Gene: ADIPOR1

51094
ACDCR1|CGI-45|CGI45|PAQR1|TESBP1A
adiponectin receptor 1
protein-coding
1q32.1
Ensembl:ENSG00000159346 MIM:607945 Vega:OTTHUMG00000041391 UniprotKB:Q96A54
NG_052860.1
PubMed
0   ANCO-SNPs
ND
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.214e-1 (AD)  1.281e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB100.946
CAP10.936
HNRNPK0.935
RAB7A0.933
PCBP20.931
CANX0.928
HNRNPA2B10.928
USP390.926
TMEM50A0.925
RAF10.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.867
OR4F29-0.844
HMHB1-0.169
OR6C74-0.152
CETP-0.136
MTRNR2L6-0.134
IFNG-0.132
LYZL2-0.127
FCRL1-0.126
TCL1A-0.123

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR1 protein"28284726
C00799725-hydroxycholesterol[25-hydroxycholesterol co-treated with alitretinoin] results in decreased expression of ADIPOR1 mRNA16023994
C00799725-hydroxycholesterol25-hydroxycholesterol results in decreased expression of ADIPOR1 mRNA16023994
D000082AcetaminophenADIPOR1 gene polymorphism affects the susceptibility to Acetaminophen26104854
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADIPOR1 mRNA19770486
C103303alitretinoin[25-hydroxycholesterol co-treated with alitretinoin] results in decreased expression of ADIPOR1 mRNA16023994
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ADIPOR1 mRNA21298039
D006051Aurothioglucose[Dietary Fats co-treated with Aurothioglucose] results in decreased expression of ADIPOR1 protein21382165
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADIPOR1 protein28284726
D004958EstradiolEstradiol results in increased expression of ADIPOR1 protein28284726
D001629BezafibrateBezafibrate results in increased expression of ADIPOR1 mRNA16574099
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of ADIPOR1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ADIPOR1 mRNA27103539|2865753
C006780bisphenol Abisphenol A results in increased expression of ADIPOR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ADIPOR1 protein28284726
C013418bromfenacoumbromfenacoum results in decreased expression of ADIPOR1 protein28903499
D002104CadmiumCadmium results in increased expression of ADIPOR1 mRNA23369406
C503589cis-9, trans-11-conjugated linoleic acid"[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of ADIPOR1 mRNA"17408517
D002994ClofibrateClofibrate results in decreased expression of ADIPOR1 mRNA17585979
D016572CyclosporineCyclosporine affects the expression of ADIPOR1 protein28886988
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADIPOR1 mRNA21266533
D004041Dietary Fats[Dietary Fats co-treated with Aurothioglucose] results in decreased expression of ADIPOR1 protein21382165
D004041Dietary FatsDietary Fats affects the expression of ADIPOR1 mRNA20965162
D004041Dietary FatsDietary Fats affects the expression of ADIPOR1 protein20965162
D004041Dietary Fatsrosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR1 mRNA]20965162
D004041Dietary Fatsrosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR1 protein]20965162
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ADIPOR1 mRNA27103539
D000431EthanolEthanol promotes the reaction [resveratrol results in increased expression of ADIPOR1 mRNA]18755807
D000431Ethanol[rosiglitazone co-treated with Ethanol] results in increased expression of ADIPOR1 mRNA20007851
D000431EthanolADIPOR1 protein promotes the reaction [Ethanol promotes the reaction [ADIPOQ protein results in increased expression of IL10 mRNA]]20052772
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ADIPOR1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADIPOR1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADIPOR1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ADIPOR1 mRNA23649840
C006012fenofibric acidfenofibric acid results in decreased expression of ADIPOR1 protein16023994
D005557FormaldehydeFormaldehyde results in increased expression of ADIPOR1 mRNA23649840
C039281furanfuran results in increased methylation of ADIPOR1 gene22079235
D005947GlucoseFOXO1 protein inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]24413998
D005947GlucoseFOXO1 protein inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]24413998
D005947GlucoseFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]]24413998
D005947GlucoseFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]]24413998
D005947GlucoseGlucose results in decreased expression of ADIPOR1 mRNA24413998
D005947GlucoseGlucose results in decreased expression of ADIPOR1 protein24413998
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]24413998
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]24413998
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of ADIPOR1 protein28284726
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ADIPOR1 mRNA17183730
D007854LeadLead affects the expression of ADIPOR1 mRNA28903495
D008070LipopolysaccharidesADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]20861358
D008070LipopolysaccharidesADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]20861358
D008727MethotrexateMethotrexate results in increased expression of ADIPOR1 mRNA17400583
D008731MethoxychlorMethoxychlor results in decreased expression of ADIPOR1 mRNA27103539
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ADIPOR1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ADIPOR1 mRNA29191790
D019787Linoleic AcidLinoleic Acid analog results in increased expression of ADIPOR1 mRNA27939595
D010269ParaquatADIPOQ protein promotes the reaction [Paraquat results in increased expression of ADIPOR1 mRNA]25945502
D010269ParaquatADIPOQ protein promotes the reaction [Paraquat results in increased expression of ADIPOR1 protein]25945502
D010269ParaquatADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 mRNA]25945502
D010269ParaquatADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 protein]25945502
D010269ParaquatADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]]25945502
D010269ParaquatParaquat results in increased expression of ADIPOR1 mRNA25945502
D010269ParaquatParaquat results in increased expression of ADIPOR1 protein25945502
C084656paricalcitolparicalcitol results in increased expression of ADIPOR1 protein25037058
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ADIPOR1 mRNA17681415
C006253pirinixic acidpirinixic acid affects the expression of ADIPOR1 mRNA16306350
C059514resveratrolEthanol promotes the reaction [resveratrol results in increased expression of ADIPOR1 mRNA]18755807
C059514resveratrolresveratrol results in increased expression of ADIPOR1 mRNA18755807
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]]24413998
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]]24413998
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]24413998
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]24413998
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of ADIPOR1 protein]24413998
C089730rosiglitazonerosiglitazone affects the expression of ADIPOR1 mRNA15991021
C089730rosiglitazone[rosiglitazone co-treated with Ethanol] results in increased expression of ADIPOR1 mRNA20007851
C089730rosiglitazonerosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR1 mRNA]20965162
C089730rosiglitazonerosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR1 protein]20965162
D012715Sesame OilSesame Oil results in increased expression of ADIPOR1 mRNA29191790
D012999SomanSoman results in increased expression of ADIPOR1 mRNA19281266
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of ADIPOR1 protein]24413998
D013311StreptozocinStreptozocin results in decreased expression of ADIPOR1 protein17270171|2441399
D013629TamoxifenTamoxifen affects the expression of ADIPOR1 mRNA17555576
C012568terbufosADIPOR1 gene SNP affects the susceptibility to terbufos22919386
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of ADIPOR1 mRNA26496021
D013739TestosteroneTestosterone results in decreased expression of ADIPOR1 protein28284726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADIPOR1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADIPOR1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADIPOR1 mRNA17942748
C496197trans-10,cis-12-conjugated linoleic acid"[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of ADIPOR1 mRNA"17408517
C057693troglitazonetroglitazone results in decreased expression of ADIPOR1 protein16023994
D014520UrethaneUrethane results in increased expression of ADIPOR1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ADIPOR1 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of ADIPOR1 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ADIPOR1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019901protein kinase binding-IPI19233263  
GO:0042802identical protein binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0055100adiponectin binding-IDA12802337  
GO:0097003adipokinetic hormone receptor activity-IDA12802337  
GO ID GO Term Qualifier Evidence PubMed
GO:0009755hormone-mediated signaling pathway-IDA12802337  
GO:0010633negative regulation of epithelial cell migration-IMP23776679  
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP23776679  
GO:0010906regulation of glucose metabolic process-ISS-  
GO:0019216regulation of lipid metabolic process-ISS-  
GO:0019395fatty acid oxidation-IDA12802337  
GO:0030308negative regulation of cell growth-IEA-  
GO:0033210leptin-mediated signaling pathway-IEA-  
GO:0033211adiponectin-activated signaling pathway-IBA21873635  
GO:0033211adiponectin-activated signaling pathway-IDA12802337  
GO:0042304regulation of fatty acid biosynthetic process-TAS-  
GO:0042593glucose homeostasis-ISS-  
GO:0046426negative regulation of JAK-STAT cascade-IMP23776679  
GO:0046427positive regulation of JAK-STAT cascade-IEA-  
GO:0046628positive regulation of insulin receptor signaling pathway-IEA-  
GO:1901223negative regulation of NIK/NF-kappaB signaling-IMP23776679  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA19233263  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-IDA12802337  
KEGG ID KEGG Term
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityTAS
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25270251Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment. (2015 Feb)Wu XMol Biol Rep
19051043Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. (2009 Jul)Dalamaga MCancer Causes Control
26629210Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke. (2015)Han QInt J Clin Exp Med
18097620Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals. (2008 Jan)Yamada YInt J Mol Med
18424891Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies. (2007)Petridou ETOncology
27617220Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer. (2016 Sep)Mahmoudi TMeta Gene
23358237Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma. (2013 Feb)Abdul-Ghafar JTohoku J Exp Med
25760347Adiponectin in asthma: implications for phenotyping. (2015)Nigro ECurr Protein Pept Sci
16343040Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus. (2006)Meller MPhysiol Res
22087284Interactions between genetic variants in the adiponectin, adiponectin receptor 1 and environmental factors on the risk of colorectal cancer. (2011)Liu LPLoS One
22106445HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. (2012 Jan 1)Edwards TLAm J Epidemiol
27003425Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)Korytina GFBiochem Genet