Gene: CUTC

51076
CGI-32
cutC copper transporter
protein-coding
10q24.2
Ensembl:ENSG00000119929 MIM:610101 Vega:OTTHUMG00000018889 UniprotKB:Q9NTM9
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.026e-1 (AD)  7.115e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17112202chr10:99735234 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COMMD30.885
MTIF30.872
NPM10.867
SCCPDH0.863
EIF3H0.861
SNW10.861
TMEM590.856
MRFAP10.855
CNPY20.854
TIMM90.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.666
OR4F5-0.662
MTRNR2L6-0.275
MTRNR2L9-0.25
MTRNR2L10-0.242
RNF223-0.241
TTLL10-0.241
SDIM1-0.227
C8orf74-0.224
TAS2R41-0.22

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CUTC mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CUTC mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CUTC mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CUTC mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CUTC mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of CUTC mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CUTC mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CUTC mRNA21715664|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUTC mRNA"20382639
C038328BEP protocolBEP protocol results in decreased expression of CUTC mRNA18987330
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CUTC mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CUTC mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CUTC mRNA18804290
C018021cobaltous chloridecobaltous chloride results in decreased expression of CUTC mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of CUTC mRNA19549813|2059984
D016572CyclosporineCyclosporine results in decreased methylation of CUTC promoter27989131
D003907DexamethasoneDexamethasone results in increased expression of CUTC mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CUTC mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CUTC mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CUTC mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CUTC mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CUTC protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CUTC mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CUTC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUTC mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CUTC mRNA23649840
D005472FluorouracilCUTC protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CUTC mRNA]15016801
D005485FlutamideFlutamide results in decreased expression of CUTC mRNA24793618
D005485FlutamideFlutamide results in increased expression of CUTC mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of CUTC mRNA23649840
C492448ICG 001ICG 001 results in decreased expression of CUTC mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CUTC mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CUTC mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CUTC mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CUTC mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CUTC mRNA24297863
C410337K 7174K 7174 results in decreased expression of CUTC mRNA24086573
C045463leflunomideleflunomide results in decreased expression of CUTC mRNA28988120
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CUTC mRNA18804290
D011374ProgesteroneProgesterone results in increased expression of CUTC mRNA20631399
D011794QuercetinQuercetin results in decreased expression of CUTC mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of CUTC mRNA19244175
D012643SeleniumSelenium results in decreased expression of CUTC mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of CUTC mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of CUTC mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of CUTC mRNA17879257
C016104sodium bichromatesodium bichromate affects the expression of CUTC mRNA22110744
D012969Sodium FluorideSodium Fluoride results in decreased expression of CUTC mRNA27862939
D013629TamoxifenTamoxifen affects the expression of CUTC mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUTC mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUTC mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CUTC mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CUTC gene27618143
C012589trichostatin Atrichostatin A affects the expression of CUTC mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of CUTC mRNA29154799
D014638VanadatesVanadates results in decreased expression of CUTC mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CUTC gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of CUTC mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of CUTC mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005507copper ion binding-IDA19878721  
GO:0005507copper ion binding-NAS16182249  
GO:0005515protein binding-IPI25416956  27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0006825copper ion transport-NAS16182249  
GO:0051262protein tetramerization-IPI19878721  
GO:0055070copper ion homeostasis-NAS16182249  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA16182249  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA16182249  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesIEA
R-HSA-936837Ion transport by P-type ATPasesIEA
R-HSA-983712Ion channel transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal