Gene: SBDS

51119
CGI-97|SDS|SWDS
SBDS, ribosome maturation factor
protein-coding
7q11.21
Ensembl:ENSG00000126524 MIM:607444 Vega:OTTHUMG00000023165 UniprotKB:Q9Y3A5
NG_007277.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.207e-1 (AD)  1.744e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNBP0.961
BTF30.956
NPM10.951
EIF10.943
UBE2E10.943
TMEM590.937
HNRNPC0.936
HMGB10.928
METAP20.928
DAZAP20.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.845
OR4F5-0.839
SDIM1-0.115
FANCD2OS-0.113
RNF223-0.112
MTRNR2L6-0.111
PRDM14-0.111
MTRNR2L3-0.11
MROH9-0.11
CXCL17-0.107

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SBDS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SBDS mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SBDS mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of SBDS mRNA"19561079
D000082AcetaminophenAcetaminophen affects the expression of SBDS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SBDS gene27153756
D001151ArsenicArsenic results in decreased expression of SBDS mRNA27838757
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SBDS mRNA21569818|2222880
C006780bisphenol Abisphenol A results in increased methylation of SBDS promoter27312807
C006780bisphenol Abisphenol A results in increased expression of SBDS mRNA25181051
C032036bromobenzenebromobenzene results in decreased expression of SBDS mRNA12628495
C018475butyraldehydebutyraldehyde results in increased expression of SBDS mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SBDS mRNA23650126
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of SBDS mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of SBDS mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of SBDS mRNA17211630
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SBDS mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of SBDS mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SBDS mRNA"22485181
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of SBDS mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SBDS mRNA17475347
C024565ethylene dichlorideethylene dichloride results in decreased expression of SBDS mRNA28189721
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SBDS mRNA21179406
C492448ICG 001ICG 001 results in decreased expression of SBDS mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SBDS mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SBDS mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SBDS mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SBDS mRNA23086925
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SBDS protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SBDS mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SBDS mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of SBDS mRNA23358140
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SBDS protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of SBDS mRNA18301758
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SBDS mRNA25895662
D018038Sodium SeleniteSodium Selenite results in increased expression of SBDS mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SBDS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SBDS mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SBDS mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SBDS mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SBDS mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SBDS mRNA"26179874
D014520UrethaneUrethane results in increased expression of SBDS mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI17475909  17643419  21044950  26871637  
GO:0008017microtubule binding-IDA18324336  
GO:0019843rRNA binding-IDA17475909  
GO:0043022ribosome binding-IDA21536732  
GO ID GO Term Qualifier Evidence PubMed
GO:0001833inner cell mass cell proliferation-IEA-  
GO:0006364rRNA processing-IMP17643419  
GO:0007052mitotic spindle organization-IDA18324336  
GO:0008283cell proliferation-IMP19759903  
GO:0030282bone mineralization-IMP17920346  
GO:0030595leukocyte chemotaxis-IDA14743349  
GO:0042256mature ribosome assembly-IDA21536732  
GO:0048539bone marrow development-IMP15342903  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IDA18324336  19759903  
GO:0005634nucleus-IDA15860664  18324336  
GO:0005654nucleoplasm-IEA-  
GO:0005730nucleolus-IDA15860664  17475909  
GO:0005737cytoplasm-IDA15860664  18324336  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal