Gene: HERC5

51191
CEB1|CEBP1
HECT and RLD domain containing E3 ubiquitin protein ligase 5
protein-coding
4q22.1
Ensembl:ENSG00000138646 MIM:608242 Vega:OTTHUMG00000130953 UniprotKB:Q9UII4
NC_000004.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.728e-1 (AD)  6.456e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02215171chr4:89379156HERC51.350e-8Maternal smoking in pregnancy27040690
cg02215171chr4:89379156HERC54.930e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX600.886
DDX60L0.878
PARP140.872
SAMD9L0.861
PARP90.859
PARP120.841
RTP40.841
IFI350.84
SP1100.828
IFIH10.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA1D-0.505
ABCC12-0.499
PIP5KL1-0.469
MYADML2-0.462
MARCH4-0.459
CALHM1-0.457
RHO-0.455
OTUB2-0.451
FADS6-0.45
INPP5J-0.447

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HERC5 mRNA"23146750
C0261142-xylene2-xylene results in increased expression of HERC5 mRNA20359517
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HERC5 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HERC5 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HERC5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HERC5 mRNA22100608
D001280AtrazineAtrazine results in increased expression of HERC5 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of HERC5 mRNA19192274
D001554BenzeneBenzene results in increased expression of HERC5 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HERC5 mRNA19770486
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HERC5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of HERC5 mRNA19619570|2118537
C044887beta-methylcholinebeta-methylcholine affects the expression of HERC5 mRNA21179406
C053541bicalutamidebicalutamide results in increased expression of HERC5 mRNA15638997
C018475butyraldehydebutyraldehyde results in increased expression of HERC5 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of HERC5 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of HERC5 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of HERC5 mRNA26272509
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of HERC5 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of HERC5 mRNA20105288
D016572CyclosporineCyclosporine results in increased expression of HERC5 mRNA20106945|2214713
D016572CyclosporineCyclosporine results in decreased expression of HERC5 mRNA19770486
C014347decitabinedecitabine affects the expression of HERC5 mRNA23300844
D002945CisplatinCisplatin affects the expression of HERC5 mRNA23300844
D002945CisplatinCisplatin affects the reaction [Piroxicam results in increased expression of HERC5 mRNA]21858171
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HERC5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HERC5 mRNA27594783
D004008DiclofenacDiclofenac results in decreased expression of HERC5 mRNA19192274
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HERC5 mRNA21318169
C118739entinostatentinostat results in increased expression of HERC5 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C004912ethylbenzeneethylbenzene results in increased expression of HERC5 mRNA20359517
C069837fullerene C60fullerene C60 analog results in decreased expression of HERC5 mRNA20045429
C069837fullerene C60fullerene C60 analog results in decreased expression of HERC5 protein20045429
C039281furanfuran results in decreased expression of HERC5 mRNA24183702
C010974glyphosateglyphosate results in increased expression of HERC5 mRNA25636363
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of HERC5 mRNA19192274
C000623387HZ-6d compoundHZ-6d compound binds to HERC5 protein28919514
C000623387HZ-6d compoundHZ-6d compound results in decreased expression of HERC5 mRNA28919514
C000623387HZ-6d compoundHZ-6d compound results in decreased expression of HERC5 protein28919514
C492448ICG 001ICG 001 results in increased expression of HERC5 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HERC5 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HERC5 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides affects the expression of HERC5 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of HERC5 mRNA]28070326
C042720mercuric bromidemercuric bromide results in increased expression of HERC5 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
D008752Methylene ChlorideMethylene Chloride results in increased expression of HERC5 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HERC5 mRNA26272509|2800136
D008775MethylprednisoloneMethylprednisolone results in decreased expression of HERC5 mRNA19192274
D009151Mustard GasMustard Gas results in increased expression of HERC5 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HERC5 mRNA"15585362
D009532NickelNickel results in increased expression of HERC5 mRNA24768652
C029938nickel sulfatenickel sulfate results in increased expression of HERC5 mRNA22714537
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of HERC5 mRNA26272509
C046012pentanalpentanal results in increased expression of HERC5 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of HERC5 mRNA23091169
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in increased expression of HERC5 mRNA]21858171
D010894PiroxicamPiroxicam results in increased expression of HERC5 mRNA21858171
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of HERC5 mRNA]28070326
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HERC5 mRNA22714537
D011239PrednisolonePrednisolone results in decreased expression of HERC5 mRNA19192274
D011374ProgesteroneProgesterone results in increased expression of HERC5 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of HERC5 mRNA20864642
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HERC5 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of HERC5 mRNA25351596
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HERC5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HERC5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HERC5 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HERC5 mRNA25613284
D014050TolueneToluene results in increased expression of HERC5 mRNA20359517
D014241TrichloroethyleneTrichloroethylene results in increased expression of HERC5 mRNA20359517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of HERC5 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of HERC5 mRNA24935251|2627250
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of HERC5 mRNA20105288
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HERC5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HERC5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HERC5 mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of HERC5 mRNA22714537
C111237vorinostatvorinostat results in increased expression of HERC5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI20133869  20308324  
GO:0042296ISG15 transferase activity-IBA21873635  
GO:0042296ISG15 transferase activity-IDA20308324  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS10581175  
GO:0000209protein polyubiquitination-TAS-  
GO:0032020ISG15-protein conjugation-IBA21873635  
GO:0032020ISG15-protein conjugation-IDA20308324  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0045087innate immune response-IEA-  
GO:0050688regulation of defense response to virus-IBA21873635  
GO:0050688regulation of defense response to virus-IDA20308324  
GO:0051607defense response to virus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25555412Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. (2015 Sep)Weng JTComput Biol Med