Gene: PLCE1

51196
NPHS3|PLCE|PPLC
phospholipase C epsilon 1
protein-coding
10q23.33
Ensembl:ENSG00000138193 MIM:608414 Vega:OTTHUMG00000018789 UniprotKB:Q9P212
NG_015799.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.542e-2 (AD)  9.506e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMC10.8
ATP10D0.77
LPP0.758
CFLAR0.754
CALD10.75
TEP10.749
JAG10.736
FLNA0.732
FAM111A0.726
FSTL10.725

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPEF1-0.341
GSG1-0.333
HAS1-0.331
OR4F5-0.327
CRH-0.32
C1orf53-0.312
SLC7A4-0.312
C2CD4D-0.31
DLK2-0.305
OR4F29-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolPLCE1 protein results in increased susceptibility to 1-UFT protocol16734730
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLCE1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PLCE1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PLCE1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PLCE1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLCE1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLCE1 mRNA19770486
C096920AGN 193109AGN 193109 inhibits the reaction [Tretinoin results in increased expression of PLCE1 mRNA]16505366
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PLCE1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLCE1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of PLCE1 mRNA24449571
D001151ArsenicArsenic affects the methylation of PLCE1 gene25304211
D001194AsbestosAsbestos results in decreased expression of PLCE1 mRNA22398240
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PLCE1 mRNA"17331233
C487081belinostatbelinostat results in decreased expression of PLCE1 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLCE1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLCE1 mRNA22610609
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PLCE1 mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of PLCE1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of PLCE1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PLCE1 mRNA15336504
D000069287CapecitabinePLCE1 protein results in increased susceptibility to Capecitabine16734730
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCE1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLCE1 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of PLCE1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of PLCE1 mRNA19770486
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PLCE1 mRNA26924002
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PLCE1 mRNA24535843
C025034doxifluridinePLCE1 protein results in increased susceptibility to doxifluridine16734730
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of PLCE1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLCE1 mRNA22079256
D000431EthanolEthanol results in decreased expression of PLCE1 mRNA20655511
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to PLCE1 protein27129696
D005485FlutamideFlutamide results in decreased expression of PLCE1 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCE1 mRNA20938992
D005839GentamicinsGentamicins results in decreased expression of PLCE1 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of PLCE1 mRNA28973697
C008261lead acetatelead acetate results in increased expression of PLCE1 mRNA20542052
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA22563483
D008345ManganeseManganese results in increased expression of PLCE1 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of PLCE1 mRNA17175027
C042720mercuric bromidemercuric bromide results in increased expression of PLCE1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
D008701MethapyrileneMethapyrilene results in decreased methylation of PLCE1 gene26431795
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCE1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PLCE1 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PLCE1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLCE1 mRNA"25620056
D009532NickelNickel results in decreased expression of PLCE1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of PLCE1 mRNA22714537
D017239PaclitaxelPLCE1 protein results in decreased susceptibility to Paclitaxel16734730
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLCE1 mRNA26272509
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA22563483
D010269ParaquatParaquat results in increased expression of PLCE1 mRNA22563483
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PLCE1 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of PLCE1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PLCE1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLCE1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PLCE1 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLCE1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PLCE1 mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PLCE1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PLCE1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of PLCE1 mRNA19690047
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PLCE1 mRNA27029645
C428725pyridabenpyridaben results in increased expression of PLCE1 mRNA22563483
C012526quercitrinquercitrin affects the expression of PLCE1 mRNA25193878
C017947sodium arsenitesodium arsenite affects the methylation of PLCE1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of PLCE1 mRNA24570342
C017947sodium arsenitesodium arsenite results in decreased methylation of PLCE1 gene24570342
D053260SootSoot results in decreased expression of PLCE1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLCE1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLCE1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLCE1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLCE1 mRNA26232522
C009495titanium dioxidetitanium dioxide results in increased expression of PLCE1 mRNA23409001
D014212TretinoinTretinoin results in increased expression of PLCE1 mRNA21934132
D014212TretinoinAGN 193109 inhibits the reaction [Tretinoin results in increased expression of PLCE1 mRNA]16505366
D014212TretinoinTretinoin results in increased expression of PLCE1 mRNA16505366
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PLCE1 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PLCE1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLCE1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PLCE1 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of PLCE1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PLCE1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of PLCE1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of PLCE1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-IDA11022047  11022048  
GO:0004435phosphatidylinositol phospholipase C activity-TAS-  
GO:0004629phospholipase C activity-IDA11022047  
GO:0005085guanyl-nucleotide exchange factor activity-TAS11022047  
GO:0005515protein binding-IPI11022048  
GO:0017016Ras GTPase binding-IDA11022048  
GO:0019899enzyme binding-IPI11022048  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA11022047  
GO:0001558regulation of cell growth-TAS11022047  
GO:0006651diacylglycerol biosynthetic process-TAS11022047  
GO:0006940regulation of smooth muscle contraction-TAS11022047  
GO:0007010cytoskeleton organization-NAS11022047  
GO:0007173epidermal growth factor receptor signaling pathway-NAS11022048  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IDA11022047  11022048  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS11022047  
GO:0007265Ras protein signal transduction-IDA11022048  
GO:0007507heart development-TAS11022047  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IDA11022047  
GO:0008283cell proliferation-NAS11022048  
GO:0016042lipid catabolic process-IEA-  
GO:0019722calcium-mediated signaling-NAS11022048  
GO:0019722calcium-mediated signaling-TAS11022047  
GO:0032835glomerulus development-IMP17086182  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0045859regulation of protein kinase activity-IDA11022047  
GO:0046578regulation of Ras protein signal transduction-IDA11022047  
GO:0048016inositol phosphate-mediated signaling-TAS11022047  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005829cytosol-IDA11022048  
GO:0005886plasma membrane-IDA11022048  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24935391Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley. (2014)Malik MAAsian Pac J Cancer Prev
28007352Esophageal cancer in high-risk areas of China: research progress and challenges. (2017 Mar)Lin YAnn Epidemiol
25434319Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley. (2014 Nov-Dec)Malik MASaudi J Gastroenterol
25008389HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC). (2014 Jul 9)Yang JBMC Cancer
29387411Phospholipase C epsilon-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China. (2018 Jan)Zhou RMMol Clin Oncol
25854357PLCE1 gene in esophageal cancer and interaction with environmental factors. (2015)Guo LYAsian Pac J Cancer Prev