Gene: CPA4

51200
CPA3
carboxypeptidase A4
protein-coding
7q32.2
Ensembl:ENSG00000128510 MIM:607635 Vega:OTTHUMG00000157825 UniprotKB:Q9UI42
NG_011788.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.346e-1 (AD)  8.468e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BYSL0.549
FOXP20.535
STMND10.535
SMIM120.534
STARD130.519
C11orf240.516
PROK10.513
NANS0.511
MPP30.51
TLE40.51

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
P2RY14-0.364
TFAP2C-0.329
DIO3-0.326
DIO2-0.322
EYA1-0.319
DIAPH3-0.308
FOXL1-0.307
HIGD1B-0.305
TNS3-0.304
ANGPTL1-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CPA4 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of CPA4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CPA4 mRNA22100608
D000393Air PollutantsAir Pollutants analog results in increased expression of CPA4 mRNA21757418
D000447AldehydesAldehydes results in increased expression of CPA4 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CPA4 mRNA21298039
C519728archazolid Barchazolid B results in increased expression of CPA4 mRNA25218289
C015001arsenitearsenite results in decreased expression of CPA4 mRNA23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPA4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPA4 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CPA4 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of CPA4 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CPA4 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of CPA4 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CPA4 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased secretion of CPA4 protein22079246
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CPA4 mRNA20971185
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of CPA4 protein19822598
D016572CyclosporineCyclosporine results in decreased expression of CPA4 mRNA27989131
D000069439DasatinibDasatinib results in decreased expression of CPA4 mRNA20579391
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CPA4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CPA4 mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of CPA4 mRNA16002434
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CPA4 mRNA25187966
D005472FluorouracilFluorouracil results in decreased expression of CPA4 mRNA16510598
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CPA4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CPA4 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CPA4 mRNA26752646
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CPA4 mRNA26378955
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CPA4 mRNA26011545
C059539midostaurinmidostaurin results in increased expression of CPA4 mRNA20980353
D009151Mustard GasMustard Gas results in increased expression of CPA4 mRNA25102026
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CPA4 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of CPA4 mRNA20971185
C500026palbociclibpalbociclib results in increased expression of CPA4 mRNA22869556
C046012pentanalpentanal results in increased expression of CPA4 mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of CPA4 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CPA4 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CPA4 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of CPA4 mRNA23922661
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CPA4 mRNA26378955
D014212TretinoinTretinoin results in decreased expression of CPA4 mRNA23830798
D014415TunicamycinTunicamycin results in increased expression of CPA4 mRNA17127020
D014635Valproic AcidValproic Acid results in increased expression of CPA4 mRNA28001369
D014638VanadatesVanadates results in increased expression of CPA4 mRNA22714537
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of CPA4 mRNA"22326570
C088658zoledronic acidzoledronic acid results in decreased expression of CPA4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004181metallocarboxypeptidase activity-IBA21873635  
GO:0004181metallocarboxypeptidase activity-NAS10383164  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0016573histone acetylation-NAS10383164  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal