Gene: PCM1

5108
PTC4|RET/PCM-1
pericentriolar material 1
protein-coding
8p22
Ensembl:ENSG00000078674 MIM:600299 Vega:OTTHUMG00000163699 UniprotKB:Q15154
NG_027690.1
PubMed
0   ANCO-SNPs
ND
1   
1.282e-1 (AD)  3.583e-1 (ND)   (Frontal_Cortex)
3.098e-1 (AD)  2.337e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDFY30.869
RSF10.842
PHF30.841
SETX0.841
SNX190.834
SF3B10.833
SGCB0.833
UBXN70.831
SETD20.83
TRIP120.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.649
OR4F5-0.636
SPRR2B-0.196
KRTAP19-1-0.182
CLDN8-0.175
CCDC140-0.175
ZNF479-0.172
IL19-0.169
OR5B3-0.167
ACSM2B-0.164

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PCM1 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PCM1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PCM1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PCM1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PCM1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PCM1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PCM1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PCM1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PCM1 mRNA22521957
C006632arsenic trioxidePCM1 protein results in increased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of PCM1 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PCM1 gene25435355
C006780bisphenol Abisphenol A affects the expression of PCM1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PCM1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PCM1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PCM1 mRNA24982889
D003010ClorgylineClorgyline results in increased expression of PCM1 mRNA19691856
D003024ClozapineClozapine results in decreased expression of PCM1 mRNA19048012
D019327Copper SulfateCopper Sulfate results in decreased expression of PCM1 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of PCM1 mRNA17211630
D016572CyclosporineCyclosporine results in decreased expression of PCM1 mRNA25562108
D003703DemecolcineDemecolcine results in decreased expression of PCM1 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PCM1 mRNA]27941970
D003976DiazinonDiazinon affects the expression of PCM1 mRNA22546817
D002945CisplatinCisplatin results in decreased phosphorylation of PCM1 protein22006019
D004041Dietary FatsDietary Fats results in increased expression of PCM1 mRNA25016146
C118739entinostatentinostat results in decreased expression of PCM1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PCM1 protein23301498
D000431EthanolEthanol results in decreased expression of PCM1 mRNA29018328
D000431EthanolEthanol results in decreased expression of PCM1 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PCM1 mRNA18936297
D005419FlavonoidsFlavonoids results in decreased expression of PCM1 mRNA18035473
C001277geldanamycingeldanamycin results in increased expression of PCM1 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of PCM1 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PCM1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PCM1 mRNA18951874
C544151jinfukangjinfukang results in decreased expression of PCM1 mRNA27392435
D007854LeadLead affects the splicing of PCM1 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PCM1 mRNA21641980
D008627Mercuric ChlorideMercuric Chloride affects the expression of PCM1 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCM1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCM1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PCM1 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PCM1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PCM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PCM1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PCM1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of PCM1 mRNA24205000
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C046012pentanalpentanal results in decreased expression of PCM1 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PCM1 mRNA27153767
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of PCM1 mRNA17616710
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PCM1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of PCM1 mRNA18445702
D012643SeleniumSelenium results in decreased expression of PCM1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PCM1 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of PCM1 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PCM1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCM1 mRNA18691609|2157046
D019284ThapsigarginThapsigargin results in increased expression of PCM1 protein24648495
D013849ThimerosalThimerosal results in decreased expression of PCM1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PCM1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PCM1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PCM1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of PCM1 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PCM1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PCM1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCM1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PCM1 mRNA24935251|2627250
D014810Vitamin EVitamin E results in decreased expression of PCM1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PCM1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9361024  14520415  15107855  16189514  17574030  18000879  
18762586  18772192  19447967  20719959  22500027  24089205  
24397932  24550735  24816561  25074808  25416956  26297806  
26496610  26638075  28235840  28712572  
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0001764neuron migration-IEA-  
GO:0007098centrosome cycle-IMP17574030  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0022027interkinetic nuclear migration-ISS-  
GO:0031122cytoplasmic microtubule organization-IMP22797915  24816561  
GO:0034453microtubule anchoring-ISS-  
GO:0034454microtubule anchoring at centrosome-IBA21873635  
GO:0035176social behavior-IEA-  
GO:0035735intraciliary transport involved in cilium assembly-IMP24550735  
GO:0050768negative regulation of neurogenesis-ISS-  
GO:0060271cilium assembly-IMP15616553  17574030  
GO:0071539protein localization to centrosome-IBA21873635  
GO:0071539protein localization to centrosome-IMP24816561  
GO:0071539protein localization to centrosome-ISS-  
GO:0090316positive regulation of intracellular protein transport-IMP22797915  24550735  
GO:0097150neuronal stem cell population maintenance-IEA-  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:1905515non-motile cilium assembly-IMP23789104  
GO ID GO Term Qualifier Evidence PubMed
GO:0000242pericentriolar material-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA20719959  21399614  22797915  24421332  24550735  
GO:0005813centrosomecolocalizes_withIDA24648492  
GO:0005813centrosome-ISS-  
GO:0005814centriole-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0031965nuclear membrane-IDA-  
GO:0032991protein-containing complex-IDA24421332  
GO:0034451centriolar satellite-IDA15616553  17574030  20719959  24550735  
GO:0035869ciliary transition zone-IDA24415959  
GO:0036064ciliary basal body-IEA-  
GO:0045177apical part of cell-IEA-  
GO:0097730non-motile ciliumNOTIDA17574030  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29780256The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients. (2018)Cao LOnco Targets Ther