Gene: TNNI3K

51086
CARK|CCDD
TNNI3 interacting kinase
protein-coding
1p31.1
Ensembl:ENSG00000116783 MIM:613932 Vega:OTTHUMG00000171318 UniprotKB:Q59H18
NG_032939.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.461e-1 (AD)  4.072e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR190.827
ABCA100.819
ICA1L0.813
AMY2B0.811
SETDB20.801
OVGP10.798
ARMCX40.798
CAPRIN20.795
DSN10.792
ZNF5400.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MDFI-0.398
CCDC102A-0.395
LYPD1-0.383
HAS2-0.375
BCL7C-0.357
OR4F5-0.357
HMX1-0.351
AQP5-0.35
PRRX2-0.347
EVA1A-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TNNI3K mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TNNI3K gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNNI3K mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of TNNI3K mRNA25181051
D060729Coal AshCoal Ash results in increased expression of TNNI3K mRNA19000753
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of TNNI3K mRNA26033743
D003300CopperCopper deficiency results in increased expression of TNNI3K mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of TNNI3K mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TNNI3K mRNA23640034
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of TNNI3K mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of TNNI3K mRNA26033743
C039281furanfuran results in decreased expression of TNNI3K mRNA25539665
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TNNI3K mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNNI3K mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNNI3K mRNA"25554681
D010578PetroleumPetroleum affects the expression of TNNI3K mRNA25208076
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TNNI3K mRNA19710929
D011441PropylthiouracilPropylthiouracil results in increased expression of TNNI3K mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TNNI3K mRNA25895662
D012834SilverSilver results in increased expression of TNNI3K mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of TNNI3K gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of TNNI3K mRNA18175754
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of TNNI3K gene27618143
D014635Valproic AcidValproic Acid affects the expression of TNNI3K mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNNI3K mRNA23179753
C025643vinclozolinvinclozolin results in decreased expression of TNNI3K mRNA23034163
C111237vorinostatvorinostat results in decreased expression of TNNI3K mRNA27255383
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of TNNI3K mRNA"25208076
D015032ZincZinc deficiency results in increased expression of TNNI3K mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA12721663  
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005515protein binding-IPI12721663  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IPI18205602  
GO:0031013troponin I binding-IPI12721663  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002027regulation of heart rate-IGI23236294  
GO:0002027regulation of heart rate-IMP24925317  
GO:0006468protein phosphorylation-IDA12721663  
GO:0055117regulation of cardiac muscle contraction-IMP24925317  
GO:0086069bundle of His cell to Purkinje myocyte communication-IMP23236294  
GO:1903779regulation of cardiac conduction-IGI23236294  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12721663  
GO:0005737cytoplasm-IDA12721663  18205602  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29452776Women-specific risk factors for heart failure: A genetic approach. (2018 Mar)van der Kemp JMaturitas
26537541Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health. (2015 Nov 4)Young KLBMC Genet