Gene: CKLF

51192
C32|CKLF1|CKLF2|CKLF3|CKLF4|HSPC224|UCK-1
chemokine like factor
protein-coding
16q21
Ensembl:ENSG00000217555 MIM:616074 Vega:OTTHUMG00000137504 UniprotKB:Q9UBR5
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A60.812
PFN10.796
LSM20.795
CYB5A0.794
REXO20.793
RPL230.787
PRDX40.786
DUSP230.775
PSME10.775
IMPDH20.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.545
OR4F29-0.52
SSX5-0.215
GRXCR2-0.208
HES5-0.195
PRAMEF17-0.185
OR10K1-0.184
ARSF-0.183
GRHL2-0.178
SPANXD-0.174

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CKLF mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CKLF mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CKLF mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CKLF mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CKLF mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CKLF mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CKLF mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CKLF mRNA"25510870
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CKLF mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of CKLF mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CKLF mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CKLF mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CKLF gene27153756
C103505AM 251AM 251 results in increased expression of CKLF mRNA16500647
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CKLF mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CKLF mRNA22228805
D004958EstradiolEstradiol affects the expression of CKLF mRNA21826169
D004958EstradiolEstradiol results in decreased expression of CKLF mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of CKLF mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CKLF mRNA21826169
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CKLF mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CKLF mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CKLF mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CKLF mRNA23650126
D002737ChloropreneChloroprene results in decreased expression of CKLF mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CKLF mRNA20938992
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA23503329
C018021cobaltous chloridecobaltous chloride results in decreased expression of CKLF mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of CKLF mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CKLF mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of CKLF mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CKLF mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CKLF mRNA28628672
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA23503329
D002117CalcitriolCalcitriol results in decreased expression of CKLF mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CKLF mRNA21592394
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of CKLF mRNA24834073
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CKLF mRNA15834898
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CKLF mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of CKLF mRNA19167457
D017313FenretinideFenretinide results in increased expression of CKLF mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CKLF mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CKLF mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA23503329
C544151jinfukangjinfukang results in increased expression of CKLF mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CKLF mRNA23086925
C410337K 7174K 7174 results in decreased expression of CKLF mRNA24086573
C008261lead acetatelead acetate affects the expression of CKLF mRNA21829687
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CKLF mRNA20938992
D008942MitoxantroneCKLF protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CKLF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CKLF mRNA"25554681
D009532NickelNickel results in increased expression of CKLF mRNA25583101
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA23503329
C028007nickel monoxidenickel monoxide results in increased expression of CKLF mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CKLF mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of CKLF mRNA18301758|2381119
D011441PropylthiouracilPropylthiouracil results in decreased expression of CKLF mRNA24780913
D011794QuercetinQuercetin results in decreased expression of CKLF mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CKLF mRNA21427059
D012524SarinSarin results in decreased expression of CKLF mRNA19522546
D012524SarinSarin results in increased expression of CKLF mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CKLF mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CKLF mRNA19073995
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CKLF mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CKLF mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CKLF mRNA20844152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CKLF mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CKLF promoter]19654925
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CKLF mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CKLF mRNA21215274
C057693troglitazonetroglitazone results in increased expression of CKLF mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of CKLF mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CKLF mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in increased expression of CKLF mRNA21427059
D014638VanadatesVanadates results in increased expression of CKLF mRNA22714537
D014640VancomycinVancomycin results in decreased expression of CKLF mRNA18930951
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA23503329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008009chemokine activity-IDA11415443  
GO ID GO Term Qualifier Evidence PubMed
GO:0008283cell proliferation-IDA11415443  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IDA11415443  
GO:0032940secretion by cell-IDA11415443  
GO:0048246macrophage chemotaxis-IDA11415443  
GO:0048247lymphocyte chemotaxis-IDA11415443  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA11415443  
GO:0005615extracellular space-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IDA11415443  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27521994Elevated methylation of CMTM3 promoter in the male laryngeal squamous cell carcinoma patients. (2016 Nov)Shen ZClin Biochem