Gene: SLC45A2

51151
1A1|AIM1|MATP|OCA4|SHEP5
solute carrier family 45 member 2
protein-coding
5p13.2
Ensembl:ENSG00000164175 MIM:606202 Vega:OTTHUMG00000090719 UniprotKB:Q9UMX9
NG_011691.2
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.229e-1 (AD)  4.447e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs35405chr5:33945653 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LURAP1L0.501
RNF144A0.497
TOP3B0.487
NFASC0.485
DNA20.484
SLC22A230.484
BCO20.481
PRSS530.48
ANKLE10.475
AGPAT40.474

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNNT1-0.313
DIO2-0.286
KCNJ16-0.282
ANGPTL1-0.281
TNS3-0.276
FUT10-0.272
NXNL1-0.27
KCNK5-0.27
NT5E-0.266
S100A14-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC45A2 mRNA"25614096
C4879483-iodothyronamineSLC45A2 mRNA affects the uptake of 3-iodothyronamine19074582
D020106AcrylamideAcrylamide affects the expression of SLC45A2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC45A2 gene27153756
D001507BeclomethasoneBeclomethasone results in increased expression of SLC45A2 mRNA23656298
C006780bisphenol Abisphenol A results in decreased expression of SLC45A2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of SLC45A2 mRNA25181051
D005576ColforsinColforsin results in increased expression of SLC45A2 mRNA17460731
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SLC45A2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SLC45A2 mRNA26033743
D016572CyclosporineCyclosporine results in increased methylation of SLC45A2 promoter27989131
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SLC45A2 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC45A2 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of SLC45A2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SLC45A2 mRNA21592394
D017313FenretinideFenretinide results in decreased expression of SLC45A2 mRNA28973697
C018091maduramicinmaduramicin results in decreased expression of SLC45A2 mRNA29128925
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SLC45A2 mRNA27544571
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC45A2 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of SLC45A2 mRNA26079696
C059514resveratrolresveratrol results in decreased expression of SLC45A2 mRNA17460731
D018038Sodium SeleniteSodium Selenite results in decreased expression of SLC45A2 mRNA18175754
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SLC45A2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SLC45A2 mRNA21592394
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC45A2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008506sucrose:proton symporter activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-IEA-  
GO:0015770sucrose transport-ISS-  
GO:0042438melanin biosynthetic process-IEA-  
GO:0048066developmental pigmentation-IEA-  
GO:0050896response to stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0033162melanosome membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-5662702Melanin biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal