Gene: SEPSECS

51091
LP|PCH2D|SLA|SLA/LP
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
protein-coding
4p15.2
Ensembl:ENSG00000109618 MIM:613009 Vega:OTTHUMG00000128563 UniprotKB:Q9HD40
NG_028222.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.061e-2 (AD)  1.687e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1070.844
ZKSCAN80.832
UEVLD0.826
TMEM1680.823
ATP7A0.822
CEP440.813
PRPF40A0.807
ENTPD50.805
HAUS60.8
SLC35A30.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNG1-0.413
ADRA2C-0.382
NANOS3-0.348
ASPDH-0.333
ZNF771-0.331
CHRNA2-0.328
WNT7A-0.323
OR4F5-0.317
PSPN-0.316
OR4F29-0.314

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of SEPSECS mRNA"20453058
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPSECS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPSECS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPSECS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPSECS mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SEPSECS mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of SEPSECS mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of SEPSECS mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEPSECS mRNA22228805
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SEPSECS mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of SEPSECS gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of SEPSECS mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of SEPSECS mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SEPSECS mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of SEPSECS mRNA28302478
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SEPSECS mRNA"23811387
C118739entinostatentinostat results in decreased expression of SEPSECS mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPSECS mRNA"27188386
D005897GlafenineGlafenine results in decreased expression of SEPSECS mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SEPSECS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SEPSECS mRNA28628672
C045463leflunomideleflunomide results in increased expression of SEPSECS mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SEPSECS mRNA19136613
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SEPSECS mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SEPSECS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SEPSECS mRNA23649840
D009285NaphthoquinonesNaphthoquinones results in increased expression of SEPSECS mRNA23811387
D009532NickelNickel results in increased expression of SEPSECS mRNA25583101
D010126OzoneOzone results in increased expression of SEPSECS mRNA28652203
C046012pentanalpentanal results in decreased expression of SEPSECS mRNA26079696
D010476PerfumePerfume results in increased expression of SEPSECS mRNA24768652
D011794QuercetinQuercetin results in decreased expression of SEPSECS mRNA21632981
C031389resorcinolresorcinol results in decreased expression of SEPSECS mRNA22623647
C089032rimonabantrimonabant affects the expression of SEPSECS mRNA19030233
D013849Thimerosal"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEPSECS mRNA"27188386
D013849ThimerosalThimerosal results in increased expression of SEPSECS mRNA27188386
C012589trichostatin Atrichostatin A results in increased expression of SEPSECS mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SEPSECS mRNA"26179874
D014520UrethaneUrethane results in increased expression of SEPSECS mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SEPSECS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SEPSECS mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of SEPSECS mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SEPSECS gene25560391
C111237vorinostatvorinostat results in increased expression of SEPSECS mRNA27188386
D015032ZincZinc results in decreased expression of SEPSECS mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-ISS-  
GO:0005515protein binding-IPI22190034  
GO:0098621phosphoseryl-selenocysteinyl-tRNA selenium transferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001514selenocysteine incorporation-ISS-  
GO:0016259selenocysteine metabolic process-TAS-  
GO:0097056selenocysteinyl-tRNA(Sec) biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00450Selenocompound metabolism
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2408522Selenoamino acid metabolismTAS
R-HSA-2408557Selenocysteine synthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal