Gene: PI15

51050
CRISP8|P24TI|P25TI
peptidase inhibitor 15
protein-coding
8q21.13
Ensembl:ENSG00000137558 MIM:607076 Vega:OTTHUMG00000164528 UniprotKB:O43692
NC_000008.11
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.538e-1 (AD)  9.962e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALX30.86
TRPC40.799
ALPK10.792
TLR100.784
ANKRD220.754
SLC16A120.75
PROS10.745
SRPX20.744
FCGR2C0.743
C70.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.485
NOG-0.469
C1orf53-0.458
KCNIP3-0.446
C9orf24-0.446
HHATL-0.424
CPLX3-0.422
C15orf59-0.421
ARSF-0.413
WNT7A-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PI15 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of PI15 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PI15 gene27153756
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PI15 mRNA20660070
C006780bisphenol Abisphenol A affects the expression of PI15 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PI15 promoter22457795
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PI15 mRNA28962523
D004397FonofosFonofos results in increased methylation of PI15 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of PI15 mRNA19167457
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of PI15 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PI15 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PI15 mRNA"25554681
D009532NickelNickel results in increased expression of PI15 mRNA25583101
D010278ParathionParathion results in increased methylation of PI15 promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PI15 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of PI15 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of PI15 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PI15 mRNA20660070
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PI15 mRNA27029645
C012568terbufosterbufos results in increased methylation of PI15 promoter22847954
C012589trichostatin Atrichostatin A results in decreased expression of PI15 mRNA26705709
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PI15 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PI15 mRNA26272509|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PI15 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030414peptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0008150biological_process-ND-  
GO:0010466negative regulation of peptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics
24766722Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study. (2014 Apr 27)Kim VRespir Res
25248436Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. (2014 Aug 8)Kim VRespir Res