Gene: NIN

51199
SCKL7
ninein
protein-coding
14q22.1
Ensembl:ENSG00000100503 MIM:608684 Vega:OTTHUMG00000029569 UniprotKB:Q8N4C6
NG_032968.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.346e-1 (AD)  9.569e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20969923chr14:51295867NINPromoter1.440e-4Alcohol use disorders26763658
cg03048432chr14:51290751NIN1.250e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM260.905
CCNT20.905
CDK130.903
SMG10.902
AP1G10.898
OGT0.896
ZFC3H10.895
U2SURP0.895
RPS6KB10.894
ARGLU10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.59
OR4F29-0.552
KLRC2-0.266
CD8B-0.258
S100A1-0.235
PAGE4-0.229
NKX6-1-0.227
AVP-0.226
OR4F16-0.225
SOX14-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NIN mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NIN mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of NIN mRNA22230336|2559613
D000082AcetaminophenAcetaminophen affects the expression of NIN mRNA17562736
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA]16949557
C025154alpha-cobratoxinalpha-cobratoxin results in decreased expression of NIN mRNA16949557
D001280AtrazineAtrazine results in decreased expression of NIN mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NIN mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NIN mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NIN mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NIN mRNA"19150397
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NIN mRNA28628672
C006780bisphenol Abisphenol A affects the expression of NIN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NIN gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NIN mRNA25596134
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NIN mRNA17484886
D002330CarmustineNIN mRNA affects the susceptibility to Carmustine16365179
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of NIN mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NIN mRNA16934159
C059262cidofovircidofovir results in decreased expression of NIN mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of NIN mRNA25596134
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of NIN mRNA20971185
D003471CuprizoneCuprizone results in increased expression of NIN mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of NIN mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of NIN mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NIN mRNA28628672
D002945CisplatinCisplatin results in decreased expression of NIN mRNA25596134
D004041Dietary FatsDietary Fats results in increased expression of NIN mRNA18042831
D004237DiuronDiuron results in increased expression of NIN mRNA25152437
C118739entinostatentinostat results in decreased expression of NIN mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
D000431EthanolNIN protein affects the susceptibility to Ethanol26948279
D017313FenretinideFenretinide results in increased expression of NIN mRNA28973697
D007069IfosfamideIfosfamide results in decreased expression of NIN mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NIN mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NIN mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NIN mRNA28628672
D007854LeadLead affects the expression of NIN mRNA28903495
C008261lead acetatelead acetate results in decreased expression of NIN mRNA21829687
D008687MetforminMetformin results in increased expression of NIN mRNA25596134
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NIN mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NIN mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NIN mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of NIN promoter"26251327
C502362N-butyrylglucosamineN-butyrylglucosamine results in decreased expression of NIN mRNA16142878
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA]16949557
D009538NicotineNicotine results in increased expression of NIN mRNA16949557
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]16949557
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of NIN mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NIN mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of NIN mRNA25596134
D000073878Palm OilPalm Oil results in increased expression of NIN mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NIN mRNA27153767
D010936Plant ExtractsPlant Extracts results in increased expression of NIN mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of NIN mRNA19690047
D011794QuercetinQuercetin results in decreased expression of NIN protein15221776
D012402RotenoneRotenone results in increased expression of NIN mRNA19013527
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of NIN mRNA"21148743
D012999SomanSoman results in increased expression of NIN mRNA19281266
C047246temozolomideNIN mRNA affects the susceptibility to temozolomide16365179
D013739TestosteroneTestosterone results in decreased expression of NIN mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NIN mRNA22903824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NIN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NIN mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NIN mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NIN mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NIN mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NIN mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NIN mRNA25729387
C032910triadimefontriadimefon results in decreased expression of NIN mRNA26790661
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NIN mRNA26272509
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]16949557
D014403TubocurarineTubocurarine results in decreased expression of NIN mRNA16949557
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NIN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NIN mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of NIN gene29154799
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NIN mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of NIN mRNA26272509
D019287Zinc SulfateZinc Sulfate results in increased expression of NIN mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI11004522  12927815  15147888  16154161  17139249  20596670  
28422092  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0008104protein localization-IMP23213374  
GO:0010457centriole-centriole cohesion-IMP23213374  
GO:0034454microtubule anchoring at centrosome-IBA21873635  
GO:0034454microtubule anchoring at centrosome-IMP23386061  
GO:0051642centrosome localization-IBA21873635  
GO:0051642centrosome localization-TAS16154161  
GO:0090222centrosome-templated microtubule nucleation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000242pericentriolar material-IBA21873635  
GO:0000242pericentriolar material-IDA8834802  
GO:0000922spindle pole-IMP18331714  
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005813centrosome-IDA12927815  15147888  21399614  
GO:0005814centriole-IBA21873635  
GO:0005814centriole-IDA23213374  23386061  
GO:0036449microtubule minus-end-IBA21873635  
GO:0072686mitotic spindle-IDA15147888  
GO:0097431mitotic spindle pole-IBA21873635  
GO:0097539ciliary transition fiber-IBA21873635  
GO:0120103centriolar subdistal appendage-IDA23213374  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20056645Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome. (2010 Jan)Couch FJCancer Epidemiol Biomarkers Prev
23459936Exploring the genetic basis of chronic periodontitis: a genome-wide association study. (2013 Jun 1)Divaris KHum Mol Genet
23908141Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk. (2013 Nov)Jang JHMol Carcinog