Gene: INSIG2

51141
INSIG-2
insulin induced gene 2
protein-coding
2q14.1-q14.2
Ensembl:ENSG00000125629 MIM:608660 Vega:OTTHUMG00000058518 UniprotKB:Q9Y5U4
NC_000002.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.906e-1 (AD)  3.454e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SACM1L0.959
VPS350.958
UBE2K0.958
KLHL70.957
CUL20.954
CAND10.953
COL4A3BP0.952
RANBP60.95
TRIM230.949
BCAP290.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.565
OR4F29-0.524
CSAG1-0.406
HEY2-0.379
MTRNR2L10-0.357
MTRNR2L6-0.352
MYL3-0.351
ZBTB20-0.341
ASB4-0.337
RAI14-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of INSIG2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of INSIG2 mRNA"19850644|2135444
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of INSIG2 mRNA]"19850644
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of INSIG2 mRNA]"24403227
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of INSIG2 mRNA"20056577
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of INSIG2 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of INSIG2 mRNA"20005886|2185183
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG2 mRNA"28433925
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of INSIG2 mRNA]"21851831
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of INSIG2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of INSIG2 mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of INSIG2 mRNA19191707
C0293704-toluidine4-toluidine results in decreased expression of INSIG2 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of INSIG2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of INSIG2 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of INSIG2 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of INSIG2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of INSIG2 mRNA16483693
D014150Antipsychotic AgentsINSIG2 gene polymorphism affects the susceptibility to Antipsychotic Agents18195716
C519728archazolid Barchazolid B results in increased expression of INSIG2 mRNA25218289
D001151ArsenicArsenic affects the methylation of INSIG2 gene25304211
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of INSIG2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of INSIG2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of INSIG2 mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of INSIG2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of INSIG2 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of INSIG2 mRNA28628672
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG2 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of INSIG2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of INSIG2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INSIG2 mRNA28628672
D002104CadmiumCadmium results in increased expression of INSIG2 mRNA26187450
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of INSIG2 mRNA25596134
D002746ChlorpromazineChlorpromazine results in decreased expression of INSIG2 mRNA25596134
D002922CiguatoxinsCiguatoxins affects the expression of INSIG2 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of INSIG2 mRNA23811191
D002994ClofibrateClofibrate results in decreased expression of INSIG2 mRNA17126302
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of INSIG2 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of INSIG2 mRNA22202117
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of INSIG2 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of INSIG2 mRNA24386269
D003300CopperCopper deficiency results in decreased expression of INSIG2 mRNA19821111
D019327Copper SulfateCopper Sulfate results in decreased expression of INSIG2 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]18704882
D016572CyclosporineCyclosporine results in decreased expression of INSIG2 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of INSIG2 mRNA20106945|2559613
D016572CyclosporineCyclosporine results in decreased expression of INSIG2 mRNA19770486
D016572CyclosporineCyclosporine results in decreased expression of INSIG2 mRNA25596134
C014347decitabinedecitabine results in increased expression of INSIG2 mRNA19194470
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of INSIG2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INSIG2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of INSIG2 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in decreased expression of INSIG2 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of INSIG2 mRNA23153324
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of INSIG2 mRNA28433925
D004041Dietary Fats[Quercetin co-treated with Dietary Fats] affects the expression of INSIG2 mRNA23359794
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of INSIG2 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSIG2 mRNA27614199
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of INSIG2 mRNA19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of INSIG2 mRNA19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of INSIG2 mRNA19245819
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of INSIG2 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG2 mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of INSIG2 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of INSIG2 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of INSIG2 mRNA28943392
D002117CalcitriolCalcitriol results in increased expression of INSIG2 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of INSIG2 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of INSIG2 mRNA25380136
D004221DisulfiramDisulfiram results in decreased expression of INSIG2 mRNA20530235
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of INSIG2 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of INSIG2 mRNA21233418
D000431EthanolEthanol results in decreased expression of INSIG2 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of INSIG2 mRNA17108234
C024565ethylene dichlorideethylene dichloride results in increased expression of INSIG2 mRNA28189721
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of INSIG2 mRNA"23333450
D011345FenofibrateFenofibrate results in decreased expression of INSIG2 mRNA25596134
C082360fipronilfipronil results in increased expression of INSIG2 mRNA23962444
C061365flusilazoleflusilazole affects the expression of INSIG2 mRNA22634333
D005557FormaldehydeFormaldehyde results in decreased expression of INSIG2 mRNA23649840
D005632FructoseFructose results in increased expression of INSIG2 mRNA22698815
C039281furanfuran results in decreased expression of INSIG2 mRNA26194646
D005897GlafenineGlafenine results in decreased expression of INSIG2 mRNA24136188
C409722hexaconazolehexaconazole affects the expression of INSIG2 mRNA22045034
D017313FenretinideFenretinide results in decreased expression of INSIG2 mRNA28973697
D007069IfosfamideIfosfamide results in increased expression of INSIG2 mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of INSIG2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INSIG2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of INSIG2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of INSIG2 mRNA28628672
D007657Ketone BodiesKetone Bodies results in increased expression of INSIG2 mRNA16807920
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of INSIG2 mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of INSIG2 mRNA16415329
D008070LipopolysaccharidesRanitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG2 mRNA]16415329
D008687MetforminMetformin results in decreased expression of INSIG2 mRNA25596134
D008727MethotrexateMethotrexate affects the expression of INSIG2 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of INSIG2 mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of INSIG2 mRNA23649840
D015735MifepristoneMifepristone results in decreased expression of INSIG2 mRNA25972201
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of INSIG2 mRNA20024957
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of INSIG2 mRNA"29244179
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of INSIG2 mRNA16052530
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of INSIG2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of INSIG2 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of INSIG2 mRNA25380136
C051752nefazodonenefazodone results in increased expression of INSIG2 mRNA24136188
D019829NevirapineNevirapine results in increased expression of INSIG2 mRNA23947594
C029938nickel sulfatenickel sulfate results in increased expression of INSIG2 mRNA17382205
C016340o,p'-DDT"o,p'-DDT affects the expression of INSIG2 mRNA"18925944
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of INSIG2 mRNA]"24403227
D010100OxygenOxygen deficiency results in increased expression of INSIG2 mRNA24236059|2440322
C016030pantogabpantogab results in increased expression of INSIG2 mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of INSIG2 protein25092180
D010634PhenobarbitalPhenobarbital affects the expression of INSIG2 mRNA19159669
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of INSIG2 mRNA]19850644
D010634PhenobarbitalPhenobarbital affects the expression of INSIG2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of INSIG2 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of INSIG2 mRNA19850644
C006253pirinixic acidpirinixic acid results in increased expression of INSIG2 mRNA18445702|2081375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of INSIG2 protein19248225
C006253pirinixic acidpirinixic acid results in increased expression of INSIG2 mRNA17126302
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of INSIG2 mRNA28903501
D011794Quercetin[Quercetin co-treated with Dietary Fats] affects the expression of INSIG2 mRNA23359794
D011899RanitidineRanitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG2 mRNA]16415329
C031389resorcinolresorcinol results in increased expression of INSIG2 mRNA22623647
C089730rosiglitazonerosiglitazone results in decreased expression of INSIG2 mRNA25596134
C089730rosiglitazonerosiglitazone results in decreased expression of INSIG2 mRNA25596134
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of INSIG2 mRNA25895662
D019821SimvastatinSimvastatin results in decreased expression of INSIG2 mRNA25055962
C017947sodium arsenitesodium arsenite affects the expression of INSIG2 mRNA29319823
C017947sodium arsenitesodium arsenite results in decreased expression of INSIG2 mRNA25270620
C016104sodium bichromatesodium bichromate results in decreased expression of INSIG2 mRNA22155349
C016104sodium bichromatesodium bichromate results in decreased expression of INSIG2 mRNA25993096
D013311StreptozocinStreptozocin results in decreased expression of INSIG2 mRNA25905778
D013629TamoxifenTamoxifen affects the expression of INSIG2 mRNA20937368
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of INSIG2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of INSIG2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INSIG2 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of INSIG2 mRNA16214954
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of INSIG2 mRNA"28433925
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of INSIG2 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to INSIG2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of INSIG2 mRNA18796159|1977048
D013752TetracyclineTetracycline results in increased expression of INSIG2 mRNA16917069
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of INSIG2 mRNA28943392
D013893ThiramThiram results in decreased expression of INSIG2 mRNA20530235
C012589trichostatin Atrichostatin A affects the expression of INSIG2 mRNA28542535
D014303TrinitrotolueneTrinitrotoluene affects the expression of INSIG2 mRNA21346803
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of INSIG2 protein19248225
C057693troglitazonetroglitazone results in decreased expression of INSIG2 mRNA25596134
C406224valdecoxibvaldecoxib results in increased expression of INSIG2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of INSIG2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of INSIG2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of INSIG2 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of INSIG2 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of INSIG2 mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of INSIG2 mRNA19136453|2054688
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of INSIG2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of INSIG2 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of INSIG2 mRNA20044591
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of INSIG2 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12242332  25416956  
GO:0008134transcription factor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006641triglyceride metabolic process-IEA-  
GO:0006695cholesterol biosynthetic process-IEA-  
GO:0010894negative regulation of steroid biosynthetic process-IEA-  
GO:0032868response to insulin-IEA-  
GO:0032933SREBP signaling pathway-IDA12242332  
GO:0042472inner ear morphogenesis-IEA-  
GO:0042474middle ear morphogenesis-IEA-  
GO:0045717negative regulation of fatty acid biosynthetic process-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060363cranial suture morphogenesis-IEA-  
GO:0070542response to fatty acid-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0032937SREBP-SCAP-Insig complex-IDA12242332  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)IEA
R-HSA-556833Metabolism of lipidsIEA
R-HSA-8957322Metabolism of steroidsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18570692The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women. (2009 Feb)Oki KBr J Nutr
22038464Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content. (2012 Oct)Barth SWEur J Nutr