Gene info: ID 51129

Gene: ANGPTL4

GENE ID: 51129

Description: angiopoietin like 4

Gene type: protein-coding

Location: 19p13.2

dbXrefs: Ensembl:ENSG00000167772 MIM:605910 Vega:OTTHUMG00000182273 UniprotKB:Q9BY76

RefSeq: NG_012169.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.023e-1 (AD) 5.563e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MT1X	0.856
FAM189A2	0.828
MT1A	0.825
TMBIM1	0.813
TRAF3IP2	0.799
PLIN2	0.798
MT1M	0.793
ITGB4	0.786
LIMK2	0.779
ITPKB	0.775

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HAPLN1	-0.508
KCNS3	-0.501
IGF1	-0.494
EDN3	-0.486
ZNF385D	-0.48
VWC2	-0.474
NXPH2	-0.472
C1QTNF2	-0.469
ADRA1D	-0.468
LBH	-0.467

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ANGPTL4 mRNA	25596134
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ANGPTL4 mRNA	25596134
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANGPTL4 mRNA"	21354444
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of ANGPTL4 mRNA	23792671
C000591541	1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine	"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA]"	24403227
C000591541	1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine	"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased expression of ANGPTL4 mRNA"	24403227
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of ANGPTL4 mRNA	28329830
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of ANGPTL4 mRNA"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ANGPTL4 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ANGPTL4 mRNA]"	19414516
C525485	2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole	"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole affects the expression of ANGPTL4 mRNA"	27665778
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ANGPTL4 mRNA"	21724226
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of ANGPTL4 mRNA"	25710175
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ANGPTL4 mRNA"	28433925
C011269	2,5-hexanedione	"2,5-hexanedione affects the expression of ANGPTL4 mRNA"	20616210
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter"	21489049
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA"	21489049\|2148904
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[decitabine co-treated with trichostatin A] inhibits the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA]"	21489049\|2148904
C012796	2-butenal	2-butenal results in decreased expression of ANGPTL4 mRNA	20471460
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of ANGPTL4 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ANGPTL4 mRNA]	23625689
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of ANGPTL4 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of ANGPTL4 mRNA	23625689
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ANGPTL4 mRNA"	28973690
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of ANGPTL4 mRNA	25716159
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ANGPTL4 mRNA"	18648102
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of ANGPTL4 mRNA"	21346803
C547957	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]	20516370
C547957	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]	20516370
C547957	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]	20516370
C547957	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide	[4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide results in increased activity of PPARD protein] promotes the reaction [PPARD protein binds to ANGPTL4 promoter]	20516370
C547957	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide	GW0742 inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]	20516370
C547957	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide	PPARD gene mutant form inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]]	20516370
D000082	Acetaminophen	Acetaminophen affects the expression of ANGPTL4 mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of ANGPTL4 mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in increased expression of ANGPTL4 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ANGPTL4 mRNA	17562736
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA	22129741
D000117	Acetylglucosamine	Acetylglucosamine results in decreased expression of ANGPTL4 mRNA	18047607
D000117	Acetylglucosamine	Acetylglucosamine results in increased expression of ANGPTL4 mRNA	18047607
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased expression of ANGPTL4 mRNA	25596134
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ANGPTL4 mRNA]"	19414516
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of ANGPTL4 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ANGPTL4 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ANGPTL4 mRNA	19770486
D000638	Amiodarone	Amiodarone affects the expression of ANGPTL4 mRNA	25064622
D000638	Amiodarone	Amiodarone results in increased expression of ANGPTL4 mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ANGPTL4 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ANGPTL4 mRNA	24449571
C519728	archazolid B	archazolid B results in increased expression of ANGPTL4 mRNA	25218289
C547126	AZM551248	AZM551248 results in increased expression of ANGPTL4 mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of ANGPTL4 mRNA	23656298
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANGPTL4 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANGPTL4 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of ANGPTL4 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ANGPTL4 mRNA	20064835\|2231617
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANGPTL4 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ANGPTL4 mRNA	19770486\|2171566
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ANGPTL4 mRNA	21569818\|2222880
D004958	Estradiol	Estradiol results in decreased expression of ANGPTL4 mRNA	25321415
C095105	bexarotene	bexarotene results in increased expression of ANGPTL4 mRNA	21622945
D001629	Bezafibrate	Bezafibrate results in increased expression of ANGPTL4 mRNA	17118139
D015082	2,2'-Dipyridyl	"2,2'-Dipyridyl results in increased expression of ANGPTL4 mRNA"	19924283
C006780	bisphenol A	bisphenol A results in decreased expression of ANGPTL4 mRNA	27685785
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ANGPTL4 mRNA"	28433925
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of ANGPTL4 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of ANGPTL4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ANGPTL4 gene	28505145
D002104	Cadmium	Cadmium results in increased expression of ANGPTL4 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ANGPTL4 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ANGPTL4 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ANGPTL4 mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of ANGPTL4 promoter	22457795
D002110	Caffeine	Caffeine results in decreased expression of ANGPTL4 mRNA	23774253
D002220	Carbamazepine	Carbamazepine results in decreased expression of ANGPTL4 mRNA	23774253
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ANGPTL4 mRNA	17484886
D002509	Cephaloridine	Cephaloridine results in increased expression of ANGPTL4 mRNA	18500788
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of ANGPTL4 mRNA	25596134
C100187	chloropicrin	chloropicrin results in decreased expression of ANGPTL4 mRNA	28476498
C100187	chloropicrin	chloropicrin results in increased expression of ANGPTL4 mRNA	26352163
D002737	Chloroprene	Chloroprene results in increased expression of ANGPTL4 mRNA	23125180
D002737	Chloroprene	Chloroprene results in decreased expression of ANGPTL4 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of ANGPTL4 mRNA	25064622
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of ANGPTL4 mRNA	21356183
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in decreased expression of ANGPTL4 mRNA	21356183
D008076	Cholesterol, HDL	"ANGPTL4 protein polymorphism results in increased abundance of Cholesterol, HDL"	28842503
D008078	Cholesterol, LDL	"ANGPTL4 protein polymorphism results in decreased abundance of Cholesterol, LDL"	28842503
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ANGPTL4 mRNA	27858113
C059262	cidofovir	cidofovir results in increased expression of ANGPTL4 mRNA	25596134
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of ANGPTL4 mRNA	16197558
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of ANGPTL4 mRNA	16197558
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of ANGPTL4 mRNA	25596134
D002994	Clofibrate	Clofibrate results in decreased expression of ANGPTL4 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of ANGPTL4 mRNA	12851107\|2766577
D002995	Clofibric Acid	Clofibric Acid results in increased expression of ANGPTL4 mRNA	21214675
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ANGPTL4 mRNA	17602206
D003035	Cobalt	[tungsten carbide binds to Cobalt] which results in increased expression of ANGPTL4 mRNA	20105288
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of ANGPTL4 mRNA	18078969
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ANGPTL4 mRNA	19320972\|2010528
C018021	cobaltous chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANGPTL4 mRNA]	22202117
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ANGPTL4 mRNA	24386269
C060728	cobalt oxide	cobalt oxide analog results in increased expression of ANGPTL4 mRNA	24821434
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in decreased expression of ANGPTL4 mRNA	21356183
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of ANGPTL4 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of ANGPTL4 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ANGPTL4 mRNA	19549813
D003314	Corn Oil	Corn Oil affects the expression of ANGPTL4 mRNA	16360708
C030973	cupric oxide	cupric oxide results in decreased expression of ANGPTL4 mRNA	22077320
D016572	Cyclosporine	Cyclosporine affects the expression of ANGPTL4 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of ANGPTL4 mRNA	27989131
C014347	decitabine	decitabine affects the expression of ANGPTL4 mRNA	23300844
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of ANGPTL4 mRNA	21489049
C014347	decitabine	decitabine results in increased expression of ANGPTL4 mRNA	17908484
C014347	decitabine	"[decitabine co-treated with trichostatin A] inhibits the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA]"	21489049\|2148904
C107676	deguelin	deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA]	22745725
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA	23428407
D003907	Dexamethasone	ANGPTL4 affects the susceptibility to Dexamethasone	19628874
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of ANGPTL4 mRNA	22733784
D003907	Dexamethasone	Dexamethasone results in increased expression of ANGPTL4 mRNA	19628874
D003907	Dexamethasone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Freund's Adjuvant results in decreased expression of ANGPTL4 mRNA]	21149847
D003907	Dexamethasone	Dexamethasone results in increased expression of ANGPTL4 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of ANGPTL4 mRNA]	20032058
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ANGPTL4 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of ANGPTL4 mRNA	28962523
D002945	Cisplatin	Cisplatin affects the expression of ANGPTL4 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of ANGPTL4 mRNA	20705681
D002945	Cisplatin	Cisplatin results in increased expression of ANGPTL4 mRNA	25596134
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form] results in decreased expression of ANGPTL4 mRNA	23625948
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of AGPAT2 mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of CD36 mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of DGAT2 mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of LPIN1 mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of SREBF1 mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of FASN mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of G6PC mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of MLXIPL mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of PCK1 mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]	28842503
D004041	Dietary Fats	ANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]	28842503
D004041	Dietary Fats	Dietary Fats results in decreased expression of ANGPTL4 mRNA	18042831\|2501614
D004041	Dietary Fats	Dietary Fats results in increased expression of ANGPTL4 mRNA	16357043\|1845759
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ANGPTL4 mRNA	28085963
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ANGPTL4 mRNA"	28433925
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ANGPTL4 mRNA	17602206
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA	22129741
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased methylation of ANGPTL4 promoter"	21489049
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA"	21489049\|2148904
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ANGPTL4 mRNA"	27840820
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of ANGPTL4 mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of ANGPTL4 mRNA	25152437
C118739	entinostat	entinostat results in increased expression of ANGPTL4 mRNA	27188386
D004967	Estrogens	Estrogens results in decreased expression of ANGPTL4 mRNA	22350948
D004967	Estrogens	Progesterone inhibits the reaction [Estrogens results in decreased expression of ANGPTL4 mRNA]	22350948
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ANGPTL4 mRNA	25064622
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of ANGPTL4 mRNA	28189721
D005230	Fatty Acids, Nonesterified	"ANGPTL4 protein results in increased abundance of Fatty Acids, Nonesterified"	19805517
D011345	Fenofibrate	Fenofibrate results in increased expression of ANGPTL4 mRNA	25572481\|2559613
D011345	Fenofibrate	Fenofibrate results in increased expression of ANGPTL4 mRNA	17118139
D011345	Fenofibrate	Fenofibrate results in increased expression of ANGPTL4 mRNA	25596134\|2766577
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of ANGPTL4 mRNA	16197558
D005411	Flame Retardants	Flame Retardants results in increased expression of ANGPTL4 mRNA	27219277
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of ANGPTL4 mRNA	28329830
D005472	Fluorouracil	ANGPTL4 protein affects the susceptibility to Fluorouracil	16217747
D005485	Flutamide	Flutamide results in decreased expression of ANGPTL4 mRNA	24136188\|2479361
D005557	Formaldehyde	Formaldehyde results in decreased expression of ANGPTL4 mRNA	28937961
D005620	Freund's Adjuvant	Dexamethasone inhibits the reaction [Freund's Adjuvant results in decreased expression of ANGPTL4 mRNA]	21149847
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of ANGPTL4 mRNA	21149847
C069837	fullerene C60	fullerene C60 results in decreased expression of ANGPTL4 mRNA	19167457
C039281	furan	furan results in decreased expression of ANGPTL4 mRNA	26194646
C546771	gardiquimod	gardiquimod results in increased expression of ANGPTL4 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ANGPTL4 mRNA]	28003376
D015248	Gemfibrozil	Gemfibrozil results in increased expression of ANGPTL4 mRNA	27665778
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of ANGPTL4 mRNA]	22687549
D005947	Glucose	Glucose results in increased expression of ANGPTL4 mRNA	16805838
D005990	Glycerol	ANGPTL4 protein modified form results in increased secretion of Glycerol	28842503
D005990	Glycerol	ANGPTL4 protein polymorphism results in increased secretion of Glycerol	28842503
D005990	Glycerol	ANGPTL4 protein results in increased secretion of Glycerol	28842503
D005990	Glycerol	ANGPTL4 protein affects the abundance of Glycerol	19805517
C479979	GW0742	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]	20516370
C479979	GW0742	[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of ANGPTL4 mRNA	28962521
C479979	GW0742	[GW0742 co-treated with PPARD protein] results in increased expression of ANGPTL4 mRNA	24464939
C479979	GW0742	GW0742 results in increased expression of ANGPTL4 mRNA	19415698\|2051637
C479979	GW0742	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]	20516370
C479979	GW0742	4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]	20516370
C479979	GW0742	GW0742 inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide promotes the reaction [PPARD protein binds to ANGPTL4 promoter]]	20516370
C479979	GW0742	[GW0742 results in increased activity of PPARD protein] promotes the reaction [PPARD protein binds to ANGPTL4 promoter]	20516370
C479979	GW0742	GW0742 results in increased expression of ANGPTL4 mRNA	20516370\|2742749
C479979	GW0742	PPARD gene mutant form inhibits the reaction [4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]]	20516370
C479979	GW0742	PPARD gene mutant form inhibits the reaction [GW0742 results in increased expression of ANGPTL4 mRNA]	20516370\|2776581
C425931	GW 501516	[GW 501516 binds to PPARD protein] which results in increased expression of ANGPTL4 mRNA	16197558
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers results in increased expression of ANGPTL4 mRNA	27219277
D007052	Ibuprofen	Ibuprofen results in increased expression of ANGPTL4 mRNA	25596134
D007052	Ibuprofen	Ibuprofen results in decreased expression of ANGPTL4 mRNA	28201806
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of ANGPTL4 mRNA"	26377693
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA	22129741
D007213	Indomethacin	Indomethacin results in increased expression of ANGPTL4 mRNA	16984733\|1941569
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANGPTL4 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA	23428407
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
C544151	jinfukang	jinfukang results in increased expression of ANGPTL4 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of ANGPTL4 mRNA	24796395\|2675264
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ANGPTL4 mRNA	25982114
D007649	Ketamine	Ketamine results in increased expression of ANGPTL4 mRNA	20080153
C045463	leflunomide	leflunomide results in increased expression of ANGPTL4 mRNA	28988120
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ANGPTL4 mRNA"	18930950
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of ANGPTL4 mRNA]	22687549
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of ANGPTL4 mRNA	26582142
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ANGPTL4 mRNA	22687549
C106335	macrophage stimulatory lipopeptide 2	[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of ANGPTL4 mRNA	18832182
D008345	Manganese	Manganese results in increased expression of ANGPTL4 mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of ANGPTL4 mRNA	17175027
D008687	Metformin	Metformin results in decreased expression of ANGPTL4 mRNA	25596134
C002950	methylformamide	methylformamide analog results in increased expression of ANGPTL4 mRNA	17040096
C002950	methylformamide	methylformamide results in increased expression of ANGPTL4 mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ANGPTL4 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ANGPTL4 mRNA	28001369
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of ANGPTL4 mRNA	17412507
C523799	MRK 003	ANGPTL4 results in increased susceptibility to MRK 003	19903844
C500085	muraglitazar	muraglitazar results in increased expression of ANGPTL4 mRNA	21515302
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of ANGPTL4 mRNA	16052530
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ANGPTL4 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ANGPTL4 mRNA"	25554681\|2562005
C031721	naphthalene	naphthalene results in increased expression of ANGPTL4 mRNA	18978301
C051752	nefazodone	nefazodone results in decreased expression of ANGPTL4 mRNA	24136188
D009532	Nickel	Nickel results in increased expression of ANGPTL4 mRNA	25583101
D009532	Nickel	Nickel results in increased expression of ANGPTL4 mRNA	12540486
C022838	nickel chloride	nickel chloride results in increased expression of ANGPTL4 mRNA	17312168\|2145529
C029938	nickel sulfate	[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of ANGPTL4 mRNA	18832182
C029938	nickel sulfate	nickel sulfate results in increased expression of ANGPTL4 mRNA	17382205\|1883218
C029938	nickel sulfate	nickel sulfate results in increased expression of ANGPTL4 mRNA	16166746
C012655	nimesulide	nimesulide results in increased expression of ANGPTL4 mRNA	19415698
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of ANGPTL4 mRNA	20971185
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of ANGPTL4 mRNA	24888373
D009966	Orphenadrine	Orphenadrine affects the expression of ANGPTL4 mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ANGPTL4 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of ANGPTL4 mRNA	25729387
D010100	Oxygen	"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA]"	24403227
D010100	Oxygen	deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA]	22745725
D010100	Oxygen	Oxygen deficiency results in increased expression of ANGPTL4 mRNA	17175027\|1992428
D010100	Oxygen	Oxygen deficiency results in increased expression of ANGPTL4 mRNA	20880076
D010100	Oxygen	Oxygen results in decreased expression of ANGPTL4 mRNA	22535284
D010126	Ozone	Ozone results in increased expression of ANGPTL4 mRNA	28652203
D010126	Ozone	Ozone results in increased expression of ANGPTL4 mRNA	17095637
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of ANGPTL4 mRNA	20705681
D000073878	Palm Oil	Palm Oil results in decreased expression of ANGPTL4 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of ANGPTL4 mRNA	17379144
D010269	Paraquat	Paraquat affects the expression of ANGPTL4 mRNA	25064622
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of ANGPTL4 mRNA]	28655636
D052638	Particulate Matter	Particulate Matter results in decreased expression of ANGPTL4 mRNA	28655636
D052638	Particulate Matter	[ANGPTL4 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of ANGPTL4 mRNA	21222557\|2122255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ANGPTL4 mRNA	26705709
C108042	perfluorobutane	perfluorobutane results in increased expression of ANGPTL4 mRNA	23567314
C033094	perfluorobutyric acid	perfluorobutyric acid results in decreased expression of ANGPTL4 mRNA	23567314
C036567	perfluorodecanoic acid	perfluorodecanoic acid affects the expression of ANGPTL4 mRNA	23567314
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in increased expression of ANGPTL4 mRNA	23567314
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid affects the expression of ANGPTL4 mRNA	23567314
C479228	perfluorohexanoic acid	perfluorohexanoic acid results in increased expression of ANGPTL4 mRNA	23567314
C101815	perfluoro-n-heptanoic acid	perfluoro-n-heptanoic acid results in increased expression of ANGPTL4 mRNA	23567314
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of ANGPTL4 mRNA	23567314
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of ANGPTL4 mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of ANGPTL4 mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of ANGPTL4 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ANGPTL4 mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ANGPTL4 mRNA	23567314\|2715376
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of ANGPTL4 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ANGPTL4 mRNA	18467677
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ANGPTL4 mRNA	28511854
D010634	Phenobarbital	Phenobarbital results in decreased expression of ANGPTL4 mRNA	19270015\|2309116
D010634	Phenobarbital	Phenobarbital results in increased expression of ANGPTL4 mRNA	19270015
D010656	Phenylephrine	Phenylephrine results in decreased expression of ANGPTL4 mRNA	18158353
C006253	pirinixic acid	pirinixic acid results in increased expression of ANGPTL4 mRNA	23811191\|2755195
C006253	pirinixic acid	pirinixic acid results in decreased expression of ANGPTL4 mRNA	16985257
C006253	pirinixic acid	pirinixic acid results in increased expression of ANGPTL4 mRNA	16357043\|1711813
C006253	pirinixic acid	MDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ANGPTL4 mRNA]	19103650
C006253	pirinixic acid	[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ANGPTL4 mRNA	19103650
C006253	pirinixic acid	pirinixic acid results in increased expression of ANGPTL4 mRNA	16940010\|2766577
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of ANGPTL4 mRNA	21334430
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of ANGPTL4 mRNA	24888373
D011137	Polystyrenes	Polystyrenes results in increased expression of ANGPTL4 mRNA	25102311
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ANGPTL4 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of ANGPTL4 mRNA	21795739
D011374	Progesterone	Progesterone inhibits the reaction [Estrogens results in decreased expression of ANGPTL4 mRNA]	22350948
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ANGPTL4 mRNA	24780913
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ANGPTL4 mRNA]	28003376
D011794	Quercetin	Quercetin results in decreased expression of ANGPTL4 mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of ANGPTL4	24722352
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in decreased expression of ANGPTL4 mRNA	25905778
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of ANGPTL4 mRNA	21127053
C089730	rosiglitazone	[rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of ANGPTL4 mRNA	28962521
C089730	rosiglitazone	rosiglitazone results in increased expression of ANGPTL4 mRNA	25572481\|2559613
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA	16054899
C089730	rosiglitazone	rosiglitazone results in increased expression of ANGPTL4 mRNA	21622945
C089730	rosiglitazone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
C089730	rosiglitazone	rosiglitazone results in increased expression of ANGPTL4 mRNA	21172411\|2151530
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ANGPTL4 mRNA	21427059
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ANGPTL4 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ANGPTL4 mRNA	19073995
D012834	Silver	Silver affects the expression of ANGPTL4 mRNA	27131904
D019821	Simvastatin	Simvastatin results in increased expression of ANGPTL4 mRNA	19262002
D012906	Smoke	Smoke results in increased expression of ANGPTL4 mRNA	20015843
C017947	sodium arsenite	sodium arsenite results in decreased expression of ANGPTL4 mRNA	20371982
D053260	Soot	Soot affects the expression of ANGPTL4 mRNA	26551751
D053260	Soot	Soot results in increased expression of ANGPTL4 mRNA	22461453
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in decreased expression of ANGPTL4 mRNA	25905778
C501413	tesaglitazar	tesaglitazar results in increased expression of ANGPTL4 mRNA	21515302
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of ANGPTL4 mRNA	26496021
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of ANGPTL4 mRNA]	20032058
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of ANGPTL4 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ANGPTL4 mRNA]	23625689
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ANGPTL4 mRNA	23625689
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ANGPTL4 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ANGPTL4 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of ANGPTL4 mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ANGPTL4 mRNA	16054899\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ANGPTL4 mRNA	16960034
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ANGPTL4 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ANGPTL4 mRNA	21215274\|2172422
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ANGPTL4 mRNA	16960034
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ANGPTL4 mRNA	28973375
D013752	Tetracycline	Tetracycline affects the expression of ANGPTL4 mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANGPTL4 mRNA	25613284
D013853	Thioacetamide	Thioacetamide affects the expression of ANGPTL4 mRNA	25064622
C009495	titanium dioxide	titanium dioxide results in decreased expression of ANGPTL4 mRNA	19464567
C009495	titanium dioxide	titanium dioxide results in increased expression of ANGPTL4 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ANGPTL4 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ANGPTL4 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ANGPTL4 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of ANGPTL4 mRNA	23774253
D014212	Tretinoin	Tretinoin results in increased expression of ANGPTL4 mRNA	15894607\|2372400
C011559	tributyltin	tributyltin results in increased expression of ANGPTL4 mRNA	21622945\|2342840
C011559	tributyltin	tributyltin results in increased expression of ANGPTL4 mRNA	21683754
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ANGPTL4 mRNA	25549359\|2897337
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of ANGPTL4 mRNA	21489049
C012589	trichostatin A	"[decitabine co-treated with trichostatin A] inhibits the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA]"	21489049\|2148904
D014280	Triglycerides	ANGPTL4 protein polymorphism results in decreased abundance of Triglycerides	28842503
D014280	Triglycerides	ANGPTL4 protein results in increased abundance of Triglycerides	19805517
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of ANGPTL4 mRNA	26898711
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ANGPTL4 mRNA	29024780
C057693	troglitazone	troglitazone results in increased expression of ANGPTL4 mRNA	19140230\|2557248
C057693	troglitazone	troglitazone results in decreased expression of ANGPTL4 mRNA	28973697
C057693	troglitazone	troglitazone results in increased expression of ANGPTL4 mRNA	28973697
C057693	troglitazone	troglitazone results in increased expression of ANGPTL4 mRNA	21515302
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ANGPTL4 mRNA"	18930950
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which results in increased expression of ANGPTL4 mRNA	20105288
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of ANGPTL4 mRNA	18078969
D014635	Valproic Acid	Valproic Acid affects the expression of ANGPTL4 mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in decreased expression of ANGPTL4 mRNA	23774253
D014635	Valproic Acid	Valproic Acid affects the expression of ANGPTL4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of ANGPTL4 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased expression of ANGPTL4 mRNA	21427059
D014640	Vancomycin	Vancomycin results in decreased expression of ANGPTL4 mRNA	18930951
D001335	Vehicle Emissions	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of ANGPTL4 mRNA]	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of ANGPTL4 mRNA	28655636
D001335	Vehicle Emissions	[ANGPTL4 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of ANGPTL4 mRNA	21222557\|2122255
D014752	Vinyl Chloride	Vinyl Chloride results in decreased expression of ANGPTL4 mRNA	18579281
C016837	zinc chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANGPTL4 mRNA]	22202117

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004857	enzyme inhibitor activity	-	ISS	-
GO:0005515	protein binding	-	IPI	21397862
GO:0042802	identical protein binding	-	IPI	19028676

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEA	-
GO:0001666	response to hypoxia	-	NAS	12707035
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0030154	cell differentiation	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IDA	10698685
GO:0045766	positive regulation of angiogenesis	-	TAS	11953136
GO:0051005	negative regulation of lipoprotein lipase activity	-	IDA	19542565
GO:0051260	protein homooligomerization	-	IEA	-
GO:0070328	triglyceride homeostasis	-	ISS	-
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	10698685
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	10698685
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa03320	PPAR signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	TAS
R-HSA-8963899	Plasma lipoprotein remodeling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23183503	Variants within HNF1alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study. (2012)	Dlouha D	Neuro Endocrinol Lett
24641868	Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens. (2014 May)	Evans RL	Cancer Prev Res (Phila)
18599063	Carbohydrate intake modifies associations between ANGPTL4[E40K] genotype and HDL-cholesterol concentrations in White men from the Atherosclerosis Risk in Communities (ARIC) study. (2009 Mar)	Nettleton JA	Atherosclerosis
29538435	Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study. (2018)	Morinaga J	PLoS One