Gene: PLEKHA8P1

51054
PLEKHA9
pleckstrin homology domain containing A8 pseudogene 1
pseudo
12q12
Ensembl:ENSG00000134297 UniprotKB:O95397
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.122e-1 (AD)  8.123e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12231753chr12:45203757 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SULF10.639
CCT50.636
TYW30.635
STARD130.633
GNPNAT10.632
NOP140.63
ZNF37A0.627
TMPO0.625
SSTR20.625
SYNPO20.624

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PON1-0.485
EYA1-0.44
ALDH1L1-AS2-0.426
PON3-0.414
ENDOU-0.409
TLCD1-0.399
NPFFR1-0.396
HKDC1-0.396
HPDL-0.394
MMP28-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in decreased expression of PLEKHA8P1 mRNA22378314
C045463leflunomideleflunomide results in decreased expression of PLEKHA8P1 mRNA28988120
D019284ThapsigarginThapsigargin results in decreased expression of PLEKHA8P1 mRNA22378314
D014415TunicamycinTunicamycin results in decreased expression of PLEKHA8P1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PLEKHA8P1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLEKHA8P1 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IBA21873635  
GO:0120013intermembrane lipid transfer activity-IEA-  
GO:1902387ceramide 1-phosphate binding-IBA21873635  
GO:1902388ceramide 1-phosphate transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0035621ER to Golgi ceramide transport-IBA21873635  
GO:0035627ceramide transport-IBA21873635  
GO:0120009intermembrane lipid transfer-IBA21873635  
GO:0120009intermembrane lipid transfer-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0016020membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal