Gene info: ID 51024

Gene: FIS1

GENE ID: 51024

Synonyms: CGI-135|TTC11

Description: fission, mitochondrial 1

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000214253 MIM:609003 Vega:OTTHUMG00000157106 UniprotKB:Q9Y3D6

RefSeq: NC_000007.14

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.115e-1 (AD) 6.387e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17944572	chr7:100888748	FIS1		8.860e-8	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
POLR2I	0.962
LAMTOR4	0.946
NDUFA13	0.945
TBCB	0.939
RNF5	0.933
UQCR11	0.932
COX4I1	0.932
MRPL51	0.928
TCEAL3	0.925
NDUFB7	0.924

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.802
OR4F5	-0.786
CCDC36	-0.259
MTRNR2L6	-0.234
DNAH11	-0.23
C9orf84	-0.225
SIX1	-0.214
KCNJ15	-0.211
PZP	-0.211
SULT1C2	-0.208

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of FIS1 mRNA"	19162173
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 results in decreased expression of FIS1 protein	20678484
C477819	15-deoxyprostaglandin J2	quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [15-deoxyprostaglandin J2 results in decreased expression of FIS1 protein]	20678484
C042375	4-diphenylacetoxy-1,1-dimethylpiperidinium	"4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased expression of FIS1 protein"	27491814
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased expression of FIS1 protein"	27491814
D000082	Acetaminophen	Acetaminophen results in decreased expression of FIS1 mRNA	25704631
D001280	Atrazine	Atrazine results in decreased expression of FIS1 mRNA	22378314
C006780	bisphenol A	bisphenol A results in decreased methylation of FIS1 promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of FIS1 mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in increased expression of FIS1 protein	28903499
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of FIS1 mRNA	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of FIS1 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FIS1 mRNA	18804290
D002118	Calcium	Calcium affects the expression of FIS1 mRNA	15913539
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of FIS1 mRNA	23650126
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FIS1 mRNA	19376846
D003474	Curcumin	Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein]	28698153
D003571	Cytochalasin B	Cytochalasin B results in increased expression of FIS1 protein	26732598
D003976	Diazinon	Diazinon affects the expression of FIS1 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of FIS1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of FIS1 protein	28698153
D002945	Cisplatin	Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein]	28698153
D004026	Dieldrin	Dieldrin affects the expression of FIS1 mRNA	22546817
D004237	Diuron	Diuron results in decreased expression of FIS1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin affects the expression of FIS1 protein	29385562
C062669	epicatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
C062669	epicatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]	29061316
C045651	epigallocatechin gallate	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
C045651	epigallocatechin gallate	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]	29061316
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FIS1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FIS1 mRNA	17942748
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of FIS1 mRNA	28189721
D005459	Fluorides	Fluorides results in increased expression of FIS1 mRNA	23007560
D005459	Fluorides	Fluorides results in increased expression of FIS1 protein	23007560
D005485	Flutamide	Flutamide results in decreased expression of FIS1 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of FIS1 mRNA	24136188
D005707	Gallic Acid	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
D005707	Gallic Acid	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]	29061316
C057580	gallocatechol	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
C057580	gallocatechol	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]	29061316
D005897	Glafenine	Glafenine results in increased expression of FIS1 mRNA	24136188
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of FIS1 mRNA	17183730
D006861	Hydrogen Peroxide	ARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]	29061316
D006861	Hydrogen Peroxide	[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]	29061316
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of FIS1 protein	29061316
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FIS1 mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in increased expression of FIS1 protein	27491814
D048628	Ketolides	Ketolides analog results in increased expression of FIS1 mRNA	24967691
D007657	Ketone Bodies	Ketone Bodies results in increased expression of FIS1 mRNA	16807920
D016685	Mitomycin	FIS1 protein affects the susceptibility to Mitomycin	16217747
C022838	nickel chloride	nickel chloride affects the expression of FIS1 mRNA	22546817
D015739	Nocodazole	Nocodazole results in increased expression of FIS1 protein	26732598
D019319	Okadaic Acid	Okadaic Acid results in increased expression of FIS1 protein	26732598
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of FIS1 mRNA]"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of FIS1 mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of FIS1 mRNA]"	21673326
D017239	Paclitaxel	Paclitaxel results in increased expression of FIS1 protein	26732598
D052638	Particulate Matter	Particulate Matter results in increased expression of FIS1 protein	25560372
D010634	Phenobarbital	Phenobarbital affects the expression of FIS1 mRNA	19159669
D010695	Phlorhizin	Phlorhizin results in increased expression of FIS1 mRNA	22538082
C468548	quinoline-val-asp(OMe)-CH2-OPH	quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [15-deoxyprostaglandin J2 results in decreased expression of FIS1 protein]	20678484
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of FIS1 mRNA	16079270
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of FIS1 mRNA	15576828
C059514	resveratrol	resveratrol results in increased expression of FIS1 mRNA	21224254
C059514	resveratrol	resveratrol results in increased expression of FIS1 mRNA	21224254
C059514	resveratrol	resveratrol inhibits the reaction [Rotenone results in decreased expression of FIS1 mRNA]	26770656
C059514	resveratrol	resveratrol inhibits the reaction [Rotenone results in decreased expression of FIS1 protein]	26770656
D012402	Rotenone	Rotenone results in decreased expression of FIS1 mRNA	23186747
D012402	Rotenone	resveratrol inhibits the reaction [Rotenone results in decreased expression of FIS1 mRNA]	26770656
D012402	Rotenone	resveratrol inhibits the reaction [Rotenone results in decreased expression of FIS1 protein]	26770656
D012402	Rotenone	Rotenone results in decreased expression of FIS1 mRNA	26770656
D012402	Rotenone	Rotenone results in decreased expression of FIS1 protein	26770656
D012643	Selenium	Selenium results in increased expression of FIS1 mRNA	19244175
C016766	sulforafan	sulforafan results in increased expression of FIS1 protein	27993529
C016766	sulforafan	sulforafan results in decreased expression of FIS1 protein	27993529
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FIS1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FIS1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FIS1 mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FIS1 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FIS1 mRNA	27255386
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of FIS1 mRNA	19448997
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of FIS1 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of FIS1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FIS1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of FIS1 gene	29154799
C025643	vinclozolin	vinclozolin affects the expression of FIS1 mRNA	23034163
D014810	Vitamin E	Vitamin E results in increased expression of FIS1 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	IPI	20178365
GO:0005515	protein binding	-	IPI	12861026 16874301 17408615 18782765 20826455 21149567 21183955 21699783 21701560 25416956
GO:0044877	protein-containing complex binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000266	mitochondrial fission	-	IBA	21873635
GO:0000266	mitochondrial fission	-	IDA	16118244 18845145
GO:0000266	mitochondrial fission	-	IMP	19864424
GO:0000422	autophagy of mitochondrion	-	IBA	21873635
GO:0000422	autophagy of mitochondrion	-	IDA	18515060
GO:0001836	release of cytochrome c from mitochondria	-	IMP	19864424
GO:0006626	protein targeting to mitochondrion	-	IMP	18845145
GO:0006915	apoptotic process	-	IBA	21873635
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IMP	21183955
GO:0008053	mitochondrial fusion	-	IMP	23921378
GO:0010821	regulation of mitochondrion organization	-	IMP	18353969 21149567
GO:0014850	response to muscle activity	-	IEA	-
GO:0016559	peroxisome fission	-	IBA	21873635
GO:0016559	peroxisome fission	-	IDA	16107562 17408615
GO:0016559	peroxisome fission	-	IMP	20826455
GO:0031667	response to nutrient levels	-	IEA	-
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	-	IMP	21183955
GO:0035584	calcium-mediated signaling using intracellular calcium source	-	IMP	21183955
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IMP	21183955
GO:0043525	positive regulation of neuron apoptotic process	-	IEA	-
GO:0043653	mitochondrial fragmentation involved in apoptotic process	-	IBA	21873635
GO:0043653	mitochondrial fragmentation involved in apoptotic process	-	IDA	16118244 17545159
GO:0043653	mitochondrial fragmentation involved in apoptotic process	-	IMP	18353969 19864424
GO:0051260	protein homooligomerization	-	IMP	18845145
GO:0051561	positive regulation of mitochondrial calcium ion concentration	-	IMP	21183955
GO:0070584	mitochondrion morphogenesis	-	IMP	18845145 21149567
GO:0071333	cellular response to glucose stimulus	-	IEA	-
GO:0090141	positive regulation of mitochondrial fission	-	IDA	23283981
GO:0090314	positive regulation of protein targeting to membrane	-	IDA	23283981
GO:0097237	cellular response to toxic substance	-	IEA	-
GO:1901653	cellular response to peptide	-	IEA	-
GO:1902617	response to fluoride	-	IEA	-
GO:1904579	cellular response to thapsigargin	-	IEA	-
GO:1905395	response to flavonoid	-	IEA	-
GO:1990910	response to hypobaric hypoxia	-	IEA	-
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	-	IMP	21183955

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	17408615 17545159 18782765 19864424 20451243 21183955
GO:0005741	mitochondrial outer membrane	-	IBA	21873635
GO:0005777	peroxisome	-	IBA	21873635
GO:0005777	peroxisome	-	IDA	18782765 20451243 23921378
GO:0005777	peroxisome	-	ISS	14561759
GO:0005779	integral component of peroxisomal membrane	-	IBA	21873635
GO:0005779	integral component of peroxisomal membrane	-	IDA	16107562 17408615
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0031307	integral component of mitochondrial outer membrane	-	IBA	21873635
GO:0031307	integral component of mitochondrial outer membrane	-	IDA	14996942
GO:0031307	integral component of mitochondrial outer membrane	-	NAS	18845145
GO:0032991	protein-containing complex	-	IDA	17408615 20826455

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24088173	Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. (2013 Oct 2)	Hoffmann RF	Respir Res