Gene: PCMT1

5110
PIMT
protein-L-isoaspartate (D-aspartate) O-methyltransferase
protein-coding
6q25.1
Ensembl:ENSG00000120265 MIM:176851 Vega:OTTHUMG00000015794 UniprotKB:P22061
NG_033960.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.557e-1 (AD)  4.117e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOAP10.983
ATP6V1D0.981
OLA10.981
MDH10.981
SLC25A40.979
NDRG30.978
YWHAB0.978
PPP3CB0.978
ATP6V1B20.977
SUCLA20.977

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.603
OR4F29-0.562
CSAG1-0.446
MAGEA12-0.425
RNF135-0.409
RAI14-0.408
CXCR2-0.408
FZD10-0.406
REST-0.404
MTRNR2L10-0.402

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01752S-adenosyl-L-homocysteineSmall Molecule979-92-0ExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione affects the expression of PCMT1 mRNA"19162173
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]"24631677
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PCMT1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of PCMT1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]24631677
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 protein]24631677
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PCMT1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PCMT1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCMT1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PCMT1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PCMT1 mRNA"19446018
D001280AtrazineAtrazine results in decreased expression of PCMT1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PCMT1 mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PCMT1 mRNA21839799
C044887beta-methylcholinebeta-methylcholine affects the expression of PCMT1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PCMT1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PCMT1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PCMT1 gene28505145
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein26930160
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PCMT1 promoter22457795
C100187chloropicrinchloropicrin results in decreased expression of PCMT1 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of PCMT1 protein28596144
C018021cobaltous chloridecobaltous chloride results in decreased expression of PCMT1 protein16622835
D003471CuprizoneCuprizone results in decreased expression of PCMT1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of PCMT1 mRNA20106945
D003976DiazinonDiazinon results in increased methylation of PCMT1 gene22964155
C000944dicrotophosdicrotophos results in decreased expression of PCMT1 mRNA28302478
D004298Dopamine"1,3-dimethylthiourea inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]"24631677
D004298DopamineAcetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]24631677
D004298DopamineAcetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 protein]24631677
D004298DopamineDopamine results in decreased expression of PCMT1 mRNA24631677
D004298DopamineDopamine results in decreased expression of PCMT1 protein24631677
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PCMT1 protein23301498
D005485FlutamideFlutamide results in increased expression of PCMT1 mRNA24136188
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of PCMT1 protein26930160
D017313FenretinideFenretinide results in decreased expression of PCMT1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PCMT1 mRNA24631677
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PCMT1 mRNA25613284
D008094LithiumLithium results in increased expression of PCMT1 mRNA19949822
D008694MethamphetamineMethamphetamine results in decreased expression of PCMT1 protein19826936
D015741MetriboloneMetribolone affects the splicing of PCMT1 mRNA17010196
C051752nefazodonenefazodone results in increased expression of PCMT1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PCMT1 mRNA17616710
D019319Okadaic AcidOkadaic Acid results in decreased expression of PCMT1 protein19397276
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PCMT1 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of PCMT1 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PCMT1 mRNA19162173
D012402RotenoneRotenone results in decreased expression of PCMT1 protein24631677
D012524SarinSarin results in decreased expression of PCMT1 mRNA19522546
C080703SK&F 83959SK&F 83959 results in increased expression of PCMT1 protein25852303
D012999SomanSoman results in decreased expression of PCMT1 mRNA19281266
C061133tamibarotenetamibarotene affects the expression of PCMT1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCMT1 mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PCMT1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCMT1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PCMT1 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of PCMT1 protein"25852303
D014212TretinoinTretinoin results in decreased expression of PCMT1 mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of PCMT1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCMT1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of PCMT1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004719protein-L-isoaspartate (D-aspartate) O-methyltransferase activity-IBA21873635  
GO:0004719protein-L-isoaspartate (D-aspartate) O-methyltransferase activity-TAS8074695  
GO:0005515protein binding-IPI17353931  20562859  25416956  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006479protein methylation-TAS3355545  
GO:0030091protein repair-TAS8074695  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5676934Protein repairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29212247A six-mRNA signature model for the prognosis of head and neck squamous cell carcinoma. (2017 Nov 7)Guo WOncotarget