Gene: AADAT

51166
KAT2|KATII|KYAT2
aminoadipate aminotransferase
protein-coding
4q33
Ensembl:ENSG00000109576 MIM:611754 Vega:OTTHUMG00000160912 UniprotKB:Q8N5Z0
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.197e-1 (AD)  2.056e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2466990chr4:170072620 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MICU20.812
TOP2B0.807
GLT8D10.794
RNF1700.789
TFCP20.789
ZNF230.788
PLRG10.788
COA50.784
NAE10.784
RCOR30.783

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.61
OR4F29-0.595
SPINK8-0.306
MTRNR2L3-0.306
MTRNR2L10-0.301
MTRNR2L6-0.295
ARHGEF35-0.292
MTRNR2L9-0.282
C8orf74-0.281
DPPA4-0.277

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of AADAT mRNA"22016648
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AADAT mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AADAT mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AADAT mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of AADAT mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of AADAT mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AADAT mRNA21632981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AADAT mRNA19770486
D000452AldrinAldrin results in increased expression of AADAT mRNA18579281
D000638AmiodaroneAmiodarone affects the expression of AADAT mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of AADAT mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AADAT mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of AADAT mRNA"22863853
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AADAT mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AADAT mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AADAT mRNA"20018196
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of AADAT mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of AADAT mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of AADAT mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of AADAT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AADAT gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of AADAT mRNA18958704
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AADAT mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of AADAT mRNA18178546
D002994ClofibrateClofibrate results in increased expression of AADAT mRNA17585979|2381119
D002997ClomipramineClomipramine affects the expression of AADAT mRNA18355885
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of AADAT mRNA20971185
D003300CopperCopper results in decreased expression of AADAT mRNA22465980
D003471CuprizoneCuprizone affects the expression of AADAT mRNA27523638
D003471CuprizoneCuprizone results in increased expression of AADAT mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of AADAT mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AADAT mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of AADAT mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of AADAT mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AADAT mRNA24535843
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of AADAT mRNA25380136
D004317DoxorubicinDoxorubicin results in increased expression of AADAT mRNA22016648
D000431EthanolEthanol results in decreased expression of AADAT mRNA19167417
D005485FlutamideFlutamide results in decreased expression of AADAT mRNA24136188
C039281furanfuran results in increased methylation of AADAT gene22079235
C040029gabapentingabapentin results in decreased activity of AADAT protein16765940
D007099ImipramineImipramine affects the expression of AADAT mRNA18355885
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AADAT mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AADAT mRNA24796395|2675264
C410337K 7174K 7174 results in decreased expression of AADAT mRNA24086573
D007654KetoconazoleKetoconazole affects the expression of AADAT mRNA18355885
C008261lead acetatelead acetate results in increased expression of AADAT mRNA22641619
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of AADAT mRNA25380136
C051752nefazodonenefazodone results in decreased expression of AADAT mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of AADAT protein19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of AADAT mRNA20971185
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of AADAT mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of AADAT mRNA19482888
D010795Phthalic AcidsPhthalic Acids results in decreased expression of AADAT mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of AADAT mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AADAT mRNA19162173
D011794QuercetinQuercetin results in decreased expression of AADAT mRNA21632981
D012402RotenoneRotenone results in decreased expression of AADAT mRNA22016648
D012460SulfasalazineSulfasalazine results in increased expression of AADAT mRNA22016648
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of AADAT mRNA15885361
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of AADAT mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AADAT mRNA16054898|1879615
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AADAT mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of AADAT mRNA26217789
D013853ThioacetamideThioacetamide results in decreased expression of AADAT mRNA23411599
C059205tiagabinetiagabine results in decreased activity of AADAT protein16765940
D014050TolueneToluene results in increased expression of AADAT mRNA22166486
D014501UraniumUranium affects the expression of AADAT mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of AADAT mRNA15672453
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of AADAT mRNA15885361
D014635Valproic AcidValproic Acid affects the expression of AADAT mRNA25979313
D014640VancomycinVancomycin results in increased expression of AADAT mRNA18930951
D020888VigabatrinVigabatrin results in decreased activity of AADAT protein16765940
C025643vinclozolinvinclozolin results in increased expression of AADAT mRNA22570695
C029297vinylidene chloridevinylidene chloride results in decreased expression of AADAT mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of AADAT mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016212kynurenine-oxoglutarate transaminase activity-IDA18620547  
GO:0016212kynurenine-oxoglutarate transaminase activity-TAS-  
GO:0030170pyridoxal phosphate binding-IEA-  
GO:0042803protein homodimerization activity-IPI18620547  
GO:00475362-aminoadipate transaminase activity-EXP18056995  18056996  
GO:00475362-aminoadipate transaminase activity-IDA18620547  
GO ID GO Term Qualifier Evidence PubMed
GO:00061032-oxoglutarate metabolic process-IDA18620547  
GO:0006536glutamate metabolic process-IDA18620547  
GO:0006554lysine catabolic process-TAS-  
GO:0006569tryptophan catabolic process-TAS-  
GO:0009058biosynthetic process-IEA-  
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopine-IEA-  
GO:0070189kynurenine metabolic process-IDA18620547  
GO:0097052L-kynurenine metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00300Lysine biosynthesis
hsa00310Lysine degradation
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71064Lysine catabolismTAS
R-HSA-71240Tryptophan catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal