2438349
C025643vinclozolinvinclozolin affects the expression of GLRX2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003756protein disulfide isomerase activity-TAS11297543  11397793  
GO:0008794arsenate reductase (glutaredoxin) activity-TAS11297543  11397793  
GO:0009055electron transfer activity-NAS11297543  
GO:0015035protein disulfide oxidoreductase activity-IEA-  
GO:0015038glutathione disulfide oxidoreductase activity-TAS11297543  11397793  
GO:0046872metal ion binding-IEA-  
GO:00515372 iron, 2 sulfur cluster binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-NAS11297543  
GO:0006749glutathione metabolic process-TAS11397793  
GO:0006915apoptotic process-NAS11297543  
GO:0007568aging-IEA-  
GO:0009266response to temperature stimulus-NAS11397793  
GO:0009966regulation of signal transduction-NAS11297543  
GO:0010033response to organic substance-IDA11397793  
GO:0022900electron transport chain-IEA-  
GO:0030154cell differentiation-NAS11297543  
GO:0042262DNA protection-NAS11297543  11397793  
GO:0042542response to hydrogen peroxide-IDA11397793  
GO:0045454cell redox homeostasis-TAS11397793  
GO:0051775response to redox state-TAS11297543  
GO:0071451cellular response to superoxide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11297543  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA11297543  11397793  
GO:0005759mitochondrial matrix-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23688726Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)Tang WFree Radic Biol Med
21715529Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. (2011 Sep)O'Shaughnessy PJJ Clin Endocrinol Metab