Gene: ACP6

51205
ACPL1|LPAP|PACPL1
acid phosphatase 6, lysophosphatidic
protein-coding
1q21.2
Ensembl:ENSG00000162836 MIM:611471 Vega:OTTHUMG00000014019 UniprotKB:Q9NPH0
NG_050757.1
SNP Mapped
1   ANCO-SNPs
AD
0   
2.646e-1 (AD)  8.093e-1 (ND)   (Frontal_Cortex)
3.274e-1 (AD)  5.509e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13374159chr1:147670335 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGD40.645
TRPS10.639
ARSD0.638
ZNRF30.637
CAPN20.631
TPP10.629
PCTP0.628
DOCK70.628
LRIG10.624
RYR30.623

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.31
CRH-0.306
SERF1B-0.298
LBH-0.286
DUSP4-0.281
OR4F29-0.274
BARX2-0.264
DUSP27-0.264
SST-0.256
PNOC-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ACP6 mRNA"25614096
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACP6 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of ACP6 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of ACP6 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of ACP6 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ACP6 mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of ACP6 mRNA25064622
C547126AZM551248AZM551248 results in decreased expression of ACP6 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACP6 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of ACP6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ACP6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of ACP6 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of ACP6 gene28505145
D002746ChlorpromazineChlorpromazine affects the expression of ACP6 mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of ACP6 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ACP6 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of ACP6 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of ACP6 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ACP6 mRNA27392435
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of ACP6 mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ACP6 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ACP6 mRNA23550701
D005485FlutamideFlutamide results in decreased expression of ACP6 mRNA24793618
D005485FlutamideFlutamide results in increased expression of ACP6 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of ACP6 mRNA19167457
D007213IndomethacinIndomethacin results in increased expression of ACP6 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACP6 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ACP6 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ACP6 mRNA27392435
D007649KetamineKetamine results in decreased expression of ACP6 mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ACP6 mRNA"24972896
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in increased expression of ACP6 mRNA26667767
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ACP6 mRNA26011545
D009532NickelNickel results in decreased expression of ACP6 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of ACP6 mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ACP6 protein19716841
D010269ParaquatParaquat affects the expression of ACP6 mRNA25064622
D011374ProgesteroneProgesterone results in increased expression of ACP6 mRNA23012394|2301818
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in increased expression of ACP6 mRNA26667767
D015474IsotretinoinIsotretinoin results in decreased expression of ACP6 mRNA20436886
C541923sandostatinLARsandostatinLAR results in decreased expression of ACP6 mRNA17210224
C009277sodium arsenatesodium arsenate results in increased expression of ACP6 mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of ACP6 gene28589171
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of ACP6 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACP6 mRNA26377647
D013752TetracyclineTetracycline affects the expression of ACP6 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACP6 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ACP6 mRNA25064622
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ACP6 gene27618143
D014635Valproic AcidValproic Acid affects the expression of ACP6 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of ACP6 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ACP6 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of ACP6 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003993acid phosphatase activity-IEA-  
GO:0052642lysophosphatidic acid phosphatase activity-IDA10506173  23807634  
GO:0052642lysophosphatidic acid phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-IMP10506173  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0016311dephosphorylation-IEA-  
GO:2001311lysobisphosphatidic acid metabolic process-IDA23807634  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA12010880  
GO:0005739mitochondrion-IDA10506173  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00740Riboflavin metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal