Gene: EGFL7

51162
NEU1|VE-STATIN|ZNEU1
EGF like domain multiple 7
protein-coding
9q34.3
Ensembl:ENSG00000172889 MIM:608582 Vega:OTTHUMG00000020938 UniprotKB:Q9UHF1
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.451e-1 (AD)  3.728e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7041558chr9:136664675 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13425938chr9:139562397EGFL71.830e-11Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUS1L0.829
BSG0.812
DPP70.81
CDC340.803
C9orf160.803
CDC370.797
SH3GL10.794
ARL6IP40.792
TMEM2590.79
LMF20.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.711
OR4F5-0.7
TAS2R3-0.21
PPIAP10-0.204
ISL1-0.202
OR10A2-0.201
LHX8-0.199
SIX3-0.199
OR9A2-0.194
SLITRK6-0.194

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of EGFL7 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EGFL7 mRNA"19114083
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of EGFL7 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of EGFL7 mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of EGFL7 mRNA alternative form19116145
C0757734-phenylbutyric acid[decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form19116145
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EGFL7 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EGFL7 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EGFL7 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of EGFL7 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of EGFL7 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of EGFL7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EGFL7 promoter]19654925
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of EGFL7 mRNA25566086
C006780bisphenol Abisphenol A results in increased expression of EGFL7 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of EGFL7 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of EGFL7 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of EGFL7 mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of EGFL7 mRNA26272509
C014347decitabine[decitabine co-treated with 4-phenylbutyric acid] results in increased expression of EGFL7 mRNA alternative form19116145
C014347decitabinedecitabine results in increased expression of EGFL7 mRNA alternative form19116145
D004041Dietary FatsDietary Fats results in increased expression of EGFL7 mRNA18042831
D004237DiuronDiuron results in increased expression of EGFL7 mRNA25152437
C118739entinostatentinostat results in increased expression of EGFL7 mRNA27188386
D005839GentamicinsGentamicins results in decreased expression of EGFL7 mRNA22061828
D005897GlafenineGlafenine results in increased expression of EGFL7 mRNA24136188
D017313FenretinideFenretinide results in increased expression of EGFL7 mRNA28973697
D007854LeadLead results in decreased expression of EGFL7 mRNA19921347
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA16415329
C025340manganese chloridemanganese chloride results in increased expression of EGFL7 mRNA17467022
C042720mercuric bromidemercuric bromide results in decreased expression of EGFL7 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of EGFL7 mRNA26307267
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFL7 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of EGFL7 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EGFL7 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EGFL7 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EGFL7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EGFL7 mRNA"25554681
D009532NickelNickel results in decreased expression of EGFL7 mRNA25583101
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of EGFL7 mRNA"12756304
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of EGFL7 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of EGFL7 mRNA18042831
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of EGFL7 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of EGFL7 mRNA28655636
D010634PhenobarbitalPhenobarbital results in increased expression of EGFL7 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGFL7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EGFL7 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of EGFL7 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EGFL7 mRNA19162173
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA16415329
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFL7 mRNA19564919
D014284TriiodothyronineTriiodothyronine results in increased expression of EGFL7 mRNA22281776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EGFL7 mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of EGFL7 mRNA27188386
D013849ThimerosalThimerosal results in decreased expression of EGFL7 mRNA24675092
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of EGFL7 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EGFL7 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EGFL7 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of EGFL7 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of EGFL7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EGFL7 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of EGFL7 gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of EGFL7 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of EGFL7 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EGFL7 gene25560391
C025643vinclozolinvinclozolin affects the expression of EGFL7 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of EGFL7 mRNA22570695
D019287Zinc SulfateZinc Sulfate results in decreased expression of EGFL7 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001568blood vessel development-ISS-  
GO:0001570vasculogenesis-ISS-  
GO:0001938positive regulation of endothelial cell proliferation-IMP20947685  
GO:0007155cell adhesion-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IMP20947685  
GO:0048856anatomical structure development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-ISS-  
GO:0005615extracellular space-IEA-  
GO:0009986cell surface-IBA21873635  
GO:0031012extracellular matrix-HDA23658023  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal