Gene: PCK2

5106
PEPCK|PEPCK-M|PEPCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
protein-coding
14q11.2-q12
Ensembl:ENSG00000100889 MIM:614095 Vega:OTTHUMG00000028791 UniprotKB:Q16822
NG_008162.2
PubMed
0   ANCO-SNPs
AD
1   
3.495e-1 (AD)  5.333e-1 (ND)   (Frontal_Cortex)
3.287e-1 (AD)  2.733e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DHRSX0.735
PLEKHO20.724
RAB340.715
NECAP20.713
TGIF20.711
LAP30.709
PLTP0.705
ARHGEF400.702
SCARA30.699
NXT20.695

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNK9-0.375
TRPV6-0.37
LHFPL5-0.364
ISLR2-0.363
CALHM1-0.359
GALNT14-0.354
ADTRP-0.354
KCNB2-0.351
CIDEA-0.351
B3GALT2-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of PCK2 mRNA19041380
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of PCK2 mRNA"19095052
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PCK2 mRNA"19167446
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of PCK2 mRNA"19561079
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of PCK2 mRNA26382854
C0293704-toluidine4-toluidine results in increased expression of PCK2 mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of PCK2 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of PCK2 mRNA17562736
C056165acetovanilloneacetovanillone inhibits the reaction [Alloxan results in increased activity of PCK2 protein]20934416
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PCK2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PCK2 mRNA21632981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PCK2 mRNA19770486
D000496Alloxanacetovanillone inhibits the reaction [Alloxan results in increased activity of PCK2 protein]20934416
D000496AlloxanAlloxan results in increased activity of PCK2 protein20934416
D000638AmiodaroneAmiodarone results in increased expression of PCK2 mRNA24489787
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PCK2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PCK2 protein19364129
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PCK2 mRNA"19446018
D001205Ascorbic AcidAscorbic Acid results in decreased expression of PCK2 mRNA19197388
D001280AtrazineAtrazine results in decreased expression of PCK2 mRNA27114639
D001280AtrazineAtrazine results in increased expression of PCK2 mRNA22378314
D001280AtrazineAtrazine results in increased expression of PCK2 mRNA27114639
C547126AZM551248AZM551248 results in increased expression of PCK2 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of PCK2 mRNA23656298
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of PCK2 mRNA17690111
C041512benzo(b)fluorene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in decreased expression of PCK2 mRNA22120849
D053119Benzophenanthridines[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in decreased expression of PCK2 mRNA22120849
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of PCK2 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCK2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCK2 mRNA19770486
D004958EstradiolEstradiol results in increased expression of PCK2 mRNA15757668
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PCK2 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of PCK2 mRNA28946120
C006780bisphenol Abisphenol A results in increased expression of PCK2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PCK2 mRNA25270620
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PCK2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PCK2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of PCK2 mRNA25270620
C584509C646 compoundC646 compound results in increased expression of PCK2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PCK2 mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of PCK2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PCK2 mRNA17484886
D002392CatechinCatechin inhibits the reaction [Glucose results in increased expression of PCK2 protein]24262486
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PCK2 mRNA20938992
D002994ClofibrateClofibrate results in increased expression of PCK2 protein19952500
D002995Clofibric AcidClofibric Acid affects the expression of PCK2 mRNA17602206
D003300Copper[Disulfiram binds to Copper] which results in increased expression of PCK2 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PCK2 mRNA20971185
D019327Copper SulfateCopper Sulfate affects the expression of PCK2 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of PCK2 mRNA15755911
C030123coumarincoumarin results in increased expression of PCK2 mRNA18480146
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PCK2 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of PCK2 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of PCK2 mRNA24650576
D016572CyclosporineCyclosporine affects the expression of PCK2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PCK2 mRNA21632981|2214713
D000069439DasatinibDasatinib results in increased expression of PCK2 mRNA20579391
C014347decitabinedecitabine affects the expression of PCK2 mRNA23300844
D013759DronabinolDronabinol results in increased expression of PCK2 mRNA16616335
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PCK2 mRNA28973377
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PCK2 mRNA21266533
D002945CisplatinCisplatin affects the expression of PCK2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PCK2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PCK2 mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PCK2 mRNA26924002
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA15784690
D004041Dietary FatsDietary Fats promotes the reaction [imidacloprid results in increased expression of PCK2 mRNA]27960282
D004041Dietary FatsDietary Fats results in increased expression of PCK2 mRNA25016146|2796028
D004041Dietary Fatsimidacloprid promotes the reaction [Dietary Fats results in increased expression of PCK2 mRNA]27960282
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PCK2 mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PCK2 mRNA24535843
C024629dimethyl phthalatedimethyl phthalate results in increased expression of PCK2 mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of PCK2 mRNA24690739
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCK2 mRNA26159488
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PCK2 mRNA17555576
D005047EtoposideEtoposide results in decreased expression of PCK2 mRNA25270620
D015025ZearalenoneZearalenone results in increased expression of PCK2 protein25058043
C540355fenamidonefenamidone results in increased expression of PCK2 mRNA27029645
D011345FenofibrateFenofibrate results in increased expression of PCK2 mRNA16569247
C061365flusilazoleflusilazole results in decreased expression of PCK2 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of PCK2 mRNA22382673
D005485FlutamideFlutamide results in decreased expression of PCK2 mRNA24793618
D005485FlutamideFlutamide results in increased expression of PCK2 mRNA21525395|2413618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PCK2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of PCK2 mRNA27664576
D019833GenisteinGenistein results in increased expression of PCK2 mRNA15757668|2686566
D005839GentamicinsGentamicins results in decreased expression of PCK2 mRNA22061828
D005897GlafenineGlafenine results in increased expression of PCK2 mRNA24136188
D005947GlucoseCatechin inhibits the reaction [Glucose results in increased expression of PCK2 protein]24262486
D005947GlucoseGlucose results in increased expression of PCK2 protein24262486
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in increased expression of PCK2 protein]24262486
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PCK2 mRNA22634610
C492448ICG 001ICG 001 results in increased expression of PCK2 mRNA26191083
C082359imidaclopridDietary Fats promotes the reaction [imidacloprid results in increased expression of PCK2 mRNA]27960282
C082359imidaclopridimidacloprid promotes the reaction [Dietary Fats results in increased expression of PCK2 mRNA]27960282
C082359imidaclopridimidacloprid results in increased expression of PCK2 mRNA27960282
D007213IndomethacinIndomethacin results in decreased expression of PCK2 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PCK2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of PCK2 mRNA27392435
C008261lead acetatelead acetate results in increased expression of PCK2 mRNA25270620
D008345ManganeseManganese binds to PCK2 protein16819824
D008345ManganeseManganese binds to [PCK2 protein binds to Phosphoenolpyruvate]16819824
D008701MethapyrileneMethapyrilene results in increased expression of PCK2 mRNA22484513
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PCK2 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PCK2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PCK2 promoter"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PCK2 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PCK2 mRNA26924002
C523799MRK 003PCK2 results in decreased susceptibility to MRK 00319903844
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PCK2 mRNA19812364
D009532NickelNickel results in decreased expression of PCK2 mRNA24084258
C028007nickel monoxidenickel monoxide results in increased expression of PCK2 mRNA19167457
C025256nonylphenolnonylphenol results in increased expression of PCK2 mRNA26382854
C570897NSC668394NSC668394 results in increased expression of PCK2 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PCK2 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of PCK2 mRNA19287073
C030110oxaliplatinoxaliplatin results in decreased expression of PCK2 mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PCK2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PCK2 mRNA25729387
D062907Oxaloacetic AcidPCK2 protein results in decreased carboxylation of Oxaloacetic Acid16819824
D010100OxygenOxygen deficiency results in increased expression of PCK2 mRNA18258771
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PCK2 mRNA26705709
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of PCK2 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PCK2 mRNA21723365
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PCK2 mRNA21723365
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PCK2 mRNA21723365
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PCK2 mRNA17097637
D010578PetroleumPetroleum affects the expression of PCK2 mRNA25208076
D010728PhosphoenolpyruvateManganese binds to [PCK2 protein binds to Phosphoenolpyruvate]16819824
D010728PhosphoenolpyruvatePCK2 protein results in increased chemical synthesis of Phosphoenolpyruvate16819824
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in increased expression of PCK2 protein]24262486
D011374ProgesteroneProgesterone results in decreased expression of PCK2 mRNA23012394|2301818
D011374ProgesteroneProgesterone results in increased expression of PCK2 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in increased expression of PCK2 mRNA24780913
C059514resveratrolresveratrol results in increased expression of PCK2 protein25505154
C447880retene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in decreased expression of PCK2 mRNA22120849
C089730rosiglitazonerosiglitazone results in decreased expression of PCK2 mRNA25572481
C089730rosiglitazonerosiglitazone affects the expression of PCK2 protein21347706
D012645SelenomethionineSelenomethionine affects the expression of PCK2 mRNA17222674
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PCK2 mRNA23806026
D012834SilverSilver analog results in increased expression of PCK2 mRNA24974767
D012834SilverSilver analog results in increased expression of PCK2 mRNA22727896
D012835Silver NitrateSilver Nitrate results in decreased expression of PCK2 mRNA22727896
C009277sodium arsenatesodium arsenate results in decreased expression of PCK2 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of PCK2 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of PCK2 protein24866292
C017947sodium arsenitesodium arsenite results in decreased expression of PCK2 protein24866292
C016104sodium bichromatesodium bichromate results in decreased expression of PCK2 mRNA24612858
D012969Sodium FluorideSodium Fluoride results in decreased expression of PCK2 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of PCK2 mRNA24383545
D013467SulindacSulindac results in increased expression of PCK2 mRNA11906190
D013629TamoxifenTamoxifen affects the expression of PCK2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCK2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCK2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCK2 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PCK2 mRNA28973375
D019284ThapsigarginThapsigargin results in decreased expression of PCK2 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of PCK2 mRNA21694771|2237831
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PCK2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PCK2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PCK2 protein15894607
D014303TrinitrotolueneTrinitrotoluene affects the expression of PCK2 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PCK2 mRNA"23919627
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PCK2 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of PCK2 mRNA25572481
C057693troglitazonetroglitazone results in increased expression of PCK2 mRNA20846491
D014415TunicamycinTunicamycin results in decreased expression of PCK2 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of PCK2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of PCK2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PCK2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCK2 mRNA24489787
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PCK2 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of PCK2 mRNA"25208076
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004611phosphoenolpyruvate carboxykinase activity-TAS8645161  
GO:0004613phosphoenolpyruvate carboxykinase (GTP) activity-IBA21873635  
GO:0004613phosphoenolpyruvate carboxykinase (GTP) activity-TAS-  
GO:0005515protein binding-IPI21988832  
GO:0005525GTP binding-IEA-  
GO:0030145manganese ion binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006090pyruvate metabolic process-IBA21873635  
GO:0006090pyruvate metabolic process-IEA-  
GO:0006094gluconeogenesis-IBA21873635  
GO:0006094gluconeogenesis-IEA-  
GO:0006094gluconeogenesis-TAS-  
GO:0006107oxaloacetate metabolic process-IEA-  
GO:0006116NADH oxidation-IEA-  
GO:0006807nitrogen compound metabolic process-IBA21873635  
GO:0019543propionate catabolic process-IBA21873635  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032869cellular response to insulin stimulus-IBA21873635  
GO:0033993response to lipid-IBA21873635  
GO:0042594response to starvation-IBA21873635  
GO:0046327glycerol biosynthetic process from pyruvate-IBA21873635  
GO:0070365hepatocyte differentiation-IBA21873635  
GO:0071333cellular response to glucose stimulus-IBA21873635  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071548response to dexamethasone-IEA-  
GO:0071549cellular response to dexamethasone stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosolNOTIBA21873635  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00020Citrate cycle (TCA cycle)
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04964Proximal tubule bicarbonate reclamation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26321514Upregulated hepatic expression of mitochondrial PEPCK triggers initial gluconeogenic reactions in the HCV-3 patients. (2015 Aug)Sheikh TIAsian Pac J Trop Med