Gene: LEF1

51176
LEF-1|TCF10|TCF1ALPHA|TCF7L3
lymphoid enhancer binding factor 1
protein-coding
4q25
Ensembl:ENSG00000138795 MIM:153245 Vega:OTTHUMG00000131809 UniprotKB:Q9UJU2
NG_015798.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.689e-1 (AD)  1.112e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFBR20.875
ESAM0.875
MECOM0.866
FOXC10.865
MYCT10.862
CASP100.844
EMCN0.844
CLEC14A0.843
ABCB10.842
GATA20.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.426
SLC7A4-0.424
MYADML2-0.413
SMIM18-0.412
DRD5-0.401
MARCH4-0.398
SVOP-0.397
CRH-0.39
FBLL1-0.385
KLHL35-0.385

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00903Etacrynic acidSmall Molecule58-54-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEF1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEF1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEF1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEF1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEF1 mRNA"25510870
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of LEF1 mRNA15612046
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA"25381574
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]"25381574
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]"25381574
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LEF1 mRNA"23196670
C0484603-deazaneplanocin[3-deazaneplanocin co-treated with trichostatin A] affects the expression of LEF1 protein18538736
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of LEF1 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEF1 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of LEF1 mRNA22634333
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of LEF1 mRNA17093179
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LEF1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LEF1 mRNA16483693
D001151Arsenic[APOE protein affects the susceptibility to Arsenic] which affects the expression of LEF1 mRNA22719926
C015001arsenitearsenite results in increased methylation of LEF1 promoter23974009
D001280AtrazineAtrazine results in increased expression of LEF1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LEF1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LEF1 mRNA21839799
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of LEF1 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of LEF1 mRNA19484750|2521013
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of LEF1 mRNA26496021
D004958EstradiolEstradiol promotes the reaction [CTNNB1 protein binds to LEF1 protein]17170212
C006780bisphenol Abisphenol A affects the methylation of LEF1 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of LEF1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of LEF1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of LEF1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of LEF1 mRNA26496021
C006780bisphenol A"bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]"25381574
C006780bisphenol Abisphenol A inhibits the reaction [WNT3A protein results in increased expression of LEF1 mRNA]25381574
C006780bisphenol Abisphenol A results in decreased expression of LEF1 mRNA25381574|2596372
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA]25963729
C006780bisphenol A[DKK1 protein co-treated with bisphenol A] results in decreased expression of LEF1 mRNA25381574
C006780bisphenol A[FH535 co-treated with bisphenol A] results in decreased expression of LEF1 mRNA25381574
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of LEF1 mRNA22079614
D019328Buthionine Sulfoximine[Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of LEF1 protein27421576
D002084Butylated Hydroxytoluene[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA16272459
C027561butylbenzyl phthalatebutylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]22552774
C027561butylbenzyl phthalateHDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C027561butylbenzyl phthalatetrichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C054133casticincasticin results in decreased expression of LEF1 mRNA27862857
D004390ChlorpyrifosChlorpyrifos results in increased expression of LEF1 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LEF1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of LEF1 mRNA24386269
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA]25963729
D003474CurcuminCurcumin results in increased expression of LEF1 mRNA25963729
D003520CyclophosphamideCyclophosphamide results in decreased expression of LEF1 mRNA21041162
C014347decitabinedecitabine results in decreased expression of LEF1 mRNA19387464
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LEF1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of LEF1 mRNA21041162
D015946Ethylene DibromideEthylene Dibromide results in decreased expression of LEF1 mRNA15612046
D003993Dibutyl PhthalateDibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]22552774
D003993Dibutyl PhthalateHDAC6 mutant form inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
D003993Dibutyl Phthalatetrichostatin A inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LEF1 mRNA21266533
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA16931933
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of LEF1 mRNA17093179
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LEF1 mRNA21041162
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of LEF1 mRNA"27840820
D004642EmodinEmodin results in decreased expression of LEF1 mRNA15612046
D004726EndosulfanEndosulfan results in increased expression of LEF1 protein22677888
C118739entinostatentinostat results in increased expression of LEF1 mRNA27188386
D004976Ethacrynic AcidEthacrynic Acid binds to LEF1 protein20011538
D004976Ethacrynic AcidEthacrynic Acid results in decreased expression of LEF1 mRNA20011538
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LEF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEF1 mRNA17942748
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]26420483
D005013EthosuximideEthosuximide results in increased expression of LEF1 mRNA26420483
C575430FH535[FH535 co-treated with bisphenol A] results in decreased expression of LEF1 mRNA25381574
C575430FH535FH535 inhibits the reaction [WNT3A protein results in increased expression of LEF1 mRNA]25381574
C575430FH535FH535 results in decreased expression of LEF1 mRNA25381574
C575430FH535WNT3A protein promotes the reaction [FH535 results in decreased expression of LEF1 mRNA]25381574
D005419FlavonoidsFlavonoids results in increased expression of LEF1 mRNA18035473
C061365flusilazoleflusilazole affects the expression of LEF1 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LEF1 gene20938992
D002955Leucovorin[Methotrexate co-treated with Leucovorin] results in increased expression of LEF1 mRNA25187349
D005839GentamicinsGentamicins results in increased expression of LEF1 mRNA22061828
D005947GlucoseDKK1 protein inhibits the reaction [Glucose results in increased expression of LEF1 mRNA]29163160
D005947GlucoseGlucose results in increased expression of LEF1 mRNA29163160
C004312glycidolglycidol results in decreased expression of LEF1 mRNA15612046
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of LEF1 mRNA17183730
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LEF1 mRNA24796395
D018021Lithium ChlorideLithium Chloride promotes the reaction [LEF1 protein binds to GCG promoter]19582394
D018021Lithium ChlorideLithium Chloride promotes the reaction [LEF1 protein binds to GIP promoter]19582394
D018021Lithium ChlorideLithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GCG promoter]19582394
D018021Lithium ChlorideLithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GIP promoter]19582394
D008148LovastatinLovastatin affects the localization of LEF1 protein17234346
D008713Methimazole[Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of LEF1 protein27421576
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LEF1 gene20938992
D008727Methotrexate[Methotrexate co-treated with Leucovorin] results in increased expression of LEF1 mRNA25187349
C036868methyl carbamatemethyl carbamate results in decreased expression of LEF1 mRNA15612046
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LEF1 mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LEF1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LEF1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of LEF1 mRNA24810058
D009151Mustard GasMustard Gas results in increased expression of LEF1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LEF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LEF1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of LEF1 mRNA19812364
D009532NickelNickel results in increased expression of LEF1 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of LEF1 mRNA22110744
C017557nickel subsulfidenickel subsulfide affects the expression of LEF1 mRNA24952340
C042670N-vinyl-2-pyrrolidinone[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of LEF1 mRNA22037397
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LEF1 mRNA25729387
D010100Oxygen[Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA16272459
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LEF1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of LEF1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of LEF1 mRNA19429403
C006253pirinixic acidpirinixic acid results in increased expression of LEF1 mRNA20813756
D011794QuercetinQuercetin inhibits the reaction [PLAUR protein results in increased expression of LEF1 protein]22511755
C012526quercitrinquercitrin affects the expression of LEF1 mRNA25193878
D015125OxyquinolineOxyquinoline results in decreased expression of LEF1 mRNA15612046
C059514resveratrolresveratrol results in decreased expression of LEF1 mRNA21188121
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA16931933
D012822Silicon DioxideSilicon Dioxide results in increased expression of LEF1 mRNA27095093
D019821SimvastatinSimvastatin results in increased expression of LEF1 mRNA19968183
C017947sodium arsenitesodium arsenite results in decreased expression of LEF1 mRNA27158593
D012999SomanSoman results in increased expression of LEF1 mRNA19281266
D053260SootSoot results in decreased expression of LEF1 mRNA22461453
D010042OuabainOuabain results in decreased expression of LEF1 mRNA28795476
C105686SU 5402SU 5402 results in decreased expression of LEF1 mRNA15255957
D013467SulindacSulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein]11751639
D013629TamoxifenTamoxifen results in increased expression of LEF1 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LEF1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LEF1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEF1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CTNNB1 protein results in increased expression of LEF1 mRNA]24928892
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LEF1 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LEF1 mRNA17586704|1993321
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of LEF1 mRNA21602191
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LEF1 mRNA23519560
D013893ThiramThiram results in increased expression of LEF1 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of LEF1 mRNA27760801
D014050TolueneToluene results in increased expression of LEF1 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LEF1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of LEF1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LEF1 mRNA20530235
C012589trichostatin A[3-deazaneplanocin co-treated with trichostatin A] affects the expression of LEF1 protein18538736
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LEF1 mRNA"27188386
C012589trichostatin Atrichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C012589trichostatin Atrichostatin A inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]22552774
C012589trichostatin Atrichostatin A results in increased expression of LEF1 mRNA24935251|2627250
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of LEF1 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of LEF1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LEF1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of LEF1 mRNA17292431
D024483Vitamin K 3Vitamin K 3 results in decreased expression of LEF1 mRNA25270620
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA23001182  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP23001182  
GO:0003677DNA binding-ISS-  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA11751639  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0005515protein binding-IPI9751710  12192039  17510365  17517646  18077326  18936100  
19460168  20123964  21743491  22261717  23001182  
GO:0008013beta-catenin binding-IBA21873635  
GO:0008013beta-catenin binding-IDA9488439  
GO:0008013beta-catenin binding-IPI10825188  12408825  18936100  20123964  20360943  
GO:0008013beta-catenin binding-TAS16344550  
GO:0008301DNA binding, bending-ISS-  
GO:0030284estrogen receptor activity-IDA18794125  
GO:0030331estrogen receptor binding-IBA21873635  
GO:0030331estrogen receptor binding-IDA18794125  
GO:0035326enhancer binding-IBA21873635  
GO:0035326enhancer binding-IDA7657162  
GO:0042393histone binding-IPI20363964  
GO:0042826histone deacetylase binding-IPI18936100  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IMP20360943  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA9308964  10825188  16344550  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA16344550  17063141  18579517  19351848  20128911  20363964  
GO:0045295gamma-catenin binding-IBA21873635  
GO:0045295gamma-catenin binding-IPI14661054  
GO:0070016armadillo repeat domain binding-IBA21873635  
GO:0070016armadillo repeat domain binding-IPI12408825  
GO:0070742C2H2 zinc finger domain binding-IPI18445004  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001569branching involved in blood vessel morphogenesis-IBA21873635  
GO:0001649osteoblast differentiation-IBA21873635  
GO:0001649osteoblast differentiation-IEP20128911  
GO:0001756somitogenesis-IBA21873635  
GO:0001837epithelial to mesenchymal transition-IBA21873635  
GO:0001837epithelial to mesenchymal transition-ISS-  
GO:0002040sprouting angiogenesis-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IDA23001182  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0008284positive regulation of cell proliferation-IDA19351848  
GO:0010628positive regulation of gene expression-IDA16344550  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP20018240  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0016055Wnt signaling pathway-IDA10644691  
GO:0016202regulation of striated muscle tissue development-IBA21873635  
GO:0021542dentate gyrus development-IBA21873635  
GO:0021861forebrain radial glial cell differentiation-IBA21873635  
GO:0021873forebrain neuroblast division-IBA21873635  
GO:0021943formation of radial glial scaffolds-IBA21873635  
GO:0022407regulation of cell-cell adhesion-IBA21873635  
GO:0030223neutrophil differentiation-IBA21873635  
GO:0030223neutrophil differentiation-IMP17063141  
GO:0030307positive regulation of cell growth-IMP20360943  
GO:0030326embryonic limb morphogenesis-IBA21873635  
GO:0030335positive regulation of cell migration-IMP20018240  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0030854positive regulation of granulocyte differentiation-IDA19620402  
GO:0030854positive regulation of granulocyte differentiation-IMP23001182  
GO:0030879mammary gland development-IBA21873635  
GO:0032696negative regulation of interleukin-13 production-IBA21873635  
GO:0032696negative regulation of interleukin-13 production-IDA18445004  
GO:0032713negative regulation of interleukin-4 production-IBA21873635  
GO:0032713negative regulation of interleukin-4 production-IDA18445004  
GO:0032714negative regulation of interleukin-5 production-IBA21873635  
GO:0032714negative regulation of interleukin-5 production-IDA18445004  
GO:0033153T cell receptor V(D)J recombination-IEA-  
GO:0042100B cell proliferation-IBA21873635  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0043066negative regulation of apoptotic process-IMP20360943  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP20360943  
GO:0043392negative regulation of DNA binding-IDA18445004  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0043586tongue development-IEA-  
GO:0043923positive regulation by host of viral transcription-IDA7657162  
GO:0043966histone H3 acetylation-IMP20363964  
GO:0043967histone H4 acetylation-IMP20363964  
GO:0045063T-helper 1 cell differentiation-ISS-  
GO:0045843negative regulation of striated muscle tissue development-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA18794125  
GO:0045892negative regulation of transcription, DNA-templated-IMP18579517  20363964  
GO:0045893positive regulation of transcription, DNA-templated-IDA7657162  10644691  17063141  19620402  20128911  
GO:0045893positive regulation of transcription, DNA-templated-IMP19351848  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11751639  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP23001182  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046632alpha-beta T cell differentiation-IBA21873635  
GO:0048069eye pigmentation-IBA21873635  
GO:0048341paraxial mesoderm formation-IBA21873635  
GO:0050909sensory perception of taste-IEA-  
GO:0060033anatomical structure regression-IEA-  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA20123964  
GO:0060070canonical Wnt signaling pathway-IMP19576624  
GO:0060325face morphogenesis-IBA21873635  
GO:0060326cell chemotaxis-IDA19576624  
GO:0060561apoptotic process involved in morphogenesis-IBA21873635  
GO:0060710chorio-allantoic fusion-IBA21873635  
GO:0061153trachea gland development-IBA21873635  
GO:0062009secondary palate development-ISS-  
GO:0071345cellular response to cytokine stimulus-IMP23001182  
GO:0071353cellular response to interleukin-4-IDA18579517  
GO:0071864positive regulation of cell proliferation in bone marrow-IBA21873635  
GO:0071864positive regulation of cell proliferation in bone marrow-IMP17063141  
GO:0071866negative regulation of apoptotic process in bone marrow-IBA21873635  
GO:0071866negative regulation of apoptotic process in bone marrow-IMP17063141  
GO:0071895odontoblast differentiation-IBA21873635  
GO:0071899negative regulation of estrogen receptor binding-IDA18794125  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP19402906  
GO:1902262apoptotic process involved in blood vessel morphogenesis-IEA-  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC9308964  
GO:0005634nucleus-IDA17063141  18579517  18936100  23001182  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005667transcription factor complex-IDA11751639  23001182  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA19402906  23001182  
GO:0032993protein-DNA complex-IDA10825188  
GO:1990907beta-catenin-TCF complex-IPI18936100  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma
hsa05221Acute myeloid leukemia
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promotersTAS
R-HSA-4641265Repression of WNT target genesTAS
R-HSA-4641265Repression of WNT target genesIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8951430RUNX3 regulates WNT signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19174556WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. (2009 Feb)Tang YMol Cancer Ther
23210427A whole blood gene expression-based signature for smoking status. (2012 Dec 3)Beineke PBMC Med Genomics
22933707Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin. (2012 Nov)Nagathihalli NSMol Cancer Ther