Gene: IPO11

51194
RanBP11
importin 11
protein-coding
5q12.1
Ensembl:ENSG00000086200 MIM:610889 Vega:OTTHUMG00000154400 UniprotKB:Q9UI26
NC_000005.10
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.438e-1 (AD)  8.080e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RANBP20.905
SEL1L0.902
MAPK140.9
YTHDF30.899
BFAR0.892
EXOC20.891
EPRS0.888
TM9SF20.888
TRAPPC80.887
MTDH0.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.529
OR4F29-0.486
KLRB1-0.27
CSAG1-0.267
SOX3-0.261
C6orf10-0.257
S100A1-0.256
MTRNR2L6-0.24
PON1-0.239
KLRK1-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IPO11 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of IPO11 mRNA"20702594
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of IPO11 mRNA14583596
D000082AcetaminophenAcetaminophen results in decreased expression of IPO11 mRNA21420995|2669055
D000082AcetaminophenAcetaminophen affects the expression of IPO11 mRNA17562736
D001280AtrazineAtrazine results in decreased expression of IPO11 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IPO11 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in increased expression of IPO11 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of IPO11 mRNA19320972
D003375CoumestrolCoumestrol results in increased expression of IPO11 mRNA19167446
D004041Dietary FatsDietary Fats results in increased expression of IPO11 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of IPO11 mRNA]19030233
D002117CalcitriolCalcitriol results in decreased expression of IPO11 mRNA16847355
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IPO11 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IPO11 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IPO11 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IPO11 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of IPO11 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IPO11 mRNA25613284
D008345ManganeseManganese results in decreased expression of IPO11 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of IPO11 mRNA17175027
D008727MethotrexateMethotrexate results in decreased expression of IPO11 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IPO11 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IPO11 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of IPO11 promoter"26251327
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IPO11 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of IPO11 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IPO11 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IPO11 mRNA22079256
C089032rimonabantrimonabant affects the expression of IPO11 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of IPO11 mRNA]19030233
C017947sodium arsenitesodium arsenite results in decreased expression of IPO11 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IPO11 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IPO11 mRNA20702594|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IPO11 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IPO11 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of IPO11 mRNA23409001
C012589trichostatin Atrichostatin A results in decreased expression of IPO11 mRNA24935251
D014520UrethaneUrethane results in decreased expression of IPO11 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of IPO11 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased methylation of IPO11 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IPO11 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008536Ran GTPase binding-IEA-  
GO:0008565protein transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006606protein import into nucleus-IBA21873635  
GO:0006610ribosomal protein import into nucleus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA-  
GO:0005635nuclear envelope-IBA21873635  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23216389Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. (2013 May)Zuo LAlcohol Clin Exp Res
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res