Gene: DERA

51071
CGI-26|DEOC
deoxyribose-phosphate aldolase
protein-coding
12p12.3
Ensembl:ENSG00000023697 Vega:OTTHUMG00000165537 UniprotKB:Q9Y315
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.408e-1 (AD)  2.700e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYPL10.884
NPC20.88
MAPRE10.867
VAMP30.85
MAGT10.848
CPQ0.848
TMBIM40.848
SEC11A0.845
C1orf1980.844
GINM10.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPRD1-0.531
ABCC12-0.518
ADRA1D-0.513
FBLN7-0.5
CALHM1-0.495
MARCH4-0.489
KCNB2-0.487
GRIN2B-0.481
HTR6-0.476
KCNG1-0.475

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DERA mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DERA mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of DERA mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DERA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DERA mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DERA mRNA22228805
D004958EstradiolEstradiol results in increased expression of DERA mRNA19167446
C004541biochanin Abiochanin A results in decreased expression of DERA mRNA12111696
C006780bisphenol Abisphenol A affects the expression of DERA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DERA mRNA25047013
C006780bisphenol Abisphenol A affects the expression of DERA mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of DERA mRNA19320972
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DERA mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DERA mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DERA mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of DERA mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of DERA mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DERA mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of DERA mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DERA mRNA21266533
D002945CisplatinCisplatin results in increased expression of DERA mRNA27392435|2759478
C000944dicrotophosdicrotophos results in decreased expression of DERA mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of DERA mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of DERA mRNA"22485181
D004237DiuronDiuron results in increased expression of DERA mRNA21551480
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DERA mRNA23649840
D005897GlafenineGlafenine results in decreased expression of DERA mRNA24136188
D007213IndomethacinIndomethacin results in increased expression of DERA mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DERA mRNA25613284
C045463leflunomideleflunomide results in decreased expression of DERA mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DERA mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DERA mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DERA mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DERA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DERA mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of DERA mRNA18978301
C025256nonylphenolnonylphenol results in increased expression of DERA mRNA22982499
D010634PhenobarbitalPhenobarbital affects the expression of DERA mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of DERA mRNA23557933
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DERA mRNA19167446
D012643SeleniumSelenium results in decreased expression of DERA mRNA19244175
C017947sodium arsenitesodium arsenite affects the expression of DERA mRNA29319823
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DERA mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DERA mRNA19042947
D014520UrethaneUrethane results in decreased expression of DERA mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DERA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DERA gene29154799
D014638VanadatesVanadates results in increased expression of DERA mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DERA gene25560391
D014747VinblastineDERA protein affects the susceptibility to Vinblastine16217747

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004139deoxyribose-phosphate aldolase activity-IBA21873635  
GO:0004139deoxyribose-phosphate aldolase activity-IDA9226884  
GO:0004139deoxyribose-phosphate aldolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006098pentose-phosphate shunt-TAS-  
GO:0009264deoxyribonucleotide catabolic process-IBA21873635  
GO:0016052carbohydrate catabolic process-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0046121deoxyribonucleoside catabolic process-IDA9226884  
GO:0046386deoxyribose phosphate catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IDA-  
GO:0005829cytosol-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00030Pentose phosphate pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-71336Pentose phosphate pathway (hexose monophosphate shunt)TAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23079611Indoor radon monitoring near an in situ leach mining site in D G Khan, Pakistan. (2012 Dec)MatiullahJ Radiol Prot