Gene: PHF20L1

51105
CGI-72|TDRD20B|URLC1
PHD finger protein 20 like 1
protein-coding
8q24.22
Ensembl:ENSG00000129292 Vega:OTTHUMG00000148656 UniprotKB:A8MW92
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.772e-1 (AD)  2.504e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10956683chr8:132819238 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNT20.936
ZNF6550.932
TAF20.932
AGFG10.928
USO10.927
SMARCAD10.926
TPP20.926
RPS6KB10.925
NUP1530.925
TRAPPC80.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.568
OR4F29-0.539
S100A1-0.308
MTRNR2L10-0.247
MTRNR2L6-0.245
CSAG1-0.241
S100A14-0.237
MTRNR2L9-0.232
KLRC2-0.229
HMX1-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHF20L1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHF20L1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHF20L1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHF20L1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHF20L1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHF20L1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PHF20L1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PHF20L1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHF20L1 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of PHF20L1 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PHF20L1 mRNA24449571
D001151ArsenicArsenic affects the methylation of PHF20L1 gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PHF20L1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHF20L1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of PHF20L1 mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of PHF20L1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHF20L1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PHF20L1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHF20L1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PHF20L1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PHF20L1 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PHF20L1 mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PHF20L1 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of PHF20L1 mRNA23125180
C031180chrysenechrysene results in decreased expression of PHF20L1 mRNA26377693
D003033Coal TarCoal Tar results in decreased expression of PHF20L1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHF20L1 mRNA24386269
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PHF20L1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of PHF20L1 mRNA19167446
D013759DronabinolDronabinol results in increased expression of PHF20L1 mRNA16616335
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHF20L1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHF20L1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PHF20L1 mRNA21266533
C118739entinostatentinostat results in decreased expression of PHF20L1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PHF20L1 mRNA23649840
C039281furanfuran results in decreased expression of PHF20L1 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of PHF20L1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of PHF20L1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PHF20L1 mRNA18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHF20L1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHF20L1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHF20L1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PHF20L1 mRNA28628672
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PHF20L1 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PHF20L1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PHF20L1 mRNA23649840
C012655nimesulidenimesulide results in decreased expression of PHF20L1 mRNA24136188
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PHF20L1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PHF20L1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PHF20L1 mRNA26794494
D010634PhenobarbitalPhenobarbital affects the expression of PHF20L1 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PHF20L1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of PHF20L1 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of PHF20L1 mRNA19690047
D012402RotenoneRotenone results in decreased expression of PHF20L1 mRNA19013527
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PHF20L1 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of PHF20L1 mRNA23922661
C016104sodium bichromatesodium bichromate affects the expression of PHF20L1 mRNA22110744
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PHF20L1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF20L1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF20L1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF20L1 mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of PHF20L1 mRNA16870260
D013853ThioacetamideThioacetamide results in decreased expression of PHF20L1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of PHF20L1 mRNA23409001
D014050TolueneToluene results in increased expression of PHF20L1 mRNA22967744
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PHF20L1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PHF20L1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PHF20L1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PHF20L1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF20L1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PHF20L1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PHF20L1 gene25560391
C025643vinclozolinvinclozolin affects the expression of PHF20L1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of PHF20L1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16415788  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal